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Full-Text Articles in Medicine and Health Sciences
Biomarkers In Sepsis, Ahmed A. Abdelaziz, Hatem A. Atalla, Mohammed A. M. Ragab
Biomarkers In Sepsis, Ahmed A. Abdelaziz, Hatem A. Atalla, Mohammed A. M. Ragab
Menoufia Medical Journal
Objectives To perform a systematic review of the different categories of sepsis biomarkers including the new promising biomarkers and their role in diagnosis and prognosis of sepsis. Data sources Data were obtained from Medline databases (PubMed, Medscape, and Science Direct) and from materials available on the network from 2003 to April 2017. Study selection The initial search presented 30 articles. The research studies that met the inclusion criteria were 10 articles. All articles studied the role of biomarkers in diagnosis and prognosis of sepsis. Data extraction If the studies did not fulfill the inclusion criteria, they were excluded. Study quality …
Serum Polymorphonuclear Leukocyte Elastase Enzyme Level In Neonatal Sepsis, Ahmed T. Mahmoud, Dalia M. El-Lahouny, Khalid A. Khalifa, Mohamed R. Hosny
Serum Polymorphonuclear Leukocyte Elastase Enzyme Level In Neonatal Sepsis, Ahmed T. Mahmoud, Dalia M. El-Lahouny, Khalid A. Khalifa, Mohamed R. Hosny
Menoufia Medical Journal
Objective The aim of this study is to evaluate the clinical importance of polymorphonuclear leukocyte (PMN) elastase level in neonatal sepsis. Background Neonatal sepsis is defined as a clinical syndrome of bacteremia with systemic signs and symptoms of infection in the first 4 weeks of life. When pathogenic bacteria gain access into the bloodstream, they may cause overwhelming infection without much localization (septicemia) or may be predominantly localized to the lung (pneumonia) or the meninges. Patients and methods This prospective study was performed on 60 newborns, which included 30 newborns with positive clinical sepsis score and 30 healthy neonates matched …
Evaluation Of Hepcidin As A Biomarker For Neonatal Sepsis, Ahmed A. Khatab, Ahmed M. El Fishawy, Fadi M. Elgendy, Gehanabdel Fatah, Hassan S. Badr
Evaluation Of Hepcidin As A Biomarker For Neonatal Sepsis, Ahmed A. Khatab, Ahmed M. El Fishawy, Fadi M. Elgendy, Gehanabdel Fatah, Hassan S. Badr
Menoufia Medical Journal
Objective The aim of this study was to evaluate serum hepcidin as a biomarker for neonatal sepsis. Background Neonatal sepsis is one of the most important neonatal disorders frequently associated with high rate of mortality and morbidity. Hepcidin is the key iron regulator; the clear link between hepcidin and innate immunity may be used for detection of sepsis. Patients and methods This case–control study was carried out in the NICU of Menoufia University Hospital from April 2015 to October 2016. It was conducted on 60 neonates: 40 neonates admitted in NICU as they were suspected for neonatal sepsis based on …
Diagnostic Value Of Apolipoprotein A1 In Neonatal Sepsis, Dalia M. El-Lahony, Dina A. R. Midan, Fady M. El-Gendy, Wafaa M. Amin Shaban
Diagnostic Value Of Apolipoprotein A1 In Neonatal Sepsis, Dalia M. El-Lahony, Dina A. R. Midan, Fady M. El-Gendy, Wafaa M. Amin Shaban
Menoufia Medical Journal
Objective The aim of this study is to detect the value of apolipoprotein A1 (Apo A1) in the diagnosis and prognosis of neonatal sepsis in neonatal ICU of Menoufia University Hospitals. Background Neonatal sepsis is used to describe the inflammatory response to infection in neonates younger than 30 days of age. Apo A1 is the major protein component of high-density lipoprotein in plasma, which decreases during the inflammatory process. Patients and methods Our study was carried out on 60 neonates admitted to neonatal ICU of Menoufia University Hospitals from April 2015 to April 2016 and were divided into two groups: …
Stromal-Derived Factor-1 (Cxcl12) And Its Receptor (Cxcr4) In Neonatal Sepsis, Ahmed M. S. El-Hanafy, Fady M. El-Gendy, Hassan S. Badr, Mohamed A. Helwa
Stromal-Derived Factor-1 (Cxcl12) And Its Receptor (Cxcr4) In Neonatal Sepsis, Ahmed M. S. El-Hanafy, Fady M. El-Gendy, Hassan S. Badr, Mohamed A. Helwa
Menoufia Medical Journal
Background Neonatal sepsis remains a major cause of morbidity and mortality in newborns. The C-X-C motif chemokine 12 (CXCL12) and its receptor α-chemokine receptor type 4 (CXCR4) are now known to play an important role in inflammatory states and mediate lymphocyte migration in response inflammation. However, it is unclear how chemokines respond to late-onset neonatal sepsis (LOS). Objective The aim of this study was to assess the value of measuring the serum levels of stromal-derived factor-1, also named CXCL12, and lymphocyte expression levels of its receptor CXCR4 in the diagnosis of LOS in relation to clinical and hematological sepsis scores. …
Efficacy Of Early Goal-Directed Therapy In Severe Sepsis And Septic Shock, Enas Abd El-Mohsen Shaaheen, Khaled M. Abu El-Einein, Naglaa S. Abd El-Hady Hammad, Neveen I. Samy
Efficacy Of Early Goal-Directed Therapy In Severe Sepsis And Septic Shock, Enas Abd El-Mohsen Shaaheen, Khaled M. Abu El-Einein, Naglaa S. Abd El-Hady Hammad, Neveen I. Samy
Menoufia Medical Journal
Objective The aim of this review was to present the current trends and methodologies of the use of early goal-directed therapy (EGDT) and its efficacy in patients in severe sepsis and septic shock. Data sources Data were obtained from Medline databases (PubMed, Medscape, and Science Direct) and from materials available on the Internet from the start date of each database to February 2017. Data selection The selected articles are systematic reviews and experimental studies that address EGDT in severe sepsis and septic shock. Data extraction Extraction was performed according to the validity, quality, and originality of the selected reviews and …
Effectiveness Of Optimizing Lactate Clearance Versus Central Venous Oxygen Saturation As Target Goals Of Early Resuscitation In Sepsis, Enas Abdelmohsen, Hatem A. Atallah, Mohammad M. Torayah, Nagwa M. Doha
Effectiveness Of Optimizing Lactate Clearance Versus Central Venous Oxygen Saturation As Target Goals Of Early Resuscitation In Sepsis, Enas Abdelmohsen, Hatem A. Atallah, Mohammad M. Torayah, Nagwa M. Doha
Menoufia Medical Journal
Objective The aim of this study was to compare the effect of optimizing lactate clearance versus central venous oxygen saturation (ScvO2) as target goals in early sepsis resuscitation. Background Optimal goals for quantitative sepsis resuscitation remain uncertain. It is accepted that hemodynamic targets should include a measure of cardiac preload, such as central venous pressure (CVP), and perfusion pressure, such as mean arterial pressure (MAP). A more controversial issue is the method of determining oxygen delivery. Lactate clearance potentially represents a more accessible method to assess tissue oxygen delivery. Patients and methods We conducted a randomized prospective observational …