Medicine and Health Sciences Commons^™

Synthesis And Characterization Of Imidazolium Salt Derivatives For Anti-Tumor Activity, Ryan W. Pearce

Williams Honors College, Honors Research Projects

Several aldehydes (butanal, pentanal, hexanal, 4-hydroxybenzaldehyde) were reacted with 1,3-bis(naphthalen-2-ylmethyl)-imidazolium bromide (1) to produce novel C² substituted imidazolium salts for the potential use against non-small cell lung cancer in humans. Compounds 2-(1-hydroxypentyl)-1,3-bis(naphthalen-2-ylmethyl)-imidazolium bromide (3) and 2-(1-hydroxyhexyl)-1,3-bis(naphthalen-2-ylmethyl)-imidazolium bromide (5) were successfully synthesized with structures supported by NMR and mass spectrometry. Characterization by ¹H NMR showed evidence of 1 in both compounds. The tumor cell growth inhibition of 3 against non-small cell lung cancer lines NCI-A549, NCI-H460, HCC827, and NCI-H1975 was tested and found to be comparable to cisplatin as measured by MTT assay. …

Caregiver Perceptions Of Healthcare Providers And Environments Related To Children With Autism Spectrum Disorder, Deanna Klettlinger, Lynn Wirfel, Brittany Bielak

Williams Honors College, Honors Research Projects

The healthcare setting can be intimidating for any child. For children with autism spectrum disorder (ASD), in particular, this setting can cause anxiety and elicit disruptive behavior. The reactions of children with ASD to healthcare settings have not been widely studied. This study explores the lived experience of caregivers of children with ASD related to healthcare providers and environments. A qualitative phenomenological approach and methods guide the study. Purposive sampling was utilized at a resource center to identify and recruit participants fulfilling inclusion criteria. Sample size consisted of four female and two male adults. Semi-structured interviews were performed and voice …

The Effect Of Personal Contact On Attitudes Toward Mental Illness In Baccalaureate Nursing Students, Jessica Ashe

Williams Honors College, Honors Research Projects

Many people who suffer from serious mental illness also suffer from the stigma associated with such illness. Because nurses frequently come into contact with the mentally ill, it is important that they do not stigmatize these individuals. The purpose of this study is to determine the effect of a guest lecture by an individual with a serious mental illness on attitudes about mental illness in a sample of baccalaureate nursing students. The theoretical framework that guides this study is Goffman’s (1963) theory of social stigma. The sample used for this research is a convenience sample of 50 junior level nursing …

Amt Bridle Clip Re-Design, Andrew Lang, Frandy Cador, Boubacar Ide

Williams Honors College, Honors Research Projects

No abstract provided.

Effect Of Physical Activity On Perceived Quality Of Life Of An Individual With Cerebral Palsy, Julia R. D'Agostino

Williams Honors College, Honors Research Projects

Regular exercise has a variety of benefits. When incorporated into an individual’s daily routine, exercise contributes to better overall health, less stress, higher self-esteem, and decreased risks for secondary diseases. Cerebral palsy is caused by damage to the motor control center of the brain, resulting in physical impairment. Individuals with CP have limited means of exercise due to physiological, mental, and emotional obstacles. By incorporating regular exercise into their daily routines, individuals with cerebral palsy may gain physiological improvements, emotional and social benefits and improvements in overall quality of life. PURPOSE: To determine the effect that regular exercise has on …

Electronic Health Record Simulator, Samuel M. Brown

Williams Honors College, Honors Research Projects

The Electronic Health Record Simulator is exactly that; it is meant to simulate an EHR (like those found in hospitals and clinics) for use in an academic setting. Its purpose is to familiarize students with the operation of real-world EHRs in order to better prepare them for the workforce. It allows instructors to create fictional patients (with full lab values), and allows students to fill in information as in a real EHR.

Water Treadmill Versus Land Treadmill Training Effects On Leg Strength And Cardiovascular Endurance, Michelle E. Hudson Ms.

Williams Honors College, Honors Research Projects

Underwater treadmill running can be used as a means of reducing musculoskeletal loading while maintaining a training intensity equal to that of land running. A variety of cardiovascular benefits are seen in water running, such as greater increases in stroke volume and cardiac output than on land. Additionally, increased drag while water running can significantly improve force production. PURPOSE: To investigate if differences exist between underwater treadmill and land treadmill running on leg strength and cardiovascular endurance through a case study of two 22 year old sedentary males. METHODS: An 8-week aerobic training program was designed incorporating water …

Treatment Outcomes For The Mass Treatment Approach For Adults Who Stutter: A Case Study Assessment, Danielle Reymann

Williams Honors College, Honors Research Projects

No abstract provided.

Low Cost Shear And Pressure Sensor, Kyle L. Rohrig, Phaethon D. Kotantoulas, Brandon J. Lloyd, Hazim H. Abualola, Tao Ruan

Williams Honors College, Honors Research Projects

Elevated pressure and shearing stresses at the foot-shoe interface are believed to play a role in diabetic foot ulceration. The main goal of this project was to design a simple insole that could distinguish between sites of high pressure and sites of excessive shearing stresses at the foot-shoe interface. Wear patterns that relate specifically to shear and pressure acting on the plantar surface of a patient’s foot also needed to be exhibited. The team used reflective tape that was applied to the surface to various types of insoles to look for visible wear patterns. These wear patterns were identified by …

United States Food Insecurity And The Need For Improved Nutrition And Additional Nutrition Education In Local Food Assistance Programs, Carissa Hohider, Elizabeth Sain

Williams Honors College, Honors Research Projects

No abstract provided.

Literature Review And Case Study Of The Functionality Of Video Self Modeling, Carly Conklin

Williams Honors College, Honors Research Projects

This report includes a literature review and case study examination to determine the functionality and effectiveness of video self-modeling as a speech-language therapy technique for a child with autism spectrum disorder (ASD). Research has shown that video modeling is effective to teach language skills to individuals with ASD. This case study focused on teaching a child with ASD receptive language skills to identify emotions based on body language and tone of voice. A single subject pretest posttest design was used to measure the results for the case study participant.

Drug Interactions With Glutaredoxin Orthologues, Kahlilah R. Napper, Thomas C. Leeper, Ram Khattri, Daniel Morris, Caroline Davis

Williams Honors College, Honors Research Projects

Glutaredoxin, an enzymatic protein, is an important component of cell viability and function. It catalyzes reactions involved in DNA synthesis and innate immunity [1,4]. Glutaredoxin is also essential in antibiotic resistance in pathogenic bacterial species. Pseudomonas aeruginosa in particular is responsible for infecting the lung tissue of its human hosts, resulting in the development of pneumonia and cystic fibrosis [3]. Because glutaredoxin is pertinent in cell proliferation of eukaryotic and bacterial cells alike, medicinal fragments that take advantage of the subtle differences in protein structure of the orthologous proteins can be synthesized and enhanced to bind bacterial glutaredoxins, without inhibiting …

Survey Of Telepractice In Speech-Language Pathology Graduate Programs, Katie M. Constantine

Williams Honors College, Honors Research Projects

The purpose of this project is to gain knowledge on the rate of telepractice technology used in different speech-language pathology graduate school programs across the country. There is little information known about the training available to graduate students in the field of speech-language pathology. This study examined the current state of graduate level training in telepractice technology in speech-language pathology graduate programs.

The Challenges And Perceptions Of Raising A Child Who Uses Aac: A Review Of The Literature, Rachel M. Mikolay

Williams Honors College, Honors Research Projects

The purpose of this review was to examine the perceptions of parents and caregivers on raising a child who uses augmentative and alternative communication (AAC). Factors and overarching themes in existing literature affecting parent’s perceptions were examined and condensed in this review. Seven research studies were chosen for analysis. A variety of common perspectives were found in the research and the conclusions relating to caregiver challenges and thoughts on AAC were categorized, including four thematic categories: problems with the AAC system; barriers to learning AAC; societal, family, and professional influences; and differences among individuals who use AAC. Information gained in …

Geropsychiatric Medical Problems, Daniel Giorgio

Williams Honors College, Honors Research Projects

With a growing elderly population in the United States, the development of

efficient methods to ensure high-quality care for geriatric patients is more important than

ever. In the emergency department (ED), geriatric patients account for up to 24% of

stays. Many of these patients come to the ED for neuropsychiatric reasons and some are

admitted to geropsychiatric units. These patients require medical screening to identify

issues that may in part account for their mental state. The purpose of this study was to

characterize the patients who were admitted from the Summa Health System ED to

geropsychiatric units. It was hypothesized …

A Comparison Of Empathy In Sophomore And Senior Baccalaureate Nursing Students, Alexandra I. Woods, Stephanie Malachin

Williams Honors College, Honors Research Projects

Empathy is a cognitive process rather than an emotional and is often learned through life. Hildegard Peplau’s theory of interpersonal relations explains the importance of the nurse having a shared experience with the patient. Empathy is a crucial skill for nursing students to develop because it is shown that nurses showing empathy is directly related to improved patient satisfaction. Empathy levels tend to decrease as students progress throughout nursing school. The purpose of this study is to examine the empathy levels in sophomore baccalaureate nursing students compared to senior baccalaureate nursing students. Using a descriptive comparison design and a cross-sectional …

The Effects Of Land Vs. Aquatic Hiit Treadmill Running On Aerobic And Anaerobic Performance – A Pilot Study, Cory N. Egli

Williams Honors College, Honors Research Projects

The purpose of this study was to investigate how high intensity interval training (HIIT) performed on a land treadmill (LT) versus HIIT on an underwater aquatic treadmill (AT) would affect aerobic and anaerobic performance. The HIIT program consisted of running 8 intervals beginning with a 20 second workout and increasing exercise 5 seconds each interval until 55 seconds was reached. Ten seconds rest between each interval was protocol for a total interval running time of 5 minutes. The frequency of this training program was 3 times/week for 6 weeks. Nineteen college aged subjects were recruited, 13 subjects completed the program …

Assertiveness In Nursing Students, Kaitlin F. Amicone, Rachel Miller

Williams Honors College, Honors Research Projects

The problem that this study focused on was that there was minimal evidence on whether or not nursing students become more assertive throughout their academic education. The purpose of this study was to compare the assertiveness scores of sophomore level nursing students and senior level-nursing students. The study was guided by Hildegard Peplau’s theory of interpersonal relations in nursing, which focuses on the therapeutic process between nurses and patients, rather than on internal patient pathology. The descriptive, comparative study used a 15-question survey design and a convenience sample of sophomore and senior level nursing students at a large urban Midwest …

Freshman 15: How The University Of Akron Is Affected Per Residence Hall, Daniel G. Mcquillen

Williams Honors College, Honors Research Projects

Students entering their freshmen year of college face a variety of lifestyle changes. These changes often include increased caloric consumption, increased levels of stress, decreased physical activity, and increased alcohol consumption. Because of these lifestyle changes, it is commonly asserted that freshman gain weight throughout their first year in college. A common expression used to describe this weight gain is the “Freshman 15,” which asserts that the average student gains 15 pounds during their freshman year. PURPOSE: The purpose of this study was to gather data regarding the on-campus freshmen’s diet and exercise habits. The data gathered was used to …

Nutrition Educational Programming: An Added Step In The Integrated Healing Process Of The Residents Of The Battered Women's Shelter, Annalise Friend

Williams Honors College, Honors Research Projects

This honors project began as a conversation to explore the feasibility of including nutrition education into the health and wellness programming offered at the Battered Women’s Shelter of Summit and Medina Counties. As this population of women has unique needs and health concerns specifically associated with recovery from domestic violence, before planning for what nutrition education may be appropriate to implement, it is first necessary to explore the literature that discusses the health and nutritional needs of this population. Unfortunately, there is not a substantial amount of research available that examines this question, so there is still a lot left …

Body Image Differences Between University Students’ Major Of Study, Alissa C. Parsons

Williams Honors College, Honors Research Projects

Body image is a psychological feeling, which varies greatly based on factors including age, sex, and exercise participation. Body image is a critical factor to consider; positive body image is important in the prevention of health-related problems. PURPOSE: The purpose of this study was to investigate if body image differences exist among students (Exercise Science and Engineering majors) at The University of Akron. This comparative study examining students, representative of educational background, was to explore if students’ major study of focus affected body image. METHODS: A 14-item survey using the Body Image States Scale (BISS), with questions related …

Histological And Immunohistochemical Analyses Used To Study Craniosynostosis In Pediatric Patients, Palvir Kaur Baadh

Williams Honors College, Honors Research Projects

Craniosynostosis is a condition in which one or more of the sutures of the skull grow together (fuse) earlier than normal in infants. Sutures are large gaps located at the bony plates or joints of the head. Craniosynostosis causes the skull to expand and grow in the direction of any normal open suture, creating craniofacial complications, such as drooping eyelids and abnormal intracranial pressure, head shape, or brain morphology. This premature fusion or ossification of sutures affects approximately 300-500 live births in 1,000,000 (Kolpakova-Hart et al., 2008) with considerable variation in phenotype, depending on which suture(s) is involved. Corrective …

Multi-Modal Communication In School-Age Children With Autism Spectrum Disorders, Lauren Dougherty

Williams Honors College, Honors Research Projects

Children with Autism Spectrum Disorder (ASD) have a difficult time communicating on a daily basis. To help enhance and sometimes substitute speech altogether, they require Augmentative and Alternative Communication (AAC) devices. A review of literature found that school-age children with ASD utilize multiple modes of communication. The observation conducted looked at six school-age children, grades 6-8, with ASD and their use of multimodal communication. Each child was observed throughout their school day in settings such as the classroom, lunch/recess, and the speech therapy room. Data was collected for the number of times a child was given the opportunity to use …

Polymer Interactions With Nucleic Acids Under Various Physiological Conditions, Matthew S. Obrzut

Williams Honors College, Honors Research Projects

The goal of this project is to improve our understanding of nucleic acid interactions with cationic polymers with the theory that the polymers could protect the nucleic acids from degradation caused by biological enzymes. We seek to understand what the limitations of the cationic polymers are which, in this case, is mainly polymer-DNA compatibility. This experiment utilized peptide-dextran hybrid polymers with differing functionalizations to condense anionic nucleic acids into nanometer-sized polyplexes. Techniques of dynamic light scattering and zeta-potential were utilized to determine the particle sizes and surface charges of polyplexes.

In this experiment, dextran with a molecular weight of 20 …

The Effects Of Sustainability As A Positive Attribute On Equine Therapy Design: An Interdisciplinary Study, Andria Sinclair

Williams Honors College, Honors Research Projects

Interdisciplinary studies have brought benefits to introducing new solutions to the traditional environment and traditional therapies. Sustainability in relation to design has been suggested in 2006, by the Center for Building Performance and Diagnostic (CBPD) at Carnegie Mellon University to incorporate daylight, solar, heat and ventilation of the natural environment combined with the innovations of current technologies (Whitmore, 2011). This paper will look at how sustainability plays a key role of benefits including those that are health associated with equine therapy design and its relationship to the patient, or end user. Interdisciplinary research in the therapeutic value of equine-human bonding …

Honoring The Victims: How The Change In Ethics Ruined Science In The Third Reich And What To Do With The Remaining Medical Data, Kathleen M. Mitchell

Williams Honors College, Honors Research Projects

This paper analyzes both sides of the debate over using the Nazi medical data and brings forth one possible compromise. While using the data can provide the scientific community information that can be beneficial for society—and thus salvaging some good out of the evil—are the survivors’ sentiments on the subject truly being heard? The idea that the victims are once again being abused by using the information without their consent is not a matter to be taken lightly. On the other hand, if the data is valuable, it can be detrimental to scientific experimentation to deny access or destroy the …

Wellness Wednesday: Monitoring Lifestyle Changes Via The Transtheoretical Model, Mariah J. Bloom Ms.

Williams Honors College, Honors Research Projects

Physical activity has been shown to improve cognition, functional and overall health indicators across the lifespan. Older adults are less likely to participate in physical due to barriers and risk related factors. Additionally, lower income, underserved populations experience added barriers as well. Interventions addressing negative health behaviors in these populations have rarely been implemented. PURPOSE: Using the Transtheoretical Model (TTM) behavior change theory, the purpose of this study was to determine if five, monthly educational and exercise classes targeting these populations will improve motivation levels and result in facilitating increases in physical activity levels. METHODS: One validated TTM survey was …

A Systematic Review: Immediate And Maintenance Effects Of Interventions On Handwashing Compliance In Healthcare Workers, Brent E. Gibson, Dajana Markovic

Williams Honors College, Honors Research Projects

There has been a drastic rise in the number of nosocomial infections of patients in intensive care units. Handwashing is generally accepted as an effective and inexpensive method that healthcare providers in hospital settings can use to decrease the likelihood of nosocomial infections, however, studies have shown that healthcare providers are often not compliant with handwashing protocol. The purpose of this systematic review of literature is to not only obtain information on handwashing compliance and non-compliance among different healthcare providers, but also to identify, describe, and evaluate evidence about the effect of various interventions on handwashing compliance in healthcare providers. …

Puzzling Your Puzzler, Samantha Brown

Williams Honors College, Honors Research Projects

The following is summarizing a proposed experimental study based on current literature review and research to evaluate a new interventional therapy for the treatment of concussion compared to current therapeutic practices.

Background and Purpose: Concussions have become a major concern in the medical field in recent years. Several research studies have been conducted to learn the signs and symptoms regarding concussions. Recent literature has found that the signs and symptoms of a concussion are similar to those of patients suffering from Alzheimer’s disease. Treating Alzheimer’s disease has changed in recent years. Research has found that mental rehabilitation, also known as …

Therapeutic Animal Camp For Children Affected By Cancer, Katie Fleck

Williams Honors College, Honors Research Projects

This research project looks at the therapeutic benefits of an animal camp for children touched by cancer. Animal assisted therapy techniques were used for children to connect with animals during a week long summer camp. The benefits of working with animals are discussed, as well as research on many therapeutic activities including reiki, labyrinth walking, zentangle drawing, yoga, and drumming. Past camp attendees were recorded and interviewed about their personal experiences at camp. Caregivers of campers were also interviewed, who shared about the positive impact camp had on their family. Multiple benefits were found for this type of camp in …