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Full-Text Articles in Medicine and Health Sciences
Functional Polymorphisms In The Serotonin 1b Receptor Gene (Htr1b) Predict Self-Reported Anger And Hostility Among Young Men, Kevin P. Jensen, Henry M. Furneaux, Howard A. Tennen, Henry R. Kranzler, Jonathan Covault
Functional Polymorphisms In The Serotonin 1b Receptor Gene (Htr1b) Predict Self-Reported Anger And Hostility Among Young Men, Kevin P. Jensen, Henry M. Furneaux, Howard A. Tennen, Henry R. Kranzler, Jonathan Covault
UCHC Articles - Research
Objective To examine associations between haplotypes of the serotonin 1B receptor gene and individual differences in anger and hostility. Methods Data were analyzed from a study of 361 university students (47% male). Participants were genotyped at 5 polymorphisms in the HTR1B gene (rs11568817, rs130058, rs6296, rs6297, rs13212041), including promoter and 3′UTR polymorphisms with opposite functional effects on gene expression. Participants reported their emotional states across 30 consecutive days for up to four years. Haplotype pairs were constructed statistically and assigned to a level of HTR1B expression based on the presence of the functional polymorphisms. Results Six haplotypes accounted for >97% …