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Full-Text Articles in Medicine and Health Sciences
Evidence- Based Homoeopathy: Case Report Of Alopecia Areata In An 11 Year Old Boy, Ashish Shivadikar
Evidence- Based Homoeopathy: Case Report Of Alopecia Areata In An 11 Year Old Boy, Ashish Shivadikar
Indian Journal of Research in Homoeopathy
Introduction: Alopecia areata (AA) is an autoimmune disease characterised by non-scarring hair loss in single or multiple areas of the scalp. The disease affects hair on the head or other parts of the body. AA occurs in people of all ages and affects 1-2% of human population. Homoeopathic literature shows that cases of AA have been treated successfully with homoeopathic medicines. Case Summary: This is the case of an 11 years old boy with alopecia areata. The case presented here is documented from Dermatology clinic at Regional Research Institute of Homoeopathy at Gudivada, Andhra Pradesh. The patient was treated with …
Effects Of Epac1 On Diabetic Retinal Inflammation, Claire Hawthorne, Jena Steinle, Phd, Youde Jiang, Ms, Li Liu, Phd
Effects Of Epac1 On Diabetic Retinal Inflammation, Claire Hawthorne, Jena Steinle, Phd, Youde Jiang, Ms, Li Liu, Phd
Journal of Health Disparities Research and Practice
An ever-growing body of research suggests that inflammation is one of the primary causes of diabetic retinopathy, as the inflammation can lead to insulin resistance. Beta-adrenergic receptor agonists can reduce the inflammation in human retinal endothelial cells (HRECs), but are not a viable treatment due to systemic effects. Epac1 lies downstream of beta-adrenergic receptor signaling, and it may have the capability to reduce inflammation by acting as an alternative pathway for beta-adrenergic receptor agonists to block inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1B). We hypothesized that the Epac1 agonist will decrease cytokine levels, leading to …
Mean Platelet Volume As A Diagnostic Marker In Children With Acute Hepatitis A, Amany F. Ismael, Maha A. Tawfik, Soheir S. Abou El-Ella
Mean Platelet Volume As A Diagnostic Marker In Children With Acute Hepatitis A, Amany F. Ismael, Maha A. Tawfik, Soheir S. Abou El-Ella
Menoufia Medical Journal
Objective The aim of this study was to assess the level of mean platelet volume (MPV) in children with acute hepatitis A as compared with the control group. Background MPV is a marker that indicates platelet size, function, and the rate of platelet production and activation. Patients and methods Our study was conducted on 100 Egyptian children, aged from 2 to 14 years (58 male and 42 female) previously diagnosed as having hepatitis A as a patient group and 100 apparently healthy age-matched and sex-matched children as a control group. All of them were subjected to full history, physical examination, …
Attenuation Of Complete Freund's Adjuvant-Induced Arthritis By Different Dilutions Of Eupatorium Perfoliatum And Crotalus Horridus And Their Safety Evaluation, Surender Singh, Karwasra Ritu, Prerna Kalra, Debadatta Nayak, Anil Khurana, Raj Manchanda
Attenuation Of Complete Freund's Adjuvant-Induced Arthritis By Different Dilutions Of Eupatorium Perfoliatum And Crotalus Horridus And Their Safety Evaluation, Surender Singh, Karwasra Ritu, Prerna Kalra, Debadatta Nayak, Anil Khurana, Raj Manchanda
Indian Journal of Research in Homoeopathy
Objective: The aim of this study was to investigate, the inhibitory effect of the homoeopathic drugs – Eupatorium perfoliatum and Crotalus horridus in experimental models of inflammation and Complete Freund's Adjuvant (CFA)-induced arthritis with evaluation of their safety aspects by acute and subacute toxicity studies. Materials and Methods: Animals were divided into eight groups (n = 6). Eupatorium perfoliatum and Crotalus horridus in different dilutions (6CH, 12CH, 30CH and 200CH) were administered orally, daily during the study period of 21 days, and their effect on joint dysfunction was evaluated by measuring joint diameter in CFA-induced arthritis model. In addition, inflammatory …
Study Of Serum Ykl-40 Level In Patients With Chronic Obstructive Pulmonary Disease, Ahmed A. Khames, Doaa S. Fouda, Ibrahim S. El Madbouh, Maha Yousif, Nourane Y. Azab
Study Of Serum Ykl-40 Level In Patients With Chronic Obstructive Pulmonary Disease, Ahmed A. Khames, Doaa S. Fouda, Ibrahim S. El Madbouh, Maha Yousif, Nourane Y. Azab
Menoufia Medical Journal
Objective The aim of the paper was to investigate the relationship between serum YKL-40 levels and severity of chronic obstructive pulmonary disease (COPD). Background COPD is a major health problem with increasing morbidity and mortality throughout the world. A newly recognized biomarker, YKL-40, is a chitin-binding glycoprotein, and its serum level is elevated in inflammatory diseases. However, it has not been thoroughly investigated in COPD. Patients and methods A total of 30 patients with stable COPD and 10 healthy individuals as a control group were enrolled for estimation of modified Medical Research Counseling dyspnea scale, spirometry, and serum YKL-40 levels. …
Impact Of Time Restricted Feeding On Markers Of Cardiometabolic Health, Liliana I. Renteria, Elias Villalobos, Hunter S. Waldman, Matthew J. Mcallister
Impact Of Time Restricted Feeding On Markers Of Cardiometabolic Health, Liliana I. Renteria, Elias Villalobos, Hunter S. Waldman, Matthew J. Mcallister
International Journal of Exercise Science: Conference Proceedings
Time restricted feeding (TRF) is a form of intermittent fasting in which all calories are consumed within a certain amount of time (i.e. 6-8 hrs) only water is ingested for the remainder of the day. Previous research shows improvements in body composition and some markers of cardiometabolic health, but it is not clear if these results were due to the decreased eating window, or due to a decrease in caloric intake that typically occurs with fasting protocols. PURPOSE: to assess whether a caloric deficit is necessary to achieve improvements in cardiometabolic health as well as evaluate the impact TRF has …
Curcumin And Boswellia Serrata Supplementation Result In Reduced Inflammation Following Eccentric Leg Press Exercise, Asheal A. Davis, Elizabeth A. Tanner, Melody A. Gary, Brian K. Mcfarlin
Curcumin And Boswellia Serrata Supplementation Result In Reduced Inflammation Following Eccentric Leg Press Exercise, Asheal A. Davis, Elizabeth A. Tanner, Melody A. Gary, Brian K. Mcfarlin
International Journal of Exercise Science: Conference Proceedings
Repetitive exercise on consecutive days is a key component of many long-term training plans. This type of exercise results in muscle inflammation and soreness that limits the capacity to sustain exercise at a high effort. Several dietary polyphenols have the capacity to manage inflammation and thus supplementation may be an effective component of a long-term training plan. PURPOSE:The purpose of this study was to investigate the effect of combined oral supplementation with curcumin and boswellia serrata prior to and following three consecutive days of intense interval exercise. METHODS:All protocols were approved by the University IRB committee and participants …
Inflammation-Associated Rna Signaling Is Reduced Following A Half-Marathon Race When Supplemented With Curcumin And A Pomegranate Extract, Elizabeth A. Tanner, Melody A. Gary, Asheal A. Davis, Brian K. Mcfarlin
Inflammation-Associated Rna Signaling Is Reduced Following A Half-Marathon Race When Supplemented With Curcumin And A Pomegranate Extract, Elizabeth A. Tanner, Melody A. Gary, Asheal A. Davis, Brian K. Mcfarlin
International Journal of Exercise Science: Conference Proceedings
Prolonged endurance exercise performances provide a unique model for investigating the combined effects of oxidative stress and eccentric muscle contraction on differential gene expression with nutritional interventions known to blunt inflammation. Dietary polyphenols (i.e. curcumin, pomegranate, etc.) have been shown to reduce exercise-induced inflammation associated mRNA and protein expression with fewer side effects than NSAIDs. PURPOSE: To investigate the effect of combined curcumin (500-1000 mg/d; Longvida®) and pomegranate extract (500-1000 mg/d; Pomella®) supplement for 30-days on mRNA expression following a half marathon race. METHODS: All protocols were approved by the University IRB committee and participants gave written informed consent. Participants …
Using Dietary Polyphenols To Manage Post Exercise Inflammation, Melody A. Gary, Elizabeth A. Tanner, Brian K. Mcfarlin, Asheal A. Davis
Using Dietary Polyphenols To Manage Post Exercise Inflammation, Melody A. Gary, Elizabeth A. Tanner, Brian K. Mcfarlin, Asheal A. Davis
International Journal of Exercise Science: Conference Proceedings
Individuals participating in prolonged exercise sessions and associated training experience regular inflammation and muscle soreness. Natural products with known anti-inflammatory and/or oxidative stress blocking effects represent attractive options to traditional NSAID treatments. PURPOSE: To investigate the effect of combined curcumin (500-1000 mg/d; Longvida®), pomegranate extract (500-1000 mg/d; Pomella®), and Methylsulfonylmethane (500-1000 mg/d; OptiMSM®) supplement for 30-days on protein inflammatory biomarkers, inflammation-associated RNA, and oxidative. METHODS: All protocols were approved by the University IRB committee and participants gave written informed consent. Subjects were supplemented for 30-d prior to the half marathon race. Venous blood samples were collected for serum or RNA …
Circulating Inflammatory And Oxidative Stress Responses To Steady-State Moderate-Intensity And High-Intensity Interval Exercise In Mid-Spectrum Chronic Kidney Disease, Matthew Peterson, Jeffrey S. Forsse, James K. Taylor, Zach Papadakis, Nick Schwedock, Burritt Hess, Jackson O. Griggs Md, Crawford Allison, Ron Wilson Md, Kathleen Adair, Mitch Cholewinski, Peter Grandjean
Circulating Inflammatory And Oxidative Stress Responses To Steady-State Moderate-Intensity And High-Intensity Interval Exercise In Mid-Spectrum Chronic Kidney Disease, Matthew Peterson, Jeffrey S. Forsse, James K. Taylor, Zach Papadakis, Nick Schwedock, Burritt Hess, Jackson O. Griggs Md, Crawford Allison, Ron Wilson Md, Kathleen Adair, Mitch Cholewinski, Peter Grandjean
International Journal of Exercise Science: Conference Proceedings
Inflammation and oxidative stress can be potent modulators of vascular function. These factors may transiently respond to moderate-intensity steady state exercise (SSE) in a manner that improves post-exercise vascular function in healthy adults. Whether exercise imparts similar effects in adults with Stage 3 or 4 chronic kidney disease (CKD) remains understudied. Moreover, a comparison of SSE and high-intensity interval exercise (HIIE) may add to clinically-relevant findings for improving vascular function in mid-spectrum CKD. PURPOSE: To determine the influence of SSE and a comparable amount of HIIE on post-exercise inflammation and oxidative stress in patients diagnosed with secondary Stage 3 or …
Hemophagocytic Lymphohistiocytosis: Epidemiological, Clinical And Biological Profile, Hanane Zahir, Jihane Belkhir, Hanane Mouhib, Mustapha Ait Ameur, Mohammed Chakour
Hemophagocytic Lymphohistiocytosis: Epidemiological, Clinical And Biological Profile, Hanane Zahir, Jihane Belkhir, Hanane Mouhib, Mustapha Ait Ameur, Mohammed Chakour
Turkish Journal of Medical Sciences
Background/aim: Hemophagocytic lymphohistiocytosis (HLH) is a clinical, biological, and pathological entity that is rare but has certain morbidity that may be life-threatening. This work aims to establish a focus on the hemophagocytic lymphohistiocytosis and analyze different aspects of diagnosis while emphasizing the biological data.Materials and methods: We report the results of a retrospective study conducted in the hematology department of Avicenna Hospital in Marrakesh. Thirty-one patients with hemophagocytic lymphohistiocytosis were enrolled.Results: The clinical presentation was dominated by fever and deterioration of the general state for almost all our patients. Splenomegaly was objectified in 90% of the patients. Hepatomegaly, lymphadenopathy, and …
Irak-4 Rs4251481 Gene Variant: As A Risk Factor On Inflammatory Bowel Disease, Gonca Candan, Resul Kahraman, Hayri̇ye Arzu Ergen
Irak-4 Rs4251481 Gene Variant: As A Risk Factor On Inflammatory Bowel Disease, Gonca Candan, Resul Kahraman, Hayri̇ye Arzu Ergen
Turkish Journal of Medical Sciences
Background/aim: Abnormal immune response occurs in individuals who have alleles associated with innate and adaptive immune mechanisms that predispose to inflammatory bowel disease (IBD). Interleukin-1 receptor-associated kinase 4 (IRAK-4) involved in the pathway produces cytokines that initiate and maintain inflammation through Toll-like receptors and interleukin-1 receptors on the membranes of innate immune cells are stimulated with antigens. It was aimed to investigate whether IRAK-4 rs3794262 and rs4251481 polymorphisms predispose to IBD and the possible effects of these polymorphisms by examining these gene polymorphisms with the clinic and prognostic parameters of IBD.Material and methods: Real-time PCR technique was used to detect …
Serum Fetuin-A Is Associated With The Components Of Miac(Malnutrition, Inflammation, Atherosclerosis, Calcification) Syndrome In Different Stages, Rüya Mutluay, Ceyla Konca Değerteki̇n, Emel Işiktaş Sayilar, Ülver Deri̇ci̇, Serap Gülteki̇n, Sevi̇m Gönen, Seli̇m Turgay Arinsoy, Mahmut Şükrü Si̇ndel
Serum Fetuin-A Is Associated With The Components Of Miac(Malnutrition, Inflammation, Atherosclerosis, Calcification) Syndrome In Different Stages, Rüya Mutluay, Ceyla Konca Değerteki̇n, Emel Işiktaş Sayilar, Ülver Deri̇ci̇, Serap Gülteki̇n, Sevi̇m Gönen, Seli̇m Turgay Arinsoy, Mahmut Şükrü Si̇ndel
Turkish Journal of Medical Sciences
Background/aim: Fetuin-A, a circulating inhibitor of calcification, is a marker of inflammatory-nutritional state. We evaluated the association between serum fetuin-A levels and vascular calcification, intima-media thickness, and nutritional and inflammatory markers in different stages of chronic kidney disease (CKD). Materials and methods: CKD patients were sampled for calcium-phosphate parameters and nutritional and inflammatory markers [highly sensitive C-reactive protein (hs-CRP)], and serum fetuin-A levels. Intima-media thicknesses of the common carotid arteries (CIMT) were measured. Peripheral artery calcification scores were obtained.Results: A total of 238 patients were included in the study. Fetuin-A levels in patients with end-stage renal disease were significantly lower …
Serum Zinc Levels In Seborrheic Dermatitis: A Case-Control Study, Ezgi̇ Aktaş Karabay, Asli Aksu Çerman
Serum Zinc Levels In Seborrheic Dermatitis: A Case-Control Study, Ezgi̇ Aktaş Karabay, Asli Aksu Çerman
Turkish Journal of Medical Sciences
Background/aim:Malassezia colonization, sebaceous gland activity, hormones, immune system defects, environmental factors, and the interactions between these factors are thought to contribute to the pathogenesis of seborrheic dermatitis (SD). Zinc, an essential element, is involved in many biological processes including the ones that contribute to the development of SD. The aim of this study is to evaluate serum zinc levels in patients with SD.Materials and methods: Forty-three patients with SD and 41 healthy controls were enrolled in the study. Disease activity was assessed by the Seborrheic Dermatitis Area and Severity Index by a single dermatologist. Serum zinc levels of all subjects …
Ifn-Γ Stimulated Dental Follicle Mesenchymal Stem Cells Regulate Activated Lymphocyte Response In Rheumatoid Arthritis Patients In Vitro, Noushin Zibandeh, Deni̇z Genç, Güzi̇de Nevsun İnanç, Rafi̇ Haner Di̇reskeneli̇, Tunç Akkoç
Ifn-Γ Stimulated Dental Follicle Mesenchymal Stem Cells Regulate Activated Lymphocyte Response In Rheumatoid Arthritis Patients In Vitro, Noushin Zibandeh, Deni̇z Genç, Güzi̇de Nevsun İnanç, Rafi̇ Haner Di̇reskeneli̇, Tunç Akkoç
Turkish Journal of Medical Sciences
Background/aim: Multipotent mesenchymal stem cells (MSCs) have been investigated in autoimmune diseases such as rheumatoid arthritis (RA) due to their immunomodulatory and regenerative properties. In this study, their immunosuppressive effects on peripheral blood mononuclear cells (PBMC) of RA patients were studied.Materials and methods: Dental follicle stem cells (DFSCs) were isolated from follicle tissue in the orofacial region. Characterization and multipotency analyses were performed. Lymphocytes were isolated from peripheral venous blood of RA patients (n = 5) and healthy individuals (n = 5). DFSCs were preincubated with IFN-γ for 48 h. PBMCs of RA patients and healthy individuals were separately cultured …
The Effect Of N-Acetylcysteine On Inflammation And Oxidative Stress In Cisplatin-Induced Nephrotoxicity: A Rat Model, İnayet Güntürk, Cevat Yazici, Sema Kader Köse, Fatma Dağli, Bi̇lal Yücel, Arzu Hanim Yay
The Effect Of N-Acetylcysteine On Inflammation And Oxidative Stress In Cisplatin-Induced Nephrotoxicity: A Rat Model, İnayet Güntürk, Cevat Yazici, Sema Kader Köse, Fatma Dağli, Bi̇lal Yücel, Arzu Hanim Yay
Turkish Journal of Medical Sciences
Background/Aim: Cisplatin is a highly effective chemotherapeutic agent used in the treatment of solid organ cancers. Besides its chemotherapeutic effectiveness, cisplatin administration is associated with numerous side effects. Of those, the most clinically significant and common effect is nephrotoxicity. Recent studies reported that oxidative stress and inflammation are probably the most important mechanisms that contribute to the nephrotoxicity. N-acetylcysteine (NAC) is an antioxidant and antiinflammatory agent. In the present study, the effects of NAC on cisplatin-induced nephrotoxicity were investigated. Materials and methods: Rats were divided into four groups each including eight rats: CONT, NAC-250, CP, and CP+NAC. Rats in experimental …