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Full-Text Articles in Medicine and Health Sciences
Cannabinoid Modulation Of Microglial Activation In Multiple Sclerosis, Natalie Shea Lemons
Cannabinoid Modulation Of Microglial Activation In Multiple Sclerosis, Natalie Shea Lemons
Honors Theses
Multiple Sclerosis (MS) is a neurodegenerative disease that is estimated to affect 400,000 Americans. There is no cure for MS and some treatments at this point are toxic to patients. Dr. Lori Hensley's lab is researching two drugs that could potentially be used to treat MS without toxic effects. Previous work in the lab shows ajulemic acid, a synthetic molecule similar to metabolites from the cannabis plant, selectively suppresses markers of the inflammatory response. worked on the mechanism of ajulemic acid's action by investigating the roles of several candidate receptors in mediating these observed effects.
Resveratrol Modulation Of Microglial Activation And Provision For Neuroprotection In Multiple Sclerosis, Joseph L. Green
Resveratrol Modulation Of Microglial Activation And Provision For Neuroprotection In Multiple Sclerosis, Joseph L. Green
Honors Theses
Multiple sclerosis (MS) is an autoimmune disease affecting over 2.5 million people worldwide. In MS, myelin sheaths surrounding the axons of neurons are attacked by the immune system, leading to many deleterious symptoms. No cure for MS has been found, but some treatments reducing the number of exacerbations are available. Studies on resveratrol show the compound to have anti-inflammatory properties that could be beneficial in the treatment of diseases like MS. In our research, we used a cellular model to imitate neurons of the central nervous system and tested the effects of resveratrol in the hope of finding neuroprotective properties.