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Genomic Profiling Reveals The Potential Role Of Tcl1a And Mdr1 Deficiency In Chemotherapy-Induced Cardiotoxicity, Timothy A. Mccaffrey, Constantine Tziros, Jannet Lewis, Richard Katz, Robert S. Siegel, William B. Weglicki, Jay H. Kramer, I. Tong Mak, Ian Toma, Liang Chen, Elizabeth Benas, Alexander Lowitt, Shruti Rao, Linda Witkin, Yi Lian, Zhaoqing Yang, Sidney W. Fu
Genomic Profiling Reveals The Potential Role Of Tcl1a And Mdr1 Deficiency In Chemotherapy-Induced Cardiotoxicity, Timothy A. Mccaffrey, Constantine Tziros, Jannet Lewis, Richard Katz, Robert S. Siegel, William B. Weglicki, Jay H. Kramer, I. Tong Mak, Ian Toma, Liang Chen, Elizabeth Benas, Alexander Lowitt, Shruti Rao, Linda Witkin, Yi Lian, Zhaoqing Yang, Sidney W. Fu
Medicine Faculty Publications
Background: Anthracyclines, such as doxorubicin (Adriamycin), are highly effective chemotherapeutic agents, but are well known to cause myocardial dysfunction and life-threatening congestive heart failure (CHF) in some patients.
Methods: To generate new hypotheses about its etiology, genome-wide transcript analysis was performed on whole blood RNA from women that received doxorubicin-based chemotherapy and either did, or did not develop CHF, as defined by ejection fractions (EF)≤40%. Women with non-ischemic cardiomyopathy unrelated to chemotherapy were compared to breast cancer patients prior to chemo with normal EF to identify heart failure-related transcripts in women not receiving chemotherapy. Byproducts of oxidative stress in plasma …