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Yale University

Theses/Dissertations

2009

Animal Model

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The Role Of Frizzled-1 And Frizzled-3 In Olfactory Sensory Neuronal Targeting, Mina Safain Jan 2009

The Role Of Frizzled-1 And Frizzled-3 In Olfactory Sensory Neuronal Targeting, Mina Safain

Yale Medicine Thesis Digital Library

THE ROLE OF FRIZZLED-1 AND FRIZZLED-3 IN OLFACTORY SENSORY NEURONAL TARGETING. Mina G. Safain. Department of Neurosurgery, Yale University School of Medicine, New Haven, CT. While most areas of the brain do not exhibit profound neurogenesis or continuing synaptogenesis in the adult, there are notable exceptions which include the olfactory and hippocampal regions of the nervous system. In the olfactory system the olfactory sensory neurons continually turn over and extend their axons into the olfactory bulb in a highly precise manner. Some preliminary data exists that suggests the presence of Wnt and Frizzled (Fz) family members in the primary olfactory …