Medicine and Health Sciences Commons^™

Cauti: What Are We Testing?, Christoph Lecznar

VCU Health Nursing

Purpose: The purpose of this evidence-based practice (EBP) project was to identify and implement evidence-based practice to reduce Catheter-Associated Urinary Tract Infections (CAUTI).

Background: CAUTIs are deemed never events by Centers for Medicaid and Medicare and are tied to financial reimbursements. CDC states 17-69% of CAUTIs are preventable with recommended infection control measures. UTIs are the most common type of Hospital-acquired infection, with an estimated of occurrence of 9.5% reported by acute care hospitals. Every day a catheter is in place, the risk of CAUTI increases by 3-7%. Current recommendations for reduction in CAUTI rates include educational strategies, catheter avoidance, …

Dendrimer-Based Antibiotics For The Treatment Of Bacterial Biofilm In Cystic Fibrosis (Cf), Younan Ma

Theses and Dissertations

Pseudomonas aeruginosa (PA) is the predominant pathogen in chronic lung infections of cystic fibrosis (CF) patients. The most important mechanism of adaptation of PA to host defense and antibiotic treatment is the formation of biofilms within the mucus layer covering the lung bronchi. The effectiveness of antibiotics such as aminoglycosides is significantly attenuated by their limited penetration through thick mucus and embedded biofilm matrix in patients’ lung. Inhaled tobramycin (Tobra), which is the most commonly used antibiotics in the treatment of PA infections for CF patients, is usually found to be in very high concentration in patients’ lung, and yet …