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Increased Brain White Matter Axial Diffusivity Associated With Fatigue, Pain And Hyperalgesia In Gulf War Illness, Rakib U. Rayhan, Benson W. Stevens, Christian R. Timbol, Oluwatoyin Adewuyi, Brian Walitt, John Vanmeter, James N. Baraniuk
Increased Brain White Matter Axial Diffusivity Associated With Fatigue, Pain And Hyperalgesia In Gulf War Illness, Rakib U. Rayhan, Benson W. Stevens, Christian R. Timbol, Oluwatoyin Adewuyi, Brian Walitt, John Vanmeter, James N. Baraniuk
Medicine Faculty Publications
Background
Gulf War exposures in 1990 and 1991 have caused 25% to 30% of deployed personnel to develop a syndrome of chronic fatigue, pain, hyperalgesia, cognitive and affective dysfunction.
Methods
Gulf War veterans (n = 31) and sedentary veteran and civilian controls (n = 20) completed fMRI scans for diffusion tensor imaging. A combination of dolorimetry, subjective reports of pain and fatigue were correlated to white matter diffusivity properties to identify tracts associated with symptom constructs.
Results
Gulf War Illness subjects had significantly correlated fatigue, pain, hyperalgesia, and increased axial diffusivity in the right inferior fronto-occipital fasciculus. ROC …