Medicine and Health Sciences Commons^™

Glycemic Variability In Patients With Stage Ii-Iii Colon Cancer, Natalie Mandolfo

Theses & Dissertations

Patients with cancer experience metabolic changes such as hypoglycemia, hyperglycemia, and glycemic variability; collectively termed malglycemia. Glycemic variability, defined as fluctuations in glucose, is a marker of metabolic instability. Higher glycemic variability is associated with adverse health outcomes in the general population and in those with diabetes. Little is known about glycemic variability in patients with cancer, especially those with solid tumor malignancies. Glycemic variability is associated with increased infection, shorter periods of remission, and higher mortality in patients with hematological cancer. This body of work describes the concept and measurement of glycemic variability to assess glycemic control in patients …

Temporal Pain Pattern Sequencing In The Older Adult After Joint Replacement Surgery, Jennifer B. Withall

Theses & Dissertations

Background

Large joint replacement surgery, including hip and knee arthroplasties, are two of the most common surgical procedures that American adults aged 65 years and older undergo annually. While postoperative pain is expected, if it is not properly managed, it can have deleterious effects on postoperative recovery, including an increased length of stay, increased risk for postoperative complications, and decreased patient satisfaction.

Problem

Postoperative pain is primarily managed pharmacologically, typically with opioid pain medications are administered as needed (i.e., pro re nata [PRN]). Patients request pain-relieving medications when they are experiencing escalating pain, which can be challenging to maintain comfort …