Medicine and Health Sciences Commons^™

Avaren-Fc, A Novel Immunotherapeutic, Recruits Nk Cells In B16f10 Melanoma Tumor Tissue, Sreevatsa Vemuri, Katarina Mayer, Nobuyuki Matoba

Posters-at-the-Capitol

Melanoma is the fifth most common cancer in the US, with limited effective immunotherapeutic options available for patients. Avaren-Fc (AvFc) is a novel experimental immunotherapeutic agent with a unique “lectibody” property. It is capable of targeting cancer cells through the selective recognition of high mannose glycans, which are aberrantly overrepresented on the surface of malignant cells. AvFc can interact with circulating effector immune cells equipped with Fc receptors, such as natural killer (NK) cells to induce antibody-dependent cell-mediated cytotoxicity (ADCC) and kill cancer cells. Previous work has shown that AvFc effectively induces ADCC activity against B16F10 cancer cells in vitro …

Enhancing The Safety Of Medication Administration: The Synergistic Role Of Closed Loop Electronic Medication Management And Iv Medication Administration, Kelly Goetz, Angela Schoenung, Lauren Daugherty, Kaitlyn Hornsby

Posters-at-the-Capitol

The high acuity of patients in the ICU results in numerous medications being administered, increasing the risk of medication errors. The purpose of this project is to investigate the impact of integrating consistent closed loop electronic medication management (CLEMM) to decrease medication errors in the ICU for bedside nurses who use electronic health records (EHRs). The project type is a comprehensive literature review, with studies that included a single prospective cohort study, case report, single non-randomized trial, quasi experimental study, single cross-sectional studies, and systematic reviews. The importance of this project is to address the break in the loop of …

Reactive Chlorine Species Reversibly Inhibit Dnab Protein Splicing In Mycobacteria, Daniel R. Wahl, Christopher W. Lennon

Posters-at-the-Capitol

Intervening proteins, or inteins, are mobile genetic elements that are translated within host polypeptides and removed at the protein level by splicing. In protein splicing, a self-mediated reaction removes the intein, leaving a peptide bond in place. While protein splicing can proceed in the absence of external cofactors, several examples of conditional protein splicing (CPS) have emerged. In CPS, the rate and accuracy of splicing are highly dependent on environmental conditions. Because the activity of the intein-containing host protein is compromised prior to splicing and inteins are highly abundant in the microbial world, CPS represents an emerging form of posttranslational …

Screenings To Decrease Pediatric Suicide, Jordan Bridges, Dana Schildmeyer, Amanda Austin, Laura Boesken

Posters-at-the-Capitol

This project aimed to examine the current practice related to mental health and depression screenings in pediatric patients. The benefits of implementing screening in schools in identifying depression and suicide risks sooner were also considered. This project focused on the correlation between earlier mental health screening and identification of these mental health disorders earlier in the life of pediatric patients and suicide rates. Current, published literature notes mental health screening in the pediatric population in schools is an effective method to facilitate monitoring and early intervention in detecting a mental illness. Schools implementing mental health screenings can result in increased …

Home Visitation To Prevent And Reduce Postpartum Depression, Anna Bauer, Madison Polley, Laura Boesken Dnp, Msn, Rn

Posters-at-the-Capitol

Postpartum depression (PPD) occurs in 13-19% of women worldwide, and is a stigmatized medical condition affecting maternal and infantile long term outcomes. The purpose of this evidence-based practice project was to determine if women at high risk for PPD are affected by home visitation programs from discharge up to three years postpartum. CINHAL Ultimate, Google Scholar, and Medline databases were used. Current evidence supports the use of home-visitation programs for postpartum women to decrease the prevalence and the symptoms of PPD by allowing nurses access into homes to provide early intervention for PPD. In addition to providing care for prevention …

Uncovering The Role Of Cancer Associated Fibroblasts In Tumor Immunosuppression, Kamal Amirneni, Kavitha Yaddanapudi

Posters-at-the-Capitol

Current advances in cancer immunotherapy are hindered by the immunosuppressive nature of the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are a key component of the TME that contribute to suppressing the immune response. Chemokines and cytokines released by CAFs, such as IL-6, attract circulating monocytes which are converted into myeloid-derived suppressor cells (MDSCs). MDSCs suppress T-cells and natural killer cell proliferation which inactivates the immune response and deters immunotherapy. Both Prostaglandin E₂ (PGE₂) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been implicated in the CAF immunosuppressive pathway, but a causal link has yet to be established. We hypothesized …

Phase 1a Clinical Study For Q-Griffithsin Intranasal Spray For Prevention Of Coronavirus, Megan Bezold, Kenneth Palmer, Nobuyuki Matoba, Elizabeth Cash

Posters-at-the-Capitol

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible virus that causes acute respiratory disease with possible long-term complications, known as coronavirus disease 2019 (COVID-19). Griffithsin (GRFT; including the oxidation-resistant variant Q-GRFT used in this study) is an algal carbohydrate-binding protein exhibiting antiviral effects against many enveloped viruses, including all major variants of SARS- CoV-2 reported to date. Q-GRFT has been recombinantly manufactured in Nicotiana benthamiana plants, thoroughly purified, and formulated as an intranasal spray designed to be developed as a non-vaccine broad-spectrum prophylactic product for acute use. This is the first-in-human, randomized, double-blind, placebo-controlled study. The …

Breadth Of Vaccinated Cancer Patient Humoral Response To Sars-Cov-2 Spike Protein And Rbd Variants, Julia Corman, Joey Breckenridge Jr., Adrienne M. Bushau-Sprinkle, Krystal T. Hamorsky, Joshua L. Fuqua

Posters-at-the-Capitol

SARS-CoV-2, the virus responsible for the COVID-19 of which several variants have emerged, such as the B.1.351 SARS-CoV-2 variant. The Receptor Binding Domain (RBD), located within the Spike protein is an immunogenic epitope for potent neutralizing antibodies. Current mRNA vaccines encode for the Spike protein, allowing the body to build antigen-specific antibodies. Assays measuring protective antibodies are essential to manage the COVID-19 pandemic and can be used as a platform for variant screening. RBD-foldon 2.2 is a novel antigen produced by fusing RBD with the trimerization domain Fibritin from Bacteriophage T4. Its amino acid sequence is based on the original …

The Effect Of A Vegetation Buffer On Sound Levels, Madison Cicha

Posters-at-the-Capitol

Noise pollution is a growing concern in the environmental health community. Unlike other common exposures, such as air and water pollution, noise is uniquely difficult for an individual to protect themselves from. Studies have shown multiple adverse health outcomes resulting from exposure to noise pollution, including hearing impairment, negative social behavior and annoyance, sleep disturbance, along with a strong association between noise pollution and high cardiovascular risk. It is important, then, to look for solutions to this exposure. This study is designed to assess the effects of a tree barrier in reducing traffic noise. Noise monitoring was conducted at Saint …

Pulsed Chronopotentiometry With Polymer-Based Potassium-Selective Electrodes, Roland A. Long, Kebede L. Gemene Dr.

Posters-at-the-Capitol

This research aimed to develop ion-selective electrodes selective to potassium for use in measuring potassium concentration in blood. Potassium is an important electrolyte within the body, orchestrating nerve excitation, muscular function, and heart rate. Excessive or insufficient potassium levels can cause breakdowns in these systems difficult to differentiate from other potential causes. Isolating potassium concentration as the sole cause necessitates selective measurement. Pulsed Chronopotentiometry with polymer-based membrane electrodes offered a versatile route of interrogation: membrane composition and magnitude of applied current can be altered to assess selectivity in a fast and controlled manner. All potential measurements recorded corresponded to known …

Effects Of Covid-19 On Kentucky Air Pollutant Levels, Sarah Hartman, Ritchie Taylor, Jacqueline Basham

Posters-at-the-Capitol

The COVID-19 pandemic is the first of the 21^st century. Nearly 100 years ago, the Spanish Flu killed nearly 50 million people worldwide, including an estimated 675,000 people in the US.₁₂ COVID-19 has proved a deadly disease as well, with nearly 28.1 million cases and 496,000 deaths in the US alone as of February 20^th, 2021.₄ Only a few studies have been conducted regarding air quality response before and after the start of the pandemic. The study found that the NO2 levels decreased and the PM levels also decreased from before to after the beginning …

Cyberbullying And Teenage Mental Health, Emma Renfro, Melony Shemberger

Posters-at-the-Capitol

Abstract Cyberbullying is something that is becoming prevalent in today’s digital society. It is something that impacts more than one age group, but the primary age group seems to be aged 13-18. As a society, it is recognized that cyberbullying happens. However, how often does one stop to think deeper? In this research, I will approach cyberbullying from a mental health standpoint. I will demonstrate things such as why certain demographics are more susceptible to the impact of cyberbullying, what mental illnesses are caused by cyberbullying, and present statistics that, hopefully, motivate people to begin to combat this issue. Over …

Determination Of Cannabinoids, Cathinones, And Synthetic Fentanyls Using Wastewater-Based Epidemiology, Catherine O'Rourke, Bikram Subedi

Posters-at-the-Capitol

Unregulated new psychoactive substances (NPS) in “pure” or “preparation” forms are designed to mimic the effects of controlled substances, and are introduced and reintroduced in the market as a cheap substitute for established regulated drugs in quick succession to loophole the law enforcement efforts on combating drugs. For example, carfentanil, a synthetic opioid activates the opioid receptors similar to morphine but it is astoundingly potent compared to a typical drug of abuse (100 times more potent than fentanyl and 10,000 times more powerful than morphine). Based on the cost- and time-intensive forensic analysis, National Drug Early Warning System reported the …

Cannibidiol (Cbd) Supplementation In Horses: A Pilot Study, Kiara Jones, Evan Thomas, Shea Porr

Posters-at-the-Capitol

Cannibidiol (CBD) is sold for various uses in humans and animals. Thus far, CBD has not demonstrated effects similar to delta-9 tetrahydrocannabinol (THC), the psychoactive component of marijuana. While some animal species have demonstrated responses to CBD supplementation, published literature on equines is absent. The lack of FDA approval and studies to support claimed benefits make regulating product quality and recommending dosages difficult. The objectives of this project were to: 1) determine dosages that allowed for CBD detection in equine blood; and 2) evaluate time required for the appearance of maximum concentration and half-life of CBD in equine blood. Two …

Opioid And Non-Opioid Prescribing Rates For Ankle Fractures In Emergency Departments Across The United States Between 2006 And 2015, Lucy C. Bowers, Kyle B. Kosik Phd, Atc, Matt C. Hoch Phd, Atc, Phillip A. Gribble Phd, Atc, Alejandro G. Villasante Tezanos

Posters-at-the-Capitol

Context: An ankle fracture is a common injury observed in the Emergency Department (ED) and is often treated conservatively or surgically, depending on whether the fracture is stable. Opioids provide value for the management of acute musculoskeletal pain. However, prolong opioid use is associated with well-known consequences in the United States such as dependence, abuse and/or misuse. Considering these concerns and the effectiveness of non-pharmacological interventions for the treatment of acute pain, it is critical to identify the prescribing patterns for patients diagnosed with an ankle fracture in the ED. Objective: Describe the percentage of patients prescribed a …

Quality Of Care Strategies And The Subsequent Improvement Of Kangaroo Care Incidence Rates In Premature Infants, Sarah Anderson

Posters-at-the-Capitol

Purpose: The benefits of kangaroo care (KC) has long been studied and proven. Despite the research, incidence rates of KC are low in the neonatal ICU at the Kentucky Children’s Hospital. Some barriers to KC exist in our NICU and this study strives to address them. This study aims to develop and implement strategies to increase utilization of KC from 41% to  75% for eligible infants.

Methods: KC occurrence was monitored in 364 infants with birth weight ≤ 1250 grams. Strategies implemented were education of nurses, improved nurse-to-patient ratio, emphasis of KC in multidisciplinary rounding, improved documentation, …

An Evidenced-Based Protocol For Eliminating Errors Associated With Intravenous Medication Errors, Susie Chaney, Blake Smith, Andrea Howard, Chanel Wilder, Suzi White Msn, Phcns-Bc

Posters-at-the-Capitol

The purpose of our research is to decrease the number of IV medication errors. IV medication errors occur due to the wrong drug, wrong dose, wrong rate, wrong concentration, incorrect aseptic technique, known allergies, omitted medications, wrong time of administration, incorrect labeling, patient identification, and no order for the infusion. Nurses’ perceptions of why medication errors occur included physicians’ medication orders are not clear, the names of many medications are similar, pharmacy did not label the medication correctly, poor communication, lack of staff to patient ratio, fatigue from hard work, nurses' heavy workload, and working night shift. This quality improvement …

Are Dietary Factors And Exercise Levels Related To Fertility Status?, Britt Fugmann, Rachel Tinius

Posters-at-the-Capitol

BACKGROUND: Infertility is a major public health concern as it affects up to 25% of couples in Western Countries. While there is some evidence that diet and exercise may be linked to fertility, there is no official dietary or exercise guidance for couples when trying to conceive. Additional information regarding the relationship between diet, exercise, and fertility is needed to better inform the development of guidelines for couples trying to conceive.

PURPOSE: To examine the relationships between diet, exercise, and fertility among women.

METHODS: Participants were selected from on ongoing pregnancy study (N=33). All participants went on to have healthy …

Experiential Learning Through The Health & Wellness Peer Education Program, Matthew T. Allen, Christian R. Barefield

Posters-at-the-Capitol

The Health and Wellness Peer Education program was established on the Murray State University campus during the Fall 2016 semester. The purpose of this program is to empower and engage the campus community through outreach and advocacy to help make Murray State a healthier and safer environment for all students. The National Peer Educator Study (2011) found numerous benefits to having peer educator programs on college campuses. One of those benefits is that undergraduate peers are the single most potent source of influence on undergraduate student's affective and cognitive growth and development. Students often feel more comfortable when learning and …

Motor Development And Skill Acquisition In Elementary Aged Students, Joanna M. Guerrant Ms.

Posters-at-the-Capitol

Mastering physical movement occurs through motor learning and experience. Motor development is needed for successful acquisition of sport and other physical skills. A lack of motor skills has been associated with decreased physical activity later in life, which has been linked to a variety of hypokinetic diseases. This study examined motor learning and skill acquisition in elementary age children. Twenty 2^nd-5^th grade students were recruited through the local school system. Subjects did not have any injuries that would preclude them from performing three basic skills (modified squat, tree, and arm and leg raises). IRB approval, parental consent, …

Putting The Athletic Back In The Trainer, Shelby L. Davis

Posters-at-the-Capitol

Athletic Training Students are taught about the benefits of physical activity and how to create specific exercise programs to maintain overall wellness. Although athletic training students have knowledge about the positive effects of physical activity, they continually score lower on activity level scales when compared with the average college student. A rigorous course schedule and long clinical hours seem to be a common factor that play into the poor health habits of the athletic training student. Therefore, the purpose of this study is to determine the variables that negatively affect the exercise habits of undergraduate athletic training students.

Students from …

Hesi: A Quality Improvement Study, Sarah C. Locke, Jalpaben B. Patel

Posters-at-the-Capitol

HESI: A Quality Improvement Study

Dr. Jessica Naber

Jalpaben Patel and Sarah Locke

Murray State University School of Nursing

Abstract

Health Education Systems Incorporated (HESI) is an Elsevier company that provides educational material and exams that aim to improve nursing education and pass rates on the nurse-licensing exam (NCLEX). Numerous studies have examined the relationship between HESI exams and NCLEX pass rates in various nursing programs throughout the country. However, improving the implementation of HESI in nursing programs has not been the focus of much research. The purpose of this study was to identify possible improvements that could be made …

Emergency Education To Students In A Rural Healthcare Area, Stacie L. Hearell

Posters-at-the-Capitol

Stacie Hearell

Murray State University, Department of Nursing

Emergency Education to Students in a Rural Healthcare Area

Dr. Jessica Naber

Abstract

The purpose of this research process was to bring emergency healthcare education to advanced students in their Junior and Senior years of high school. The subjects were students enrolled in an advanced physical education program at local rural high schools. A pre-test was given to each student involved to assess their skills involving basic healthcare and how to respond in an emergency situation. The topics covered in the presentation were emergency room etiquette and processes, treatment for basic injuries …

Higher Unsaturated Fatty Acid Intake And Aerobic Training Are Related With Lower Intramyocellular Lipid In Older Adults, Hillary D. Mclean

Posters-at-the-Capitol

Title: Higher Unsaturated Fatty Acid Intake and Aerobic Training are Related to Lower Intramyocellular Lipid in Older Adults

¹Hillary McLean, ²Maja Redzic, and ³D. Travis Thomas

Department: ¹Department of Agriculture, ²Department of Pharmacology and Nutritional Sciences, and ³Department of Clinical Sciences

Funding: R21AG046762-01A1, UL1TR000117, T32DK007778-16

Word Count: 298/300

Intramyocellular lipid (IMCL) is associated with metabolic dysfunction in aging. Exercise is known to influence IMCL accumulation and was recently observed to have a direct association with vitamin D status (25(OH)D) in our lab. In addition, we observed an inverse association between IMCL and dietary unsaturated …

The Emerging Genetics Workforce: A Study Of Physician Geneticists' Professional Lives, Heather Gosnell

Posters-at-the-Capitol

PURPOSE: The purpose of this study is to explore the current practice and geographic location trends of physicians certified in clinical genetics, clinical biochemical genetics, and medical biochemical genetics during the 2011, 2013, and 2015 certification cycles.

METHODS: Physicians’ personal data was collected from public internet domains including the American Board of Medical Genetics and Genomics (ABMGG) provider database, the CMS National Plan and Provider Enumeration System, publically available professional-biographies, and university affiliations. The search results were cross-referenced for the greatest accuracy. Geographic location data was plotted onto maps.

RESULTS: Approximately 27% (n=69) physicians board-certified in genetics are currently practicing …

Brainwave Signatures For Detecting Malingered Neurocognitive Deficit (Mncd), Esias K. Bedingar

Posters-at-the-Capitol

Traumatic brain injury is a major public health concern in the United States, affecting up to 1.7 million people each year. Mild traumatic brain injury (mTBI) accounts for 80% of these cases. Various tests have been created in order to document brain injury and evaluate cognitive functions. However, neuropsychologists report that up to 40% of individuals undergoing evaluations following mTBI may be malingering deficits. This points to a need for innovative and non-invasive approaches to validating mTBI while identifying malingerers.

The aim of this study was to utilize neuroimaging and behavioral approaches to detect MNCD by comparing the reaction times …

Cervical Cancer Infrastructure, Knowledge And Attitudes In Kabale, Uganda, Nicole Robertson

Posters-at-the-Capitol

Cervical Cancer Infrastructure, Knowledge and Attitudes in Kabale, Uganda

Nicole Robertson¹, ShaCoria Winston², Kara Miller³, Julia Hanebrink⁴

¹University of Louisville ²Washington University in St. Louis ³University of California Riverside ⁴Christian Brothers University, Department of Anthropology

Cervical cancer has increasing prevalence in southwestern Uganda and is the most common cancer among women in sub-Saharan Africa. Despite this increased prevalence, the biomedical infrastructure in Uganda lacks support for cervical cancer screening and treatment. At the same time, cervical cancer carries a stigma as an incurable sexually transmitted disease similar to the …