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Full-Text Articles in Medicine and Health Sciences
Is Combination Nivolumab And Ipilimumab Safe And Effective In Patients With Melanoma?, Jacob L. Toscano
Is Combination Nivolumab And Ipilimumab Safe And Effective In Patients With Melanoma?, Jacob L. Toscano
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this selective EBM review is to determine whether or not combination nivolumab and ipilimumab is safe and effective in patients with melanoma.
Study design: Review of two randomized controlled trials (RCTs) published in 2015, and one cohort study published in 2013.
Data Sources: All of the articles were published in English language, peer reviewed journals and were found using PubMed and Cochrane databases.
Outcomes Measured: The safety of combination nivolumab and ipilimumab was measured by treatment-related grade 3 or 4 adverse effects. The effectiveness was measured by progression-free survival, which is based …
Do Braf Inhibitors Improve Survival In Patients With Braf V600e Mutant Melanoma?, Sarah E. Stamm
Do Braf Inhibitors Improve Survival In Patients With Braf V600e Mutant Melanoma?, Sarah E. Stamm
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Do BRAF inhibitors improve survival in patients with BRAF V600E mutant melanoma?”
STUDY DESIGN: Review of primary literature sources that examined survival rates in BRAF V600E mutant melanoma patients receiving treatment with a BRAF inhibitor.
DATA SOURCES: Two randomized controlled trials and one cohort study evaluating the use of BRAF inhibitors in patients with BRAF V600E mutant melanoma were found using OVID, Medline, and PubMed.
OUTCOMES MEASURED: Overall survival and progression free survival were the outcomes measured to determine survival rates in patients with BRAF V600E …
Is Ipilimumab An Effective Treatment In Patients Diagnosed With Metastatic Melanoma?, Melissa E. Hansen
Is Ipilimumab An Effective Treatment In Patients Diagnosed With Metastatic Melanoma?, Melissa E. Hansen
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this selective EBM review is to determine whether or not ipilimumab is an effective treatment in patients diagnosed with metastatic melanoma.
Study Design: Review of three English primary studies published between 2009 and 2010.
Data Sources: Randomized, controlled, double-blind clinical studies comparing ipilimumab +/-gp100 peptide to a placebo +/- gp100. Studies were found using PubMed and Cochrane databases.
Outcomes Measured: Each of the studies measured outcomes of disease progression and overall survival. Response rate to treatment was also measured in two studies. Measurement of these outcomes was achieved utilizing the following classifications systems: [TNM] categorization, & …