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Yale Medicine Thesis Digital Library

Theses/Dissertations

2006

Adolescents

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Ethnic Differences In Intramyocellular Lipid Levels And Insulin Resistance In Obese Children And Adolescents, David Liska Jan 2006

Ethnic Differences In Intramyocellular Lipid Levels And Insulin Resistance In Obese Children And Adolescents, David Liska

Yale Medicine Thesis Digital Library

The prevalence of insulin resistance and type 2 diabetes mellitus (T2DM) in obese children and adolescents is growing at an alarming rate, especially in ethnic minorities. It is not clear whether young people of different ethnic backgrounds vary in their metabolic response to excessive adiposity. Differences in lipid partitioning in the abdominal fat compartments have been observed among different ethnic groups. The aim of this study was to evaluate whether there are ethnic differences in intramyocellular lipid (IMCL) levels that are related to differences in insulin sensitivity. Eighty-two obese children and adolescents underwent 1) 1H nuclear magnetic resonance (NMR) spectroscopy …