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Towards Stem Cell Treatment For Duchenne Muscular Dystrophy-Related Cardiomyopathy, Bogdan A. Bondoc
Towards Stem Cell Treatment For Duchenne Muscular Dystrophy-Related Cardiomyopathy, Bogdan A. Bondoc
Electronic Thesis and Dissertation Repository
Duchenne muscular dystrophy (DMD) is a progressive muscular degenerative disease affecting 1 in 3,500 boys. Cardiomyopathy is observed in 95% of patients aged 18 and older, accounting for 30% of deaths. While innovative treatments have been employed to curb symptoms in skeletal muscle, few show success in the heart, and no cure for DMD exists. Recently, regenerative therapy using cardiac stem cells (CSCs) has shown very promising results, but efficacy in DMD remains undetermined. This dissertation sought to provide preliminary insight into the effects of murine Sca-1+ CSC therapy. Three-dimensional echocardiography was validated and used to gauge cardiomyopathy in …
Quality Of Life And Health-Related Quality Of Life In Children With Duchenne Muscular Dystrophy, Yi Wei
Quality Of Life And Health-Related Quality Of Life In Children With Duchenne Muscular Dystrophy, Yi Wei
Electronic Thesis and Dissertation Repository
Quality of life studies in Duchenne Muscular Dystrophy are scarce. This study explores the relationship between the broad concept of quality of life and the more focused concept of health-related quality of life and examines the relationships between patient and family characteristics and health-related quality of life. Participants were recruited from the Canadian Neuromuscular Disease Registry, 98 parents and 85 children completed the Quality of My Life and Pediatric Quality of Life Inventory questionnaires. Simple regression was used to examine the relationship between quality of life and health-related quality of life. Multivariable linear regressions were used to determine child and …