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Full-Text Articles in Medicine and Health Sciences
Obesity And Asthma: Adiponectin Receptor 1 (Adipo R1) And Adiponectin Receptor 2 (Adipo R2) Are Expressed By Normal Human Bronchial Epithelial (Nhbe) Cells At Air-Liquid Interface (Ali) And Expression Changes With Il-13 Stimulation, Jennifer L. Bradley
Theses and Dissertations
Obesity is recognized as an important risk factor for the development of many chronic diseases such as hypertension, Type 2 diabetes mellitus (T2DM) cardiovascular disease, cancer, renal disease, neurologic dysfunction, metabolic syndrome and asthma (3, 4). Circulating serum adiponectin levels in obese asthmatics have been reported to be low. Therefore, we aimed to investigate the role of adiponectin in a mucus hypersecretion model and hypothesized that adiponectin would decrease IL-13 induced MUC5AC expression from differentiated NHBE cells and that increasing concentrations of IL-13 would cause a decrease in Adipo R1 and Adipo R2 expression. MUC5AC expression with exposure to adiponectin …
Resistance Exercise And Vascular Function: Training And Obesity-Related Effects, Grayson Lipford
Resistance Exercise And Vascular Function: Training And Obesity-Related Effects, Grayson Lipford
Theses and Dissertations
Endothelial dysfunction, or the inability of an artery to dilate sufficiently when subjected to excessive shear stress, serves both as a predictor of future cardiovascular events as well as an early indication of atherosclerosis. Several chronic disease states, including obesity, have been shown to alter endothelial function, which may be mediated through circulating pro- and anti-inflammatory adipokines. Still, the mechanisms by which obesity-related low-grade inflammation alters endothelial function are not fully elucidated. Acute and chronic endurance exercise training has previously been shown to be effective in improving endothelial function; however, chronic resistance exercise training is not universally regarded as beneficial …