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Articles 1 - 16 of 16
Full-Text Articles in Medicine and Health Sciences
Gene Modification With Triplex-Forming Oligonucleotides, Jennifer Melissa Kalish
Gene Modification With Triplex-Forming Oligonucleotides, Jennifer Melissa Kalish
Yale Medicine Thesis Digital Library
No abstract provided.
B Cells At The Interface Of Innate And Adaptive Immunity In Systemic Lupus Erythematosus: Requirements For The Activation Of Autoreactive B Cells In Autoimmune Disease, Sean Ryan Christensen
B Cells At The Interface Of Innate And Adaptive Immunity In Systemic Lupus Erythematosus: Requirements For The Activation Of Autoreactive B Cells In Autoimmune Disease, Sean Ryan Christensen
Yale Medicine Thesis Digital Library
Systemic autoimmune disease is characterized by loss of immunologic tolerance to a restricted set of self-nuclear antigens. These macromolecular complexes can be grouped into two categories: DNA-containing autoantigens such as chromatin, and RNA containing autoantigens such as Smith antigen (Sm) and related ribonucleoprotein complexes. Elucidating the mechanism for selective targeting of these molecules in systemic lupus erythematosus (SLE) may provide clues to the etiology of disease. We hypothesized that Toll-like receptors (TLRs), germline-encoded pattern-recognition receptors of the innate immune system, could dictate target antigen specificity in SLE. Using genetic ablation of various TLRs in murine models of SLE, we have …
Molecular Classification And Prediction Of Metastatic Potential In Early Malignant Melanoma: Improvement Of Prognostic Accuracy By Quantitative In Situ Proteomic Analysis, Aaron J. Berger
Yale Medicine Thesis Digital Library
The incidence of cutaneous malignant melanoma continues to increase every year, and remains the leading cause of skin cancer death in industrialized countries. In spite of the aggressive nature of advanced melanoma, there are no standard biological assays in clinical usage that can predict metastasis. This may be due, in part, to the inadequacy of reproducible assessment of protein expression using traditional immunohistochemistry. This dissertation will discuss the use of tissue microarrays combined with quantitative in situ molecular analysis of protein expression to allow prediction of melanoma metastasis. Through the identification and validation of novel prognostic biomarkers, we seek to …
Pathogenocide : Infectious Disease And The Intent To Destroy, Kristy M. Layton
Pathogenocide : Infectious Disease And The Intent To Destroy, Kristy M. Layton
Yale Medicine Thesis Digital Library
No abstract provided.
T Cell Integrin Dependent, Mkk3/P38 Mapk-Mediated Stabilization Of Labile Cytokine Mrnas, Scott David Degregorio
T Cell Integrin Dependent, Mkk3/P38 Mapk-Mediated Stabilization Of Labile Cytokine Mrnas, Scott David Degregorio
Yale Medicine Thesis Digital Library
The goal of this project is to elucidate the signaling pathway involved in the T cell integrin lymphocyte function-associated antigen 1 (LFA-1) engagement-mediated, HuR nuclear-to-cytoplasmic translocation and subsequent mRNA stabilization. To examine the pathway transducing LFA-1 engagement-mediated mRNA stabilization, we employed quantitative, real time RT-PCR in the presence of a transcriptional inhibitor to examine the half-life of interferon gamma (IFN-γ) mRNA, a labile cytokine transcript. We used immunofluorescence to observe the nuclear-to-cytoplasmic tranlocation of HuR, an mRNA-binding and stabilizing protein. We also used Western blot analysis to analyze the activity levels of specific mitogen activated protein kinases (MAPKs) upon LFA-1 …
Ethnic Differences In Intramyocellular Lipid Levels And Insulin Resistance In Obese Children And Adolescents, David Liska
Ethnic Differences In Intramyocellular Lipid Levels And Insulin Resistance In Obese Children And Adolescents, David Liska
Yale Medicine Thesis Digital Library
The prevalence of insulin resistance and type 2 diabetes mellitus (T2DM) in obese children and adolescents is growing at an alarming rate, especially in ethnic minorities. It is not clear whether young people of different ethnic backgrounds vary in their metabolic response to excessive adiposity. Differences in lipid partitioning in the abdominal fat compartments have been observed among different ethnic groups. The aim of this study was to evaluate whether there are ethnic differences in intramyocellular lipid (IMCL) levels that are related to differences in insulin sensitivity. Eighty-two obese children and adolescents underwent 1) 1H nuclear magnetic resonance (NMR) spectroscopy …
Treating The Children Of Bolivia Infected With Chagas Disease: A Cost-Benefit Analysis, Gregory A. Magee
Treating The Children Of Bolivia Infected With Chagas Disease: A Cost-Benefit Analysis, Gregory A. Magee
Yale Medicine Thesis Digital Library
The purpose of this study was to perform a cost-benefit analysis of an intervention to treat all the children in Bolivia (under 15 years of age) who are infected with Chagas disease. This research was carried out in La Paz, Bolivia where the author lived for a year collecting data in collaboration with the National Chagas Control Program, Bolivian Ministry of Health. Operational costs were based on current prices for laboratory testing and pharmaceuticals, average hourly wages for health care workers, and the number of children who would be treated. The benefit of the program was estimated as the sum …
Post-Operative Concurrent Chemoradiation With Mitomycin-C For Advanced Head And Neck Cancer, Amar Rewari
Post-Operative Concurrent Chemoradiation With Mitomycin-C For Advanced Head And Neck Cancer, Amar Rewari
Yale Medicine Thesis Digital Library
Purpose: Recent prospective randomized trials have shown concurrent chemo-radiation improves local-regional control in post-operative patients with squamous cell carcinomas of the head and neck (SCCHN) using cis-platinum based regimens. This report pools data from three randomized trials performed at Yale that employed mitomycin-C (MC), selecting those patients treated postoperatively, to evaluate the long term benefit of MC in the postoperative setting and to compare these results with other recently published randomized trials. Methods and Materials: Between 1980 and 1999, a total of 331 SCCHN patients from the three prospective trials were enrolled. Of those patients, 205 were post-operative of which …
Effect Of Pyridostigmine On Heart Rate Recovery After Exercise In Trained Athletes And Sedentary Adults, Thomas Andrew Dewland
Effect Of Pyridostigmine On Heart Rate Recovery After Exercise In Trained Athletes And Sedentary Adults, Thomas Andrew Dewland
Yale Medicine Thesis Digital Library
Acetylcholinesterase inhibition with pyridostigmine has been previously studied in patients with congestive heart failure (CHF), but the effects of this medication on heart rate recovery after exercise and other indices of parasympathetic activity in populations with greater baseline vagal tone has not been fully characterized. Ten healthy, sedentary adults and ten aerobically trained athletes were enrolled in a prospective, double blind, randomized placebo controlled crossover trial. All study subjects were treated with a single dose of oral pyridostigmine 30 mg and matching placebo on separate days. Heart rate variability (HRV) at rest and heart rate recovery (HRR) at one minute …
Onset And Exacerbation Of Obsessive-Compulsive Disorder In Pregnancy And The Postpartum Period, Mariel Aida Focseneanu
Onset And Exacerbation Of Obsessive-Compulsive Disorder In Pregnancy And The Postpartum Period, Mariel Aida Focseneanu
Yale Medicine Thesis Digital Library
The overarching goal of this study was two-fold; to determine the prevalence of perinatal onset or worsening of OCD symptoms in women attending a university-based research program, and to determine whether there is a continuity between perinatal onset or worsening of OCD and premenstrual exacerbation of such symptoms. Women ages 18 to 69 years old that were enrolled in the Yale OCD Research Program between 1990 and 1995 were interviewed by phone or in person regarding demographics, onset and course of OCD, types of primary OCD symptoms, treatment history, comorbid diagnoses including substance use/abuse, and the impact of pregnancy and …
A Quantitative Analysis Of Computed Tomography Scanner Utilization In An Academic Medical Center, Amichai J. Erdfarb
A Quantitative Analysis Of Computed Tomography Scanner Utilization In An Academic Medical Center, Amichai J. Erdfarb
Yale Medicine Thesis Digital Library
The purpose of this study is to quantify computed tomography (CT) scanner utilization and productivity in an academic hospital setting and determine the primary causes of idle time. Two CT scanners were observed for a total of 202 scanner-hours. Scanner time was divided into two primary components: "active" and "idle." Active time was further divided into preparation, scan, and take-down times. Independent variables recorded include in- vs. outpatient, IV contrast (IVC) vs. non-IVC, and scanner type. Primary contributors to idle time were identified in six main categories: preventative maintenance (PM), technical failure, upgrades, calibration, understaffing, and poor flow management. 275 …
Staging, Prognosis, And Treatment Of Merkel Cell Carcinoma: A Population-Based Study, Douglas Michael Housman
Staging, Prognosis, And Treatment Of Merkel Cell Carcinoma: A Population-Based Study, Douglas Michael Housman
Yale Medicine Thesis Digital Library
Merkel cell carcinoma (MCC) is a rare form of skin cancer, often described as the most aggressive cutaneous malignancy. Its high propensity for dermal-lymphatic invasion, local recurrence, and rapid lymphatic and distant metastasis poses a significant treatment challenge to clinicians. Combining its highly aggressive nature with its low incidence, merkel cell carcinoma is a particularly difficult cancer to study. Two major staging criteria exist for Merkel cell carcinoma. The purpose of this study is to validate and compare the Memorial Sloan Kettering Cancer Center (MSKCC) staging criteria with the American Joint Committee on Cancer (AJCC) Tumor, Node, Metastasis (TNM) staging …
Renal Dysfunction, Cardiovascular Risk, And The Response To Ace Inhibition In Patients After Myocardial Infarction, Powell Oliapuram Jose
Renal Dysfunction, Cardiovascular Risk, And The Response To Ace Inhibition In Patients After Myocardial Infarction, Powell Oliapuram Jose
Yale Medicine Thesis Digital Library
Background: Proteinuria is a known cardiovascular risk factor in hypertensive or diabetic patients as well as the general population. Worsening renal function (WRF) has been shown to influence outcomes in the heart failure population. The prognostic value of these markers for renal dysfunction in patients after myocardial infarction is unclear. Methods: The Survival and Ventricular Enlargement trial (SAVE) randomized 2231 patients with left ventricular dysfunction between 3-16 days (average 11 days) post-MI to receive captopril or placebo; those with a serum creatinine above 2.5mg/dl were excluded from SAVE. WRF was defined as an increase in creatinine greater-than 0.3mg/dl measured from …
Comparison Of Mri And Symptom Outcomes Of Uterine Artery Embolization For Uterine Leiomyomata Using Tris-Acryl Gelatin Microspheres, Poly-Vinyl Alcohol Spheres And Poly-Vinyl Alcohol Particles., Jorge Augusto Gálvez Delgado
Comparison Of Mri And Symptom Outcomes Of Uterine Artery Embolization For Uterine Leiomyomata Using Tris-Acryl Gelatin Microspheres, Poly-Vinyl Alcohol Spheres And Poly-Vinyl Alcohol Particles., Jorge Augusto Gálvez Delgado
Yale Medicine Thesis Digital Library
Purpose: To compare the recurrence rate of symptoms and MRI enhancement of uterine fibroids in patients treated with uterine artery embolization (UAE) among three embolic agents: polyvinyl alcohol (PVA) particles, spherical polyvinyl alcohol (SPVA) particles and tris-acryl gelatin microspheres (GM). Materials & Methods: Women treated with UAE for fibroids with PVA, SPVA or GM were contacted by telephone/ mail to complete a modified Uterine Fibroid Symptom Quality of Life (UFS-QOL) survey. Baseline and post-UAE gadolinium-enhanced magnetic resonance imaging (MRI) studies were evaluated for residual or persistent enhancement of any uterine fibroids after UAE. Data was analyzed using 2-tail fishers exact …
Fourteen Years Of Silence: An Exploration Of Intimate Partner Violence In The Jewish Community, Rachel Rose Light
Fourteen Years Of Silence: An Exploration Of Intimate Partner Violence In The Jewish Community, Rachel Rose Light
Yale Medicine Thesis Digital Library
With the background that Jewish women stay in abusive marriages twice as long as their non-Jewish American counterparts, we attempt to understand the religious and cultural factors that may inhibit Jewish women from leaving violent relationships, and examine Scriptural and Rabbinic texts as to Jewish beliefs regarding spousal violence. A variety of academic sources and primary scriptural texts were analyzed for religious and cultural attitudes towards Jewish intimate partner violence. Eight Jewish victims of spousal abuse, five Rabbis and seventeen community support workers were interviewed. Jewish women face a variety of unique issues with regard to how domestic violence is …
Characterizing Prevalence And Severity Of Depression In Coronary Artery Disease Patients In Bangkok, Thailand, Anna Yusim
Yale Medicine Thesis Digital Library
Numerous studies in North America, Europe and Australia have linked depression to increased risk of morbidity and mortality in coronary artery disease (CAD). Although the co-morbidity of depression and CAD is well documented in the western world, little work on the subject has been carried out in Asia. Differing depression presentations in Asia necessitate the use of culture-specific depression rating scales. This study sought to determine whether the correlation between CAD and depression documented in western countries also exists in an Asian nation: Thailand. It was hypothesized that rates of depressive symptoms were higher in Thai inpatients with either unstable …