Medicine and Health Sciences Commons^™

Exploring A Multifactorial, Clinical Model Of Thought Disorder : Application Of A Dimensional, Transdiagnostic Approach., Mara Ann Hart

Electronic Theses and Dissertations

Background: Bleuler saw thought disorder as the core defining feature of psychotic phenomena, reflective of the “splitting of the psychic functions” that occurred when, in the process of thinking, one’s ideas and feelings disconnect, becoming fragmented and competing functions. Unfortunately, interest in thought disorder as the conceptual core of psychosis was lost with rise of the modern DSM system, paralleling the shift towards a more simplistic, categorical way of defining psychiatric disorders. Aims: This study examined thought disorder from a dimensional perspective, with the aim of disentangling qualitative heterogeneity and diverse sources of influence. Analyses were based on …

An Analysis Of Neurogenesis In A Mouse Model Of Chemotherapy Related Cognitive Impairment, Maxwell A. Hennings

Electronic Theses and Dissertations

Cancer patients treated with adjuvant chemotherapy often experience cognitive decline following treatment. This phenomenon, often dubbed “chemo brain” or “chemo fog” is usually temporary, but for a subset of survivors, these cognitive impairments can be long-lasting (>10 years) and negatively affect patients’ quality of life, career performance, and social fulfillment. While it is unclear what neurobiological mechanisms underlie chemotherapy related cognitive impairment, the majority of the animal literature has focused on adult neurogenesis. One process important for neurogenesis is the proliferation of new neurons within the dentate gyrus of the hippocampus. It is evident that many chemotherapy agents can …

Phenomenological Study Of The Lived Experiences Of Appalachian Spouses Of Combat Veterans With Post Traumatic Stress Disorder, Janice E. Greene

Electronic Theses and Dissertations

This study was conducted to identify gaps in existing knowledge regarding impacts of combat-related PTSD on the spouse and to gain an understanding of the lived experience of Appalachian Spouses of combat veterans with PTSD. A systematic literature review was conducted to identify research and findings on the impacts of combat-related PTSD on spouses of veterans and a qualitative study was conducted to gain an understanding of the lives of Appalachian spouses of combat veterans with PTSD.

The systematic review identified 16 qualitative studies conducted between 1988 and 2016 in five countries spanning five wars. Regardless of the country of …

A Systems Approach To Moral Distress In Long Term Care, Margaret Lemley

Electronic Theses and Dissertations

Abstract: The question that this dissertation seeks to answer is whether or not a Systems Approach to Moral Distress can serve to positively address issues of moral distress within the Long-Term Care setting. Because moral distress has largely been understood as a phenomenon of the individual, efforts to address and reduce incidents of moral distress have focused almost entirely on the individual and his or her reaction to specific triggers. Building upon the existing literature this dissertation argues that previous efforts to understand moral distress within the healthcare setting have been limiting in two very important aspects. The first …

Preclinical Assessment Of Immunocal® As A Preventative Treatment For Traumatic Brain Injury (Tbi) In A Mouse Model Of Closed Head Injury, Elizabeth Eugenia Ignowski

Electronic Theses and Dissertations

Over the past three decades, traumatic brain injury (TBI) has been considered a "silent epidemic" and recognized as an emergent public health problem by the Centers for Disease Control and Prevention (CDC). TBI is defined as a bump, blow, or jolt to the head that disrupts the normal function of the brain. Due to the debilitating effects and prevalence of TBI, novel preventative treatment regimens are highly desirable in at risk populations. According to the CDC groups disproportionately affected by TBI include athletes, people aged 75+, and service men and women, among others. Here, we investigated a unique whey protein …

Phylogeny, Psychology, And The Vicissitudes Of Human Development: The Anxiety Of Atavism, Frank Pittenger

Electronic Theses and Dissertations

This cross-disciplinary dissertation provides a missing intellectual history of an ostensibly dead idea. Once widely held and no less elegant for its obsolescence, the principle of biogenetic recapitulation is best remembered by its defining mantra, “ontogeny recapitulates phylogeny.” Among psychologists and sociologists as well as embryologists, the notion that the development of any individual organism repeats in compressed, miniaturized form the entire history of its species enjoyed broad (if not uncontested) acceptance through the early twentieth century. The author reexamines the origins of this theory in the work of Charles Darwin and Ernst Haeckel, and traces its influence in psychology …

Differential Modulation Of Oxycodone Reward And Analgesia By A Cannabinoid Derivative, Hannah Marie Harris

Electronic Theses and Dissertations

No abstract provided.

Treatment Choice Among Combat Veterans, Zachary Clayborne Dietrich

Electronic Theses and Dissertations

A plethora of research has investigated PTSD treatment outcomes among Veterans of foreign wars. However, research has suggested mixed treatment efficacy. Although investigations into factors that may help predict treatment outcomes are emerging, to date no study has evaluated treatment choice among Veteran populations. Previous treatment choice studies have yielded qualitative and quantitative information that can be useful in clinical decision-making. This study looks to build upon the treatment choice literature with combat Veterans to evaluate for underlining characteristics of cohorts that will help build upon existing knowledge. It has been suggested that treatment benefits Vietnam Era Veterans more than …