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Full-Text Articles in Medicine and Health Sciences
Rural Breast Cancer Patients And Survivors Perspectives Using Online Health Resources, Julie W. Merten, Kim Walsh-Childers, Lakeisha Rodman, Mary Ellen Young, Natalie Birchwood
Rural Breast Cancer Patients And Survivors Perspectives Using Online Health Resources, Julie W. Merten, Kim Walsh-Childers, Lakeisha Rodman, Mary Ellen Young, Natalie Birchwood
Julie Merten
Background: Breast cancer is the second most common cancer in women, with over 2.5 million breast cancer survivors in the United States. These patients, survivors and their loved ones use the Internet to find information about breast cancer, search for treatment options and connect with support groups. For women in medically underserved areas, especially rural areas, the Internet could be one of their only sources of information.
Objective: The study investigates rural breast cancer patients’ and survivors’ motivations to seek online information, ability to use the Internet as a health information source, barriers to finding the information they …
Integrated Bioinformatics, Environmental Epidemiologic And Genomic Approaches To Identify Environmental And Molecular Links Between Endometriosis And Breast Cancer, Deodutta Roy, Marisa L. Morgan, Changwon Yoo, Alok Deoraj, Sandhya Roy, Vijay Kumar Yadav, Mohannad Garoub, Hamza Assaggaf, Mayur Doke
Integrated Bioinformatics, Environmental Epidemiologic And Genomic Approaches To Identify Environmental And Molecular Links Between Endometriosis And Breast Cancer, Deodutta Roy, Marisa L. Morgan, Changwon Yoo, Alok Deoraj, Sandhya Roy, Vijay Kumar Yadav, Mohannad Garoub, Hamza Assaggaf, Mayur Doke
Alok Deoraj
We present a combined environmental epidemiologic, genomic, and bioinformatics approach to identify: exposure of environmental chemicals with estrogenic activity; epidemiologic association between endocrine disrupting chemical (EDC) and health effects, such as, breast cancer or endometriosis; and gene-EDC interactions and disease associations. Human exposure measurement and modeling confirmed estrogenic activity of three selected class of environmental chemicals, polychlorinated biphenyls (PCBs), bisphenols (BPs), and phthalates. Meta-analysis showed that PCBs exposure, not Bisphenol A (BPA) and phthalates, increased the summary odds ratio for breast cancer and endometriosis. Bioinformatics analysis of gene-EDC interactions and disease associations identified several hundred genes that were altered by …