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Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Anxiety In Children With Williams Syndrome : Association With Negative Reactivity, Self-Regulation, And Sensory Modulation., Nicole A. Crawford-Zelli
Anxiety In Children With Williams Syndrome : Association With Negative Reactivity, Self-Regulation, And Sensory Modulation., Nicole A. Crawford-Zelli
Electronic Theses and Dissertations
Williams syndrome (WS) is a neurodevelopmental disorder caused by a submicroscopic deletion of approximately 25 genes on chromosome 7q11.23 (Hillier et al., 2003). This genotype is associated with a characteristic set of phenotypic features including mild to moderate intellectual disability, a distinctive cognitive profile, facial dysmorphology, common personality traits, cardiovascular problems, and connective tissue disorders (Morris, 2010). In addition, behavioral difficulties such as anxiety symptoms (e.g., Leyfer, Woodruff-Borden, & Mervis, 2009), negative reactivity (e.g., Davies, Udwin, & Howlin, 1998), problems with self-regulation (e.g., Woodruff-Borden, Kistler, Henderson, Crawford, & Mervis, 2010), and sensory modulation difficulties (e.g., John & Mervis, 2010) are …
Cyclin E Induction And Oncolytic Replication Of E1b-Deleted Adenoviruses., Pei-Hsin Cheng
Cyclin E Induction And Oncolytic Replication Of E1b-Deleted Adenoviruses., Pei-Hsin Cheng
Electronic Theses and Dissertations
Virus-mediated oncolysis has been considered as a new and promising cancer therapeutic approach. Although adenoviruses (Ads) with deletion of E1b55K preferentially replicate in cancer cells and have been used in numerous cancer treatments, the selective replication mechanism of this kind of virus still remains controversial. The lack of a well-established studies focusing on possible mechanisms enabling tumor selectivity of oncolytic Ads has hindered the further development of virotherapies and limits their clinical applications. Therefore, uncovering the molecular basis behind the tumor-killing phenomena will fill critical gaps in our understanding of the oncolytic adenovirology. Previously our laboratory has demonstrated that Ad …
Patient Preference And Compliance Between Hawley Retainers And Vacuum-Formed Retainers Following Orthodontic Treatment., Justin Wild
Electronic Theses and Dissertations
Introduction: The traditional Hawley retainer has been replaced in many orthodontic offices by vacuum-formed retainers (VFRs). There has yet to be a study that investigates preferences and reasons for noncompliance between Hawley and vacuum-formed retainers by allowing each to be worn within the same patient. Specific Aim: To determine differences in compliance and reasons for noncompliance between Hawley and VFRs. Hypothesis: There will be increased compliance with VFRs due to better esthetics, speech, and comfort. Methods: In consecutive months but in a different order, two treatment groups received a set of Hawleys and VFRs following comprehensive treatment. All patients were …
The Involvement Of Beta-Catenin In The Inflammatory Response Leading To Autoimmune Diabetes Development., Arin Lee Zirnheld
The Involvement Of Beta-Catenin In The Inflammatory Response Leading To Autoimmune Diabetes Development., Arin Lee Zirnheld
Electronic Theses and Dissertations
We identified and characterized a novel defect in β-catenin expression in bone marrow derived dendritic cells (BMDC) from NOD mice, a model for human Type I diabetes. This protein is expressed at high levels throughout the lifespan of the mouse and correlates with increased pro-inflammatory cytokine production by the BMDC and IFNγ induction by T cells cocultured with the BMDC. These defects, including a similar pattern of pro-inflammatory cytokine production, are also observed in human monocytederived DC from diabetic patients. After exploring several potential mechanisms involved in the accumulation of β-catenin in NOD BMDC, we found that β-catenin is phosphorylated …
Influential Variables On The Timing Of Help-Seeking Behavior In Lung Cancer Patients., Lisa Carter-Harris
Influential Variables On The Timing Of Help-Seeking Behavior In Lung Cancer Patients., Lisa Carter-Harris
Electronic Theses and Dissertations
Lung cancer kills more people than any other cancer worldwide primarily because it is often diagnosed at an advanced stage. One factor that can influence advanced stage lung cancer diagnosis is delayed help-seeking behavior in individuals with symptoms suggestive of lung cancer. Delayed help-seeking behavior has been investigated in acute cardiovascular events and breast cancer, but there is little evidence on specific factors that influence the timing of help-seeking behavior in lung cancer patients. The purpose of this study was to explore the influence of healthcare system distrust, lung cancer stigma, and smoking status on the timing of help-seeking behavior …
Cardiovascular Disease Among Diabetic Women With Bilateral Oophorectomy., Duke Appiah
Cardiovascular Disease Among Diabetic Women With Bilateral Oophorectomy., Duke Appiah
Electronic Theses and Dissertations
Cardiovascular Disease (CVD) is the leading cause of death in women and the risk is increased threefold in diabetics. In postmenopausal diabetics, the ovary responds to hyperinsulinemia by increasing secretion of testosterone precursors which increases the risk of CVD. Data from the National Health and Nutrition Examination Survey (1988-2010) and the Study of Osteoporotic Fractures were used to test the hypothesis that a history of bilateral oophorectomy -surgical removal of both ovaries-would decrease the risk of CVD among postmenopausal diabetic women due to reduced androgen levels. Logistic regression, discrete time logit model, B-Spline regression and Cox proportional hazards models were …
Role Of Ethanol As A Cofactor In Haart Induced Hepatic Steatosis And Injury., Hridgandh Donde
Role Of Ethanol As A Cofactor In Haart Induced Hepatic Steatosis And Injury., Hridgandh Donde
Electronic Theses and Dissertations
Highly Active Antiretroviral Therapy (HAART) has led to a significant increase in the life expectancy of HIV patients; however, there are significant side effects including lipodystrophy and hepatotoxicity. Alcohol abuse is highly prevalent in HIV infected individuals and hence may be a significant negative cofactor in HAART induced hepatotoxicity. The present study examines the mechanisms underlying HAART and alcohol induced hepatotoxicity. The effects of HAART drugs (azidothymidine, and Indinavir sulphate) in combination with alcohol were examined in in vivo animal model. Alcohol and HAART drug interactions and hepatotoxicity were also assessed in-vivo using an animal model of chronic alcohol feeding. …