Medicine and Health Sciences Commons^™

Feasibility Of Improving Cone Beam Ct Number Consistency With A Scatter-Correction Algorithm, J. Li, W. Yao, Y. Xiao, Y. Yu

Bodine Journal

Purpose: To explore the feasibility of improving Elekta cone beam CT (CBCT) number consistency using a scatter-correction algorithm, with the aim of using CBCT images for treatment planning with heterogeneity correction.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Acute Neurological Toxicity (Nt) And Long-Term Outcomes In High-Grade Glioma Rtog Trials, Y. R. Lawrence, M. Wang, A. P. Dicker, D. W. Andrews, W. J. Curran, J. M. Michalski, L. Souhami, W. A. Yung, M. Mehta

Bodine Journal

Background: Treatment of high-grade glioma consists of fractionated radiation therapy (RT) ± chemotherapy. The incidence/significance of neurological toxicity (NT) in this disease is not known. We evaluated the relationship between acute and chronic NT, and ultimate outcome, as well as risk factors for NT from the RTOG database.

American Society of Clinical Oncology (ASCO) 46th Annual Meeting June 4-8, Chicago, IL.

Potential For Thermal Enhancement By Quercetin Mediated Mechanisms Targeting P53 Antagonists In Human Melanoma Cells, T. Thangasamy, K. Limesand, D. B. Leeper, R. Burd

Bodine Journal

Introduction: Recently Temozolomide (TMZ) has become the more commonly used analog of DTIC-related oral agents. Although the response rates achieved by TMZ alone are less than satisfactory, there is great interest in identifying compounds that could be used in combination therapy. We have previously demonstrated that the bioflavonoid quercetin (Qct) promotes a p53-mediated response in melanoma and sensitizes melanoma to DTIC. Here we demonstrate that Qct also sensitizes cells to TMZ by a mechanism that involves the modulation of a truncated p53 family member, ΔNp73.

Society for Thermal Medicine Annual Meeting April 23-26, Clearwater Beach, FL.

Control Of Glycolytic Flux By Ampk And P53-Mediated Signaling Pathways In Tumor Cells Adapted To Grow At Low Ph, E. E. Mendoza, J. Caro, D. B. Leeper, R. Burd

Bodine Journal

Introduction: Tumor cells grow in nutrient and oxygen deprived microenvironments and adapt to the suboptimal growth conditions by altering metabolic pathways. This adaptation process characteristically results in a tumor phenotype that displays anaerobic glycolysis, chronic acidification and aggressive tumor characteristics. Understanding the tumor cell reaction to the microenvironment is a critical factor in predicting the tumor response to hyperthermia. The glucose regulatory molecule, 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase Isoform-3 (PFKFB3), is a bifunctional enzyme central to glycolytic flux and downstream of the metabolic stress sensor AMP-activated protein kinase (AMPK), which has been shown to activate an isoform of Phosphofructokinase (PFK-2).

Society for Thermal Medicine …

Functional Antagonism Between Vorinostat And Temozolomide When Combined With Ionizing Radiation (Ir) In Glioblastoma, Y. R. Lawrence, Y. Liu, B. Andersen, X. Xia, A. P. Dicker, P. Wachsberger

Bodine Journal

Background: Glioblastoma is the most common primary adult brain tumor. Surgery followed by radiation therapy in combination with temozolomide (Tmz) produces a median survival of 14.6 months. Tmz is a DNA akylating agent that leads to the mispairing of guanine residues with thymine. An intact mismatch-repair mechanism (MMR) converts the mispaired thymine into a lethal double-strand DNA break. Vorinostat (SAHA), an HDAC inhibitor, has been shown to act as a radiosensitizer, possibly through inhibition of DNA repair. SAHA has successfully been combined with a number of cytotoxic agents. We hypothesized that SAHA would further potentiate the radiosensitizing properties of Tmz …

Effects Of Egfr Expression On Anti-Tumor Efficacy Of Vandetanib Or Cediranib Combined With Radiotherapy (Rt) In U87 Human Glioblastoma (Gbm) Xenografts, P. Wachsberger, Y. R. Lawrence, Y. Liu, A. P. Dicker

Bodine Journal

Introduction: Vandetanib is a receptor tyrosine kinase inhibitor (RTKI) with activity against vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR). Cediranib is a highly potent VEGF RTKI that inhibits all three VEGF receptors. In this study we investigated the effect of exogenous overexpression of EGFR on sensitivity of human GBM U87 xenografts to vandetanib or cediranib, alone or in combination with RT.

American Association for Cancer Research (AACR) 101st Annual Meeting April 17-21, Washington, DC.

Bodine Journal, Table Of Contents, Volume 3, Issue 1, Fall 2010

Bodine Journal

Table of Contents for Fall 2010 issue of Bodine Journal.

Is The Quality Of Neurosurgical Literature Improving?, James Harrop, Md, Mitchell Maltenfort, Phd

JHN Journal

Introduction:

The advent of evidence-based medicine has resulted in higher quality journal manuscripts in numerous medical disciplines. However, the impact in the neurosurgical literature has not been reported.

Objective:

To quantify the impact of evidence-based medicine on the quality of articles published in the Neurosurgery literature.

Methods:

Articles published in the journal Neurosurgery (founded in 1977) were reviewed for 1978, 1988, 1998, and 2008. Each decade’s sample was classified as therapeutic, diagnostic and prognostic based on a published system for determining level of evidence.

Results:

438 articles were reviewed. Articles not considered included any published under the heading “Case Report” …

The Patient Centered Medical Home: Federal, State And Local Initiatives To Transform Primary Care. The First Of An Occasional Series In Interprofessional Education And Care In The Patient-Centered Medical Home, Brooke Salzman

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

The Patient Centered Medical Home (PCMH) is rapidly emerging as one prototype for redesigning health care delivery, restructuring reimbursement, and reestablishing the critical value of primary care. The actual term “medical home” was introduced by the American Academy of Pediatrics, (AAP) in 1967, initially referring to a central location for archiving a child’s medical record. In 2002, the AAP expanded the medical home concept to include care characterized as accessible, continuous, comprehensive, patient-centered, coordinated, compassionate, and culturally effective. In 2004, the American Academy of Family Physicians (AAFP) embraced the model in its Future of Family Medicine project report, and in …

Jefferson Award For Excellence In Interprofessional Education

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

In recognition for outstanding contributions to interprofessional education two faculty awards were given by JCIPE to Christine Jerpbak, MD, Department of Family and Community Medicine on May 23, 2010 and E. Adel Herge, OTD, OTR/L , Department of Occupational Therapy on June 1, 2010.

Clinical Care Plan, Interprofessional Course, Marcia Levinson, Kathryn Shaffer, Amy Egras

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Evidence suggests interprofessional collaborative practice significantly improves patient outcomes, reduces mortality and enhances quality-of-life.1 Person-focused care demands collaboration among professions in a team approach to address multiple issues including illness, prevention, and health promotion activities. Key elements of successful implementation of interprofessional education are supported in Thomas Jefferson University’s Clinical Care Plan, Interprofessional Course (CCPIC) that includes increasing knowledge of the roles, responsibilities, and competencies of other health professions, collaborating in teams, recognizing the patient as the expert, and communicating effectively.

Developing Interprofessional Teams Using High Fidelity Resuscitation, Ksenia Zukowsky, Kevin Dysart, Brian Glynn, Tara Berman, Judi Ondik, Patricia Constanty, Debbie Cruz

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Interprofessional simulations using scenarios, megacodes, algorithms, and high fidelity equipment provide a closer approximation to what clinicians are likely to face as a team in the actual resuscitation of a newborn infant.

From The Editors, Christine Arenson, Md, Molly Rose, Rn, Phd

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Welcome to the latest edition of the Jefferson Interprofessional Education and Care Newsletter. In this issue, Dr. Zukowsky and colleagues describe the value of high-fidelity simulation to train interprofessional teams in high-risk high-stakes care. Their successful model has important implications for preparing teams to perform optimally during critical, and often stressful, clinical situations where expertise in both technical and team skills is imperative for best patient outcomes. Dr. Levinson and colleagues describe an exciting interprofessional care planning course which, for the first time at Jefferson, has brought senior Occupational Therapy (OT), Physical Therapy (PT), Nursing, Pharmacy and Medical students together …

Download Entire Pdf Interprofessional Education And Care Newsletter, Vol. 2, No. 1, Fall 2010

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

This issue includes articles on:

Developing Interprofessional Teams using High Fidelity Resuscitation

Clinical Care Plan, Interprofessional Course

The Patient Centered Medical Home: Federal, State and Local Initiatives to Transform Primary Care The First of an Occasional Series in Interprofessional Education and Care in the Patient-Centered Medical Home

JCIPE hosted its First International Interprofessional Education and Care Conference

Those Who Give: The Kristen Olewine Milke Breast Cancer Research Fund

Jefferson Surgical Solutions

No abstract provided.

Dr. Adam Berger Heads New Section Of Surgical Oncology

Jefferson Surgical Solutions

No abstract provided.

Meet Our Surgical Interns

Jefferson Surgical Solutions

No abstract provided.

Vascular Center Offers Leading- Edge, Integrated Care

Jefferson Surgical Solutions

No abstract provided.

Overview: Charles J. Yeo, Md

Jefferson Surgical Solutions

No abstract provided.

About The Surgeon

Jefferson Surgical Solutions

No abstract provided.

What Makes A Surgeon Of Choice: Dr. John Maxwell

Jefferson Surgical Solutions

No abstract provided.

Download Full Pdf Issue Of Jefferson School Of Population Health Master Of Public Health E-News Public Health Link, Vol. 6, Iss. 2, Summer 2010

Public Health Link

This issue includes a MPH spotlight on JoAnne Fischer, Executive Director of the Maternity Care Coalition (MCC). Other articles include: 13th Annual Health Education Advocacy Summit Student Perspectives, Health Reform Provides Major Benefits to Public Health summary, Food Inspection Opportunity, congratulations to Spring Capstone presenters, and information on 2 symposia: Symposium on Community Based Participatory Research on Chronic Disease Prevention and Symposium on National Public Health Week - One Community at a Time.

Download The Full Pdf Of Jefferson Surgical Solutions Spring 2010, Volume 5, Number 1

Jefferson Surgical Solutions

No abstract provided.

News In Brief

Jefferson Surgical Solutions

No abstract provided.

Jefferson Awards Gala Celebrates A Dedicated Faculty Member

Jefferson Surgical Solutions

No abstract provided.

On The Job-Katie Ashburn, Crnp, And Shawn Pierce, Cnrp

Jefferson Surgical Solutions

No abstract provided.

Brody Recognized For Promising Pancreatic Cancer Research

Jefferson Surgical Solutions

No abstract provided.

Please Welcome-Joyce Hartmann, Physician Liaison For Liver Transplant Program

Jefferson Surgical Solutions

No abstract provided.

The New Breast Care Center: Truly “Managed Care” For Women

Jefferson Surgical Solutions

No abstract provided.

Overview-Charles J. Yeo, Md Samuel D. Gross Professor And Chair, Department Of Surgery

Jefferson Surgical Solutions

No abstract provided.