Medicine and Health Sciences Commons^™

Bringing An Evidence-Based Nutrition And Exercise Lifestyle Intervention Program (Nelip) For Obese Pregnant Women Into Clinical Practice, Samantha Langstaff

Electronic Thesis and Dissertation Repository

One purpose was to identify the need for specialized care (My Clinic) for women with a pre-pregnancy body mass index (BMI) of ≥ 35 kg/m^2.. Women receiving My Clinic care were compared to a matched cohort control group (perinatal database, N=47). My Clinic care significantly reduced rates of macrosomia (5% vs 28%, p=0.02) and small birth weight babies (0% vs 6%, p=0.00) compared to perinatal database.

The second purpose was to test the efficacy of a Nutrition and Exercise Lifestyle Intervention Program (NELIP) in this clinical setting to prevent excessive weight gain, macrosmia, small birth weight …

Inhibition Of Elongation Factor 1a-1 Activity And Hepatic Lipotoxicity, Alexandra Margaret Anne Hetherington

Electronic Thesis and Dissertation Repository

Elongation factor 1A-1 (eEF1A-1) was previously identified as a mediator of fatty acid-induced cell death (lipotoxicity) downstream of endoplasmic reticulum (ER) stress. Furthermore, inhibition of the peptide elongation activity of eEF1A-1 with the cyclic depsipeptide didemnin B (DB) diminishes ER stress and lipotoxicity in cultured hepatocytes. Since ER stress is involved in nonalcoholic fatty liver disease (NAFLD), it was hypothesized that administration of DB to obese mice with NAFLD would reduce hepatic lipotoxicity. Treatment with DB for one week improved several parameters associated with hepatic lipotoxicity and modestly decreased food intake without evidence of illness. Liver triglycerides and protein markers …