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Department of Medicine Publications

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Memory

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Full-Text Articles in Medicine and Health Sciences

Increased Top-Down Control Of Emotions During Symptom Provocation Working Memory Tasks Following A Rct Of Alpha-Down Neurofeedback In Ptsd., Saurabh Bhaskar Shaw, Andrew A Nicholson, Tomas Ros, Sherain Harricharan, Braeden Terpou, Maria Densmore, Jean Theberge, Paul Frewen, Ruth A Lanius Jan 2023

Increased Top-Down Control Of Emotions During Symptom Provocation Working Memory Tasks Following A Rct Of Alpha-Down Neurofeedback In Ptsd., Saurabh Bhaskar Shaw, Andrew A Nicholson, Tomas Ros, Sherain Harricharan, Braeden Terpou, Maria Densmore, Jean Theberge, Paul Frewen, Ruth A Lanius

Department of Medicine Publications

BACKGROUND: Posttraumatic stress disorder (PTSD) has been found to be associated with emotion under-modulation from the prefrontal cortex and a breakdown of the top-down control of cognition and emotion. Novel adjunct therapies such as neurofeedback (NFB) have been shown to normalize aberrant neural circuits that underlie PTSD psychopathology at rest. However, little evidence exists for NFB-linked neural improvements under emotionally relevant cognitive load. The current study sought to address this gap by examining the effects of alpha-down NFB in the context of an emotional n-back task.

METHODS: We conducted a 20-week double-blind randomized, sham-controlled trial of alpha-down NFB and collected …


How The Body Remembers: Examining The Default Mode And Sensorimotor Networks During Moral Injury Autobiographical Memory Retrieval In Ptsd., Breanne E Kearney, Braeden A Terpou, Maria Densmore, Saurabh B Shaw, Jean Theberge, Rakesh Jetly, Margaret C Mckinnon, Ruth A Lanius Jan 2023

How The Body Remembers: Examining The Default Mode And Sensorimotor Networks During Moral Injury Autobiographical Memory Retrieval In Ptsd., Breanne E Kearney, Braeden A Terpou, Maria Densmore, Saurabh B Shaw, Jean Theberge, Rakesh Jetly, Margaret C Mckinnon, Ruth A Lanius

Department of Medicine Publications

Neural representations of sensory percepts and motor responses constitute key elements of autobiographical memory. However, these representations may remain as unintegrated sensory and motor fragments in traumatic memory, thus contributing toward re-experiencing and reliving symptoms in trauma-related conditions such as post-traumatic stress disorder (PTSD). Here, we investigated the sensorimotor network (SMN) and posterior default mode network (pDMN) using a group independent component analysis (ICA) by examining their functional connectivity during a script-driven memory retrieval paradigm of (potentially) morally injurious events in individuals with PTSD and healthy controls. Moral injury (MI), where an individual acts or fails to act in a …