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Inhibitory Role Of Sphingosine 1-Phosphate Receptor 2 In Macrophage Recruitment During Inflammation, Jason Michaud, Timothy Hla, Dong-Soon Im

UCHC Articles - Research

Macrophage recruitment to sites of inflammation is an essential step in host defense. However, the mechanisms preventing excessive accumulation of macrophages remain relatively unknown. The lysophospholipid sphingosine 1-phosphate (S1P) promotes T and B cell egress from lymphoid organs by acting on S1P receptor 1 (S1P₁R). More recently, S1P₅R was shown to regulate NK cell mobilization during inflammation, raising the possibility that S1P regulates the trafficking of other leukocyte lineages. In this study, we show that S1P₂R inhibits macrophage migration in vitro and that S1P₂R-deficient mice have enhanced macrophage recruitment during thioglycollate peritonitis. …