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Full-Text Articles in Medicine and Health Sciences
Impact Of Single Nucleotide Polymorphisms On Hpa Axis Functionality In Depression, Claire Kelly
Impact Of Single Nucleotide Polymorphisms On Hpa Axis Functionality In Depression, Claire Kelly
Honors Theses
The hypothalamic-pituitary-adrenal (HPA) axis plays a primary role in stress response through the regulated secretion of the glucocorticoid hormone cortisol. Diseases of cortisol dysregulation such as Cushing’s syndrome (hypercortisolemia) and Addison’s Disease (hypocortisolemia) are both associated with depression. Based on this we, and others, have hypothesized that mutations in the genes for the glucocorticoid receptor (GR), the closely related mineralocorticoid receptor (MR), and regulatory proteins associated with cortisol or GR function may contribute to depression in the absence of hyper- or hypo-cortisolemia. Our study investigated the genotypic frequency in the clinical population of several single nucleotide polymorphisms (SNPs) that affect …
Assessing Glucocorticoid Receptor Polymorphisms In Obese Populations, Ayanah Dowdye
Assessing Glucocorticoid Receptor Polymorphisms In Obese Populations, Ayanah Dowdye
Honors Theses
The glucocorticoid receptor (GR) is part of a family of nuclear receptors that control gene expression. In the presence of the steroid hormone cortisol, certain genes are expressed; the products of which control certain features of the body, including but not limited to, blood pressure, serum triglycerides, and blood sugar. There is evidence that these features are major contributors to obesity. Specific polymorphisms of the GR and other regulators of either GR or the closely related mineralocorticoid receptor such as heat shock protein 90 and 11ß-hydroxysteroid dehydrogenase type 1 have been found in our labs and others to be present …