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Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Orientation Distribution Of Highly Oriented Type I Collagen Deposited On Flat Samples With Different Geometries, Qamrun Nahar, David Minh Luan Quach, Behafarid Darvish, Harvey A. Goldberg, Bernd Grohe, Silvia Mittler
Orientation Distribution Of Highly Oriented Type I Collagen Deposited On Flat Samples With Different Geometries, Qamrun Nahar, David Minh Luan Quach, Behafarid Darvish, Harvey A. Goldberg, Bernd Grohe, Silvia Mittler
Physiology and Pharmacology Publications
The structural arrangement of type I collagen in vivo is critical for the normal functioning of tissues, such as bone, cornea, tendons and blood vessels. At present, there are no established low-cost techniques for fabricating aligned collagen structures for applications in regenerative medicine. Here, we report on a straightforward approach to fabricate collagen films, with defined orientation distributions of collagen fibrillar aggregates within a matrix of oriented collagen molecules on flat sample surfaces. Langmuir Blodgett (LB) technology was used to deposit thin films of oriented type I collagen onto flat substrates exhibiting various shapes. By varying the shapes of the …
Influence Of Electrostatic Forces On The Particle Propulsion In The Evanescent Field Of Silver Ion-Exchanged Waveguides, Dmytro Gebenniko, Silvia Mittler
Influence Of Electrostatic Forces On The Particle Propulsion In The Evanescent Field Of Silver Ion-Exchanged Waveguides, Dmytro Gebenniko, Silvia Mittler
Physiology and Pharmacology Publications
The effect of electrostatic interaction between carboxylate- and amino-functionalized polystyrene particles and a charged waveguide surface on the propulsion speed in an optical tweezers is considered as a function of pH and ionic strength. It was shown that with the variation of the pH of the aqueous solution, the particles were immersed in, a systematic change of propulsion speed with a maximum speed could be achieved. The appearance of a maximum speed was ascribed to changes in the particle-waveguide separation as a result of the combination of two forces: Coulomb repulsion/attraction and induced dipole forces. The highest maximum speed at …
A Biosensor Based On Periodic Arrays Of Gold Nanodisks Under Normal Transmission, Hao Jiang, Tingjie Li, Erden Ertorer, Jun Yang, Jayshri Sabarinathan, Silvia Mittler
A Biosensor Based On Periodic Arrays Of Gold Nanodisks Under Normal Transmission, Hao Jiang, Tingjie Li, Erden Ertorer, Jun Yang, Jayshri Sabarinathan, Silvia Mittler
Physiology and Pharmacology Publications
We present a biosensor based on periodic arrays of gold nanodisks patterned on top of a glass substrate. The sensor’s resonance wavelength, peak linewidth and figure of merit were studied both in experiments and in simulations. We analyzed the dependence of the sensor’s resolution on the inherent figure of merit of the sensor structure and the signal to noise ratio of the detection system. The best achieved refractive index resolution is 1.5×10-4 RIU and the detection limit on and antigen-antibody binding is better than 1 ng/mL.
Loss Of Dendritic Inhibition In The Hippocampus After Repeated Early-Life Hyperthermic Seizures In Rats., Richard Boyce, L Stan Leung
Loss Of Dendritic Inhibition In The Hippocampus After Repeated Early-Life Hyperthermic Seizures In Rats., Richard Boyce, L Stan Leung
Physiology and Pharmacology Publications
Seizures are relatively common in children and are a risk factor for subsequent temporal lobe epilepsy. To investigate whether early-life seizures themselves are detrimental to the proper function of the adult brain, we studied whether dendritic excitation and inhibition in the hippocampus of adult rats were altered after hyperthermia-induced seizures in immature rats. In particular, we hypothesized that apical dendritic inhibition in hippocampal CA1 pyramidal cells would be disrupted following hyperthermia-induced seizures in early life. Seizure rats were given three hyperthermia-induced seizures per day for three days from postnatal day (PND) 13 to 15; control rats were handled similarly but …
Surface Immobilized Gold Nanoparticles By Organometallic Chemical Vapor Deposition On Amine Terminated Glass Surfaces, Erden Ertorer, Jessica C. Avery, Laura C. Pavelka, Silvia Mittler
Surface Immobilized Gold Nanoparticles By Organometallic Chemical Vapor Deposition On Amine Terminated Glass Surfaces, Erden Ertorer, Jessica C. Avery, Laura C. Pavelka, Silvia Mittler
Physiology and Pharmacology Publications
We describe the growth of surface immobilized gold nanoparticles with organometallic chemical vapour deposition (OMCVD) on amine terminated surfaces, utilizing (trimethylphospine)methylgold ((CH3)3PAuCH3) precursor. Samples fabricated using different deposition times were characterized by UV-Vis spectroscopy and scanning electron microscopy. Particle stability on the samples was tested by washing and rinsing treatments with various organic solvents. A biotin-streptavidin scheme was applied to demonstrate the biosensing capabilities of the samples. The size, interparticle distance, and shape of the gold nanoparticles demonstrated that OMCVD is a simple, economic, and fast way to fabricate surface bonded and stable gold nanoparticles. The plasmonic properties, the stability …
Acute Vibration Induces Transient Expression Of Anabolic Genes In The Murine Intervertebral Disc, Matthew R. Mccann, Priya Patel, Kim L. Beaucage, Yizhi Xiao, Corey Bacher, Walter L. Siqueira, David W. Holdsworth, S. Jeffrey Dixon, Cheryle A. Séguin
Acute Vibration Induces Transient Expression Of Anabolic Genes In The Murine Intervertebral Disc, Matthew R. Mccann, Priya Patel, Kim L. Beaucage, Yizhi Xiao, Corey Bacher, Walter L. Siqueira, David W. Holdsworth, S. Jeffrey Dixon, Cheryle A. Séguin
Physiology and Pharmacology Publications
No abstract provided.
Periodic Arrays Of Gold Nano-Disks Coupled With Evanescent Spectroscopy, Hao Jiang, Touraj Manifar, Aref Bakhtazad, Hossein Hojjati, Jayshr Sabarinathan, Silvia Mittler
Periodic Arrays Of Gold Nano-Disks Coupled With Evanescent Spectroscopy, Hao Jiang, Touraj Manifar, Aref Bakhtazad, Hossein Hojjati, Jayshr Sabarinathan, Silvia Mittler
Physiology and Pharmacology Publications
We study and analyze various spectral features of gold nano-disk arrays coupled with the evanescent field of an optical waveguide using finite difference time domain simulations for comparison to our previous work on this topic (Jiang et al, Journal of Lightwave Technology 27, no.13, (2009): 2264-2270). We find that the quadrupolar and dipolar peaks are both heavily dependent on the coherent interactions of the periodic array and show comparable performance for refractive index sensing applications. We also find sharp extinction peaks and dips in the simulated spectra, but they are not sensitive to the index change of the surface-bound layer. …