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Full-Text Articles in Medicine and Health Sciences
Development And Characterization Of Sustained-Release Formulations Via Novel Hot Melt Extrusion Techniques, Bjad Khalaf Almutairy
Development And Characterization Of Sustained-Release Formulations Via Novel Hot Melt Extrusion Techniques, Bjad Khalaf Almutairy
Electronic Theses and Dissertations
Hot melt extrusion (HME) is a leading technology that can be applied to many pharmaceutical preparations as solid dispersions. Part of this research project focus on injecting pressurized carbon dioxide (P-CO2) gas during the HME process. These combined techniques have an additional advantage of being adaptable and portable to a hot melt extruder instrument. The use of HME alongside with other techniques (P-CO2 or co extrusion process) for preparing an improved controlled/sustained release formulation is the main theme of this research project. Current research focusing on Active Pharmaceutical Ingredients (APIs) with good aqueous solubility requires novel approach to obtain tailored …
Hot-Melt Extrusion: A Versatile Pharmaceutical Technology, Hemlata Patil
Hot-Melt Extrusion: A Versatile Pharmaceutical Technology, Hemlata Patil
Electronic Theses and Dissertations
Hot-melt extrusion (HME) is a promising technology for the production of new chemical entities in the developmental pipeline and for improving products already on the market. The first objective of this research work was to describe a continuous process for the production of solid lipid nanoparticles (SLN) as drug-carrier systems via hot-melt extrusion (HME) using Quality by Design (QbD) principles. Fenofibrate SLN were prepared by combining two processes: HME technology for melt-emulsification and high-pressure homogenization (HPH) for size reduction. Varying the process parameters enabled the production of SLN below 200 nm. At the end of a 5-h in-vitro dissolution study, …
Solubility Enhancement Via Melt Extrusion: Drug-Polymer Solubility, Physicochemical Characterization And Quality By Design, Ketaki Patwardhan
Solubility Enhancement Via Melt Extrusion: Drug-Polymer Solubility, Physicochemical Characterization And Quality By Design, Ketaki Patwardhan
Electronic Theses and Dissertations
Many new drugs developed face oral delivery challenges and absorption due to poor biopharmaceutical properties. Formation of solid dispersions is a very widely applied technique for solubility enhancement of water insoluble drugs. In order to form stable solid dispersions it is important to select appropriate excipients that will maintain the drug in its amorphous form for an extended period of time. Selection of appropriate excipients is critical during the development of stable amorphous solid dispersions. The solubility parameter concept has been explored for theoretically identifying the excipients that will be suitable based on the structure of the active. In this …
Preparation And Characterization Of Lyophilized Cyclodextrin Complexes Of A Hemisuccinate Ester Of Delta-9-Tetrahydrocannabinol For Transmucosal Delivery, Sampada Bhaskar Upadhye
Preparation And Characterization Of Lyophilized Cyclodextrin Complexes Of A Hemisuccinate Ester Of Delta-9-Tetrahydrocannabinol For Transmucosal Delivery, Sampada Bhaskar Upadhye
Electronic Theses and Dissertations
Delta-9- Tetrahydrocannabinol (THC) is the primary active ingredient of the plant Cannabis sativa (marijuana), responsible for the majority of the pharmacological effects. The most promising clinical applications of THC approved by the Food and Drug Administration (FDA) are for the control of nausea and vomiting associated with chemotherapy and for appetite stimulation of AIDS patients suffering from anorexia and wasting syndrome. The only dosage form currently approved by FDA is an oral, soft gelatin capsule (e.g. Marinol®). In addition, orally administered THC from Marinol® has shown slow and variable absorption due to low oral solubility and first pass metabolism. Our …