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Comparison Of The Performance Of Two Different Alk Antibody Clones (D5f3 And Alk1) In Anaplastic Large Cell Lymphoma (Alcl), Dana Martin, Steven Smith, Alden Chesney, Terra Lewis, Raghavendra Pillappa
Comparison Of The Performance Of Two Different Alk Antibody Clones (D5f3 And Alk1) In Anaplastic Large Cell Lymphoma (Alcl), Dana Martin, Steven Smith, Alden Chesney, Terra Lewis, Raghavendra Pillappa
Graduate Medical Education (GME) Resident and Fellow Research Day Posters
Background:Anaplastic large cell lymphoma (ALCL) is a T-cell lymphoma characterized by CD30 expression and subdivided into anaplastic lymphoma kinase (ALK) positive and negative subtypes that show clinically significant differences in outcomes. The current standard for evaluating ALK status is immunohistochemistry using the mouse monoclonal anti-human CD246 (ALK1) or fluorescence in situ hybridization. The novel rabbit monoclonal anti-human CD246 (D5F3) is proposed as an alternative to ALK1 and FDA approved for diagnosis of ALK-rearranged lung adenocarcinoma. However, its performance has not been systematically tested and compared to ALK1 in ALCL.
Design: Twenty-seven cases of ALCL were identified from institutional database searches …