Medicine and Health Sciences Commons^™

Investigation Of Molecular Mechanisms Of Liver Preservation Injury: A Complication Preceding Organ Transplantation, Ria C. Fyffe-Freil

Theses and Dissertations

Of the over 108,000 American awaiting a life-saving organ transplant today, over 12,000 (11%) of those need a new liver (OPTN, 2020). Last year, only 35% of patients on the waiting list for an organ were transplanted. Improving the quality of marginal organs by preventing or reversing preservation injury could vastly increase the number of transplants performed. Washout of circulating blood during liver procurement with cold University of Wisconsin solution flushes out any endogenous pro-survival signaling molecules. We investigated lysophospholipid (LPL) surface receptors (G-protein coupled receptors for lysophosphatidic acid (LPA) and sphingosine- 1-phosphate (S1P)) and their role in protecting hepatocytes …

Alcoholic Liver Diseases, Stem Cell Disorder And Hepatocellular Carcinoma, Shoujun Gu, Shuyun Rao, Sobia Zaidi, Kazufumi Ohshiro, Jian Chen, Wilma Jogunoori, Jon White, Nagarajan Pattabiraman, Raja Mazumder, Anelia Horvath, Ray-Chang Wu, Sjhulin Li, Chu-Xia Deng, Rehan Akbani, Bibhuti Mishra, Lopa Mishra

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Convergence Of Wnt/Beta-Catenin And Mtor Signaling In Liver Physiology And Hepatocellular Carcinoma, Adeola O. Adebayo Michael, Junyan Tao, Satdarshan P. Monga

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

The Scaffolding Protein Iqgap1 Promotes Hepatic Proliferation And Protects The Liver From Injury, Hanna Erickson, Sayeepriyadarshini Anakk

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Characterization Of Staphylococcal Nuclease And Tudor Domain Containing Protein 1 (Snd1) As A Molecular Target In Hepatocellular Carcinoma And Non-Alcoholic Steatohepatitis, Nidhi H. Jariwala

Theses and Dissertations

CHARACTERIZATION OF STAPHYLOCOCCAL NUCLEASE AND TUDOR DOMAIN CONTAINING PROTEIN 1 (SND1) AS A MOLECULAR TARGET IN HEPATOCELLULAR CARCINOMA AND NON-ALCOHOLIC STEATOHEPATITIS

Nidhi Jariwala, PhD

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Integrative Life Sciences

Virginia Commonwealth University, 2017

Devanand Sarkar, M.B.B.S., PhD.

Associate Professor, Department of Human and Molecular Genetics

Virginia Commonwealth University

Richmond, Virginia

SND1, a subunit of the miRNA regulatory complex RISC, has been implicated as an oncogene in hepatocellular carcinoma (HCC). Oncoprotein SND1 regulates gene expression at a post-transcriptional level in multiple cancers including hepatocellular carcinoma (HCC). …

The Prevalence Of Comorbid Chronic Disease In Virginia's Adult Patient Population During The Years 2001 And 2004, Joseph D. Schwartz

Theses and Dissertations

Objective: Chronic disease comorbidities, on the rise in the U.S. and Virginia, represent a new challenge to the way medicine is practiced and prescribed. This descriptive study uses Virginia hospital discharge data to describe the prevalence and trends of chronic disease comorbidities present in the state's over-45 population during the years 2001 and 2004.Methods: Data collected by Virginia Health Information was utilized. Adults over the age of 45 years and who selected for race and location were included in this analysis, with an aggregate sample size of 813,336 (N=458,593 [2001]; N=364,743 [2004]). Pearson chi-square analyses determined significant sample population differences …

Abstracts Of Theses For Graduate Degrees

MCV/Q, Medical College of Virginia Quarterly

Medical College of Virginia, June, 1969. Summary includes: Anticholinergic Agents Based on Ariens' Dual Receptor Site Theory by Archie Jay Beebe; The Relationship Between Emotionality and Behavioral Performance in a Random Population of Male Charles River Rats by Stanley F. Bernstein; Fetal Development and Functional Significance of the Epiphysis Cerebri in Rats and Hamsters: A Light and Electron Microscopic Investigation by Jeanne W. Clabough; Separation and Partial Characterization of Components Derived from Human Erythrocyte Membranes by Roy Frederick J. Davis; Free Amino Acid Release from Isolated Rat Liver Cells by Gerald Irwin Drury; Passer Domesticus by William W. Farrar; The …