Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Mechanical Factors Affecting Heart Morphogenesis, Moshe Fenster
Mechanical Factors Affecting Heart Morphogenesis, Moshe Fenster
The Science Journal of the Lander College of Arts and Sciences
For years, the genetic element of heart morphogenesis has been studied. This review focuses on a relatively new area of study, namely, mechanical factors influencing heart morphogenesis. To understand the context of the role of mechanical factors in heart development, an extensive review of the stages of heart morphogenesis is provided. It is found that shear stress, surface tension, fluid forces, and contractions of certain cells play a role in various stages of heart development. Numerous studies have shown that in cases where these mechanical forces were modified, abnormal heart defects were produced. These studies prove that the mechanical forces …
Cardiac Jelly And Its Roles In Heart Development, Sara Zucker
Cardiac Jelly And Its Roles In Heart Development, Sara Zucker
The Science Journal of the Lander College of Arts and Sciences
The following is the introduction to this article: The complexity of the developing and functioning heart has always intrigued scientists. One of the many ambiguous areas in the understanding of cardiac development is the role of a gelatinous substance commonly referred to as cardiac jelly, (Davis, 1924) and more recently the myocardial basement membrane (Little and Rongish, 1995). Researchers have been studying this material to determine its roles. Their studies led them to believe that this jelly-like substance may be involved in vital embryological roles including the actual morphogenesis of the heart, such as heart valve formation and pumping. When …