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Full-Text Articles in Medicine and Health Sciences

Genome-Wide Dna Methylation Meta-Analysis In The Brains Of Suicide Completers, Stefanie Policicchio, Sam Washer, Joana Viana, Artemis Latrou, Joe Burrage, Eilis Hannon, Gustavo Turecki, Zachary Kaminsky, Jonathan Mill, Emma L. Dempster, Therese Murphy Feb 2020

Genome-Wide Dna Methylation Meta-Analysis In The Brains Of Suicide Completers, Stefanie Policicchio, Sam Washer, Joana Viana, Artemis Latrou, Joe Burrage, Eilis Hannon, Gustavo Turecki, Zachary Kaminsky, Jonathan Mill, Emma L. Dempster, Therese Murphy

Articles

Suicide is the second leading cause of death globally among young people representing a significant global health burden. Although the molecular correlates of suicide remains poorly understood, it has been hypothesised that epigenomic processes may play a role. The objective of this study was to identify suicide-associated DNA methylation changes in the human brain by utilising previously published and unpublished methylomic datasets. We analysed prefrontal cortex (PFC, n = 211) and cerebellum (CER, n = 114) DNA methylation profiles from suicide completers and non-psychiatric, sudden-death controls, meta-analysing data from independent cohorts for each brain region separately. We report evidence for …


Genome-Wide Dna Methylation Meta-Analysis In The Brains Of Suicide Completers, Stefania Policicchio, Sam Washer, Joana Viana, Artemis Iatrou, Joe Burrage, Eilis Hannon, Gustavo Tureki, Zachary Kaminsky, Jonathan Mill, Emma L. Dempster, Therese Murphy Jan 2020

Genome-Wide Dna Methylation Meta-Analysis In The Brains Of Suicide Completers, Stefania Policicchio, Sam Washer, Joana Viana, Artemis Iatrou, Joe Burrage, Eilis Hannon, Gustavo Tureki, Zachary Kaminsky, Jonathan Mill, Emma L. Dempster, Therese Murphy

Articles

Suicide is the second leading cause of death globally among young people representing a significant global health burden. Although the molecular correlates of suicide remains poorly understood, it has been hypothesised that epigenomic processes may play a role. The objective of this study was to identify suicide-associated DNA methylation changes in the human brain by utilising previously published and unpublished methylomic datasets. We analysed prefrontal cortex (PFC, n = 211) and cerebellum (CER, n = 114) DNA methylation profiles from suicide completers and non-psychiatric, sudden-death controls, meta-analysing data from independent cohorts for each brain region separately. We report evidence for …


A History Of The Law Of Assisted Dying In The United States, Alan Meisel Jan 2020

A History Of The Law Of Assisted Dying In The United States, Alan Meisel

Articles

The slow growth in the number of states that have enacted legislation to permit what is often referred to as “death with dignity” legislation—and more frequently referred to popularly as “physician assisted suicide” laws—has begun to accelerate in the past few years since the enactment of the first such statute in Oregon in 1994.

Like much other social reform legislation, there is a long history behind it. In this case, the history in the United States dates back at least to the latter part of the nineteenth century. Not until the 1980s, however, did these efforts gain any traction in …