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Full-Text Articles in Medicine and Health Sciences
Preoperative Exercise To Improve Fitness In Patients Undergoing Complex Surgery For Cancer Of The Lung Or Oesophagus (Pre-Hiit): Protocol For A Randomized Controlled Trial, Grainne Sheill, Emer Guinan, Linda O'Neill, Charles Normand, Suzanne Doyle, Sarah Moore, John Newell, Granne Mcdermott, Ronan Ryan, John V. Reynolds, Juliette Hussey
Preoperative Exercise To Improve Fitness In Patients Undergoing Complex Surgery For Cancer Of The Lung Or Oesophagus (Pre-Hiit): Protocol For A Randomized Controlled Trial, Grainne Sheill, Emer Guinan, Linda O'Neill, Charles Normand, Suzanne Doyle, Sarah Moore, John Newell, Granne Mcdermott, Ronan Ryan, John V. Reynolds, Juliette Hussey
Articles
Patients with cancer of the lung or oesophagus, undergoing curative treatment, usually require a thoracotomy and a complex oncological resection. These surgeries carry a risk of major morbidity and mortality, and risk assessment, preoperative optimisation, and enhanced recovery after surgery (ERAS) pathways are modern approaches to optimise outcomes. Pre-operative fitness is an established predictor of postoperative outcome, accordingly, targeting pre-operative fitness through exercise prehabilitation has logical appeal. Exercise prehabilitation is challenging to implement however due to the short opportunity for intervention between diagnosis and surgery. Therefore, individually prescribed, intensive exercise training protocols which convey clinically meaningful improvements in cardiopulmonary fitness …
High Lymph Node Positive To Sampled Ratio As A Potential Indication For Postoperative Radiation Therapy In Patients With Pn2 Non-Small-Cell Lung Cancer, Nikhil P Mankuzhy, Muayad F Almahariq, Craig W Stevens, Thomas J Quinn
High Lymph Node Positive To Sampled Ratio As A Potential Indication For Postoperative Radiation Therapy In Patients With Pn2 Non-Small-Cell Lung Cancer, Nikhil P Mankuzhy, Muayad F Almahariq, Craig W Stevens, Thomas J Quinn
Articles
Background: The role for postoperative radiation therapy (PORT) for patients with non–small-cell lung cancer (NSCLC) with mediastinal lymph node (LN) involvement (pN2 disease) is controversial. We performed a SEER analysis comparing surgery alone with PORT among patients with pN2 NSCLC. As we await the final results of the LUNG ART trial, a subset of patients with a high LN positive to sampled (LPR) ratio may benefit from PORT. Patients/methods: Patients with pN2 NSCLC, ranging from 1989-2016, were assessed from the Surveillance, Epidemiology and End Results (SEER) database. A propensity score (PS)-matched, inverse probability of treatment weighting (IPTW) analysis was conducted …