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Virginia Commonwealth University

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2018

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Full-Text Articles in Medicine and Health Sciences

Untargeted Lipidomic Analysis To Broadly Characterize The Effects Of Pathogenic And Non-Pathogenic Staphylococci On Mammalian Lipids, Naren Gajenthra Kumar, Daniel Contaifer Jr., Paul Rs Baker, Kim Ekroos, Kimberly K. Jefferson, Dayanjan S. Wijesinghe Jan 2018

Untargeted Lipidomic Analysis To Broadly Characterize The Effects Of Pathogenic And Non-Pathogenic Staphylococci On Mammalian Lipids, Naren Gajenthra Kumar, Daniel Contaifer Jr., Paul Rs Baker, Kim Ekroos, Kimberly K. Jefferson, Dayanjan S. Wijesinghe

Pharmacotherapy and Outcomes Science Publications

Modification of the host lipidome via secreted enzymes is an integral, but often overlooked aspect of bacterial pathogenesis. In the current era of prevalent antibiotic resistance, knowledge regarding critical host pathogen lipid interactions has the potential for use in developing novel antibacterial agents. While most studies to date on this matter have focused on specific lipids, or select lipid classes, this provides an incomplete picture. Modern methods of untargeted lipidomics have the capacity to overcome these gaps in knowledge and provide a comprehensive understanding of the role of lipid metabolism in the pathogenesis of infections. In an attempt to determine …


Implementing Parallel Spreadsheet Models For Health Policy Decisions: The Impact Of Unintentional Errors On Model Projections, Stephanie L. Bailey, Rose S. Bono, Denis Nash, April D. Kimmel Jan 2018

Implementing Parallel Spreadsheet Models For Health Policy Decisions: The Impact Of Unintentional Errors On Model Projections, Stephanie L. Bailey, Rose S. Bono, Denis Nash, April D. Kimmel

Health Behavior and Policy Publications

Background

Spreadsheet software is increasingly used to implement systems science models informing health policy decisions, both in academia and in practice where technical capacity may be limited. However, spreadsheet models are prone to unintentional errors that may not always be identified using standard error-checking techniques. Our objective was to illustrate, through a methodologic case study analysis, the impact of unintentional errors on model projections by implementing parallel model versions.

Methods

We leveraged a real-world need to revise an existing spreadsheet model designed to inform HIV policy. We developed three parallel versions of a previously validated spreadsheet-based model; versions differed by …


Social Determinants Of Smoke Exposure During Pregnancy: Findings From Waves 1 & 2 Of The Population Assessment Of Tobacco And Health (Path) Study, Elizabeth K. Do, Tiffany L. Green, Elizabeth C. Prom-Wormley, Bernard F. Fuemmeler Jan 2018

Social Determinants Of Smoke Exposure During Pregnancy: Findings From Waves 1 & 2 Of The Population Assessment Of Tobacco And Health (Path) Study, Elizabeth K. Do, Tiffany L. Green, Elizabeth C. Prom-Wormley, Bernard F. Fuemmeler

Health Behavior and Policy Publications

Maternal smoking during pregnancy (MSDP) and secondhand smoke (SHS) exposure are associated with a myriad of negative health effects for both mother and child. However, less is known regarding social determinants for SHS exposure, which may differ from those of maternal smoking during pregnancy (MSDP). To identify social determinants for SHS exposure only, MSDP only, and MSDP and SHS exposure, data were obtained from all pregnant women (18–54 years; N = 726) in waves 1 and 2 of the Population Assessment of Tobacco and Health Study (2014–2015). Multiple logistic regressions were conducted using SAS 9.4. Smoke exposure during pregnancy was …


Affect, Interpersonal Behaviour And Interpersonal Perception During Open-Label, Uncontrolled Paroxetine Treatment Of People With Social Anxiety Disorder: A Pilot Study, Lance M. Rappaport, Jennifer J. Russell, Donald Hedeker, Gilbert Pinard, Pierre Bleau, Debbie S. Moskowitz Jan 2018

Affect, Interpersonal Behaviour And Interpersonal Perception During Open-Label, Uncontrolled Paroxetine Treatment Of People With Social Anxiety Disorder: A Pilot Study, Lance M. Rappaport, Jennifer J. Russell, Donald Hedeker, Gilbert Pinard, Pierre Bleau, Debbie S. Moskowitz

Psychiatry Publications

Background: Laboratory-based research with community samples has suggested changes in affective, behavioural and cognitive processes as possible explanations for the effects of serotonergic medications. Examining the effects of serotonergic medications using an ecological momentary measure (such as event-contingent recording) in the daily lives of people with social anxiety disorder would contribute to establishing the effects of these medications on affect, behaviour and one form of cognition: perception of others’ behaviour.

Methods: The present study assessed changes in affect, interpersonal behaviour and perception of others’ behaviour in adults with social anxiety disorder using ecological momentary assessment at baseline and over 4 …


Kinetics And Inhibition Studies Of The L205r Mutant Of Camp-Dependent Protein Kinase Involved In Cushing’S Syndrome, Nicole M. Luzi, Charles E. Lyons, Darrell L. Peterson, Keith C. Ellis Jan 2018

Kinetics And Inhibition Studies Of The L205r Mutant Of Camp-Dependent Protein Kinase Involved In Cushing’S Syndrome, Nicole M. Luzi, Charles E. Lyons, Darrell L. Peterson, Keith C. Ellis

Medicinal Chemistry Publications

Overproduction of cortisol by the hypothalamus–pituitary–adrenal hormone system results in the clinical disorder known as Cushing's syndrome. Genomics studies have identified a key mutation (L205R) in the α‐isoform of the catalytic subunit of cAMP‐dependent protein kinase (PKACα) in adrenal adenomas of patients with adrenocorticotropic hormone‐independent Cushing's syndrome. Here, we conducted kinetics and inhibition studies on the L205R‐PKACα mutant. We have found that the L205R mutation affects the kinetics of both Kemptide and ATP as substrates, decreasing the catalytic efficiency (kcat/KM) for each substrate by 12‐fold and 4.5‐fold, respectively. We have also determined the IC …


Triangulating Abuse Liability Assessment For Flavoured Cigar Products Using Physiological, Behavioural Economic And Subjective Assessments: A Within-Subjects Clinical Laboratory Protocol, Catherine S. Wall, Rose S. Bono, Rebecca C. Lester, Cosima Hoetger, Thokozeni Lipato, Mignonne C. Guy, Thomas E. Eissenberg, Warren K. Bickel, Andrew J. Barnes, Caroline O. Cobb Jan 2018

Triangulating Abuse Liability Assessment For Flavoured Cigar Products Using Physiological, Behavioural Economic And Subjective Assessments: A Within-Subjects Clinical Laboratory Protocol, Catherine S. Wall, Rose S. Bono, Rebecca C. Lester, Cosima Hoetger, Thokozeni Lipato, Mignonne C. Guy, Thomas E. Eissenberg, Warren K. Bickel, Andrew J. Barnes, Caroline O. Cobb

Health Behavior and Policy Publications

Introduction
In the USA, Food and Drug Administration regulations prohibit the sale of flavoured cigarettes, with menthol being the exception. However, the manufacture, advertisement and sale of flavoured cigar products are permitted. Such flavourings influence positive perceptions of tobacco products and are linked to increased use. Flavourings may mask the taste of tobacco and enhance smoke inhalation, influencing toxicant exposure and abuse liability among novice tobacco users. Using clinical laboratory methods, this study investigates how flavour availability affects measures of abuse liability in young adult cigarette smokers. The specific aims are to evaluate the effect of cigar flavours on nicotine …


Mandatory Minimum Sentencing Policies And Cocaine Use In The U.S., 1985–2013, Lauryn Saxe Walker, Briana Mezuk Jan 2018

Mandatory Minimum Sentencing Policies And Cocaine Use In The U.S., 1985–2013, Lauryn Saxe Walker, Briana Mezuk

Health Behavior and Policy Publications

Background: As of May 2017, the United States federal government renewed its prioritization for the enforcement of mandatory minimum sentences for illicit drug offenses. While the effect of such policies on racial disparities in incarceration is well-documented, less is known about the extent to which these laws are associated with decreased drug use. This study aims to identify changes in cocaine use associated with mandatory minimum sentencing policies by examining differential sentences for powder and crack cocaine set by the Anti-Drug Abuse Act (ADAA) (100:1) and the Fair Sentencing Act (FSA), which reduced the disparate sentencing to 18:1.


Methods: Using …


Oral Cancer Has A New Risk Factor: Hpv, Tira Hanrahan, Shillpa Naavaal Jan 2018

Oral Cancer Has A New Risk Factor: Hpv, Tira Hanrahan, Shillpa Naavaal

Dental Public Health and Policy Publications

No abstract provided.


Training Neurodegenerative Disease Support Group Leaders: A New Support Group Functioning Scale, Therese V. Cash, Christopher Kilbourn, Sarah K. Lageman Jan 2018

Training Neurodegenerative Disease Support Group Leaders: A New Support Group Functioning Scale, Therese V. Cash, Christopher Kilbourn, Sarah K. Lageman

Neurology Publications

Support group leaders play pivotal roles in maintaining healthy community support groups; however, these leaders also have personal support needs and typically lack formal training in managing complex behaviors of neurodegenerative disorders. A support group well-being questionnaire, assessing support group functioning, was developed and piloted among participants of an educational training program designed for support group leaders of various neurodegenerative disorder-specific support groups. An exploratory factor analysis evaluated the questionnaire’s psychometric properties and identified a reliable single factor five-item solution, which was titled the Support Group Functioning Scale (SGFS). Preliminary interpretation guidelines were proposed. Development of this scale is a …


A Chromosomal Deletion And New Frameshift Mutation Cause Arsacs In An African-American, Sean C. Dougherty, Amy Harper, Hind Al Saif, Gregory Vorona, Scott R. Haines Jan 2018

A Chromosomal Deletion And New Frameshift Mutation Cause Arsacs In An African-American, Sean C. Dougherty, Amy Harper, Hind Al Saif, Gregory Vorona, Scott R. Haines

Neurology Publications

Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is a rare, progressive, neurodegenerative disease characterized by ataxia, spasticity and polyneuropathy. First described in the French-Canadian population of Quebec in 1978, ARSACS has since been identified in multiple patients worldwide. In this clinical case report, we describe the evaluation of an 11-years-old African-American male who presented to neuromuscular clinic for assessment of a gait abnormality. He had a history of gross motor delay since early childhood, frequent falls and a below average IQ. Chromosomal microarray revealed a 1.422 megabase loss in the 13q12.12 region, which includes the SACS gene. Next Generation Sequencing …


Identifying Medication Management Smartphone App Features Suitable For Young Adults With Developmental Disabilities: Delphi Consensus Study, Teresa M. Salgado, Alexa Fedrigon, Donna Riccio Omichinski, Michelle A. Meade, Karen B. Farris Jan 2018

Identifying Medication Management Smartphone App Features Suitable For Young Adults With Developmental Disabilities: Delphi Consensus Study, Teresa M. Salgado, Alexa Fedrigon, Donna Riccio Omichinski, Michelle A. Meade, Karen B. Farris

Pharmacotherapy and Outcomes Science Publications

Background: Smartphone apps can be a tool to facilitate independent medication management among persons with developmental disabilities. At present, multiple medication management apps exist in the market, but only 1 has been specifically designed for persons with developmental disabilities. Before initiating further app development targeting this population, input from stakeholders including persons with developmental disabilities, caregivers, and professionals regarding the most preferred features should be obtained.

Objective: The aim of this study was to identify medication management app features that are suitable to promote independence in the medication management process by young adults with developmental disabilities using a Delphi consensus …


Variability In Antifungal Utilization Among Neonatal, Pediatric, And Adult Inpatients In Academic Medical Centers Throughout The United States Of America, Jeremy S. Stultz, Rose Kohinke, Amy L. Pakyz Jan 2018

Variability In Antifungal Utilization Among Neonatal, Pediatric, And Adult Inpatients In Academic Medical Centers Throughout The United States Of America, Jeremy S. Stultz, Rose Kohinke, Amy L. Pakyz

Pharmacotherapy and Outcomes Science Publications

Background
Identification of factors associated with antifungal utilization in neonatal, pediatric, and adult patient groups is needed to guide antifungal stewardship initiatives in academic medical centers.

Methods
For this hospital-level analysis, we analyzed antifungal use in hospitals across the United States of America, excluding centers only providing care for hematology/oncology patients. Analysis of variance was used to compare antifungal use between patient groups. Three multivariable linear regression models were used to determine independent factors associated with antifungal use in the neonatal, pediatric, and adult patient groups.

Results
For the neonatal, pediatric, and adult patient groups, 54, 44, and 60 hospitals …


Review: Do The Different Sensory Areas Within The Cat Anterior Ectosylvian Sulcal Cortex Collectively Represent A Network Multisensory Hub?, M. Alex Meredith, Mark T. Wallace, H. Ruth Clemo Jan 2018

Review: Do The Different Sensory Areas Within The Cat Anterior Ectosylvian Sulcal Cortex Collectively Represent A Network Multisensory Hub?, M. Alex Meredith, Mark T. Wallace, H. Ruth Clemo

Anatomy and Neurobiology Publications

Current theory supports that the numerous functional areas of the cerebral cortex are organized and function as a network. Using connectional databases and computational approaches, the cerebral network has been demonstrated to exhibit a hierarchical structure composed of areas, clusters and, ultimately, hubs. Hubs are highly connected, higher-order regions that also facilitate communication between different sensory modalities. One region computationally identified network hub is the visual area of the Anterior Ectosylvian Sulcal cortex (AESc) of the cat. The Anterior Ectosylvian Visual area (AEV) is but one component of the AESc that also includes the auditory (Field of the Anterior Ectosylvian …


Framing And Visual Type: Effect On Future Zika Vaccine Uptake Intent, Jeanine P.D. Guidry, Kellie E. Carlyle, Jessica G. Larose, Paul Perrin, Mark Ryan, Marcus Messner, Jay Adams Jan 2018

Framing And Visual Type: Effect On Future Zika Vaccine Uptake Intent, Jeanine P.D. Guidry, Kellie E. Carlyle, Jessica G. Larose, Paul Perrin, Mark Ryan, Marcus Messner, Jay Adams

Richard T. Robertson School of Media and Culture Publications

Introduction: The Zika virus is associated with the birth defect microcephaly, and while a vaccine was not available in early- 2017, several were under development. This study’s purpose was to identify effective communication strategies to promote uptake of a new vaccine, particularly among women of reproductive age.

Design and methods: In order to study the effects of Zika message framing (gain vs. loss) and visual type (photo vs. infographic) on future Zika vaccine uptake intent, a 2×2 between-subjects experiment was performed via an online survey in 2017 among 339 U.S. women of reproductive age (18-49 years). Participants were …


"Epigenetic Silencing Of Socs3 Expression Contributes To Fibrosis In Crohn’S Disease", Emily T. Marshall, Chao Li, John F. Kuemmerle Jan 2018

"Epigenetic Silencing Of Socs3 Expression Contributes To Fibrosis In Crohn’S Disease", Emily T. Marshall, Chao Li, John F. Kuemmerle

MD Student Summer Research Fellowship Program Posters

Identified risk polymorphisms affecting the Jak-STAT3 pathway in patients with Crohn’s disease could affect TGF-β1 and collagen I expression and in the pathway’s negative regulator, SOCS3. Genetic factors, however, account for only ~25% of disease. Epigenetic events also shape gene expression. Recent experiments showed that autocrine IL-6 production in mesenchymal cells, subepithelial myofibroblasts (SEMF) and muscle cells, of patients with fibrostenotic Crohn’s disease causes sustained Jak-STAT3 activity, excess TGF-β1 and Collagen I production and fibrosis. SOCS3 paradoxically decreased in these cells. We now identify epigenetic mechanisms that silence SOCS3 expression in SEMF of patients with fibrostenotic Crohn’s disease. In a …


Contraceptive Utilization Among New Exotic Dancers: A Cross-Sectional Study, Mishka Terplan, Caitlin E. Martin, Jennifer Nail, Susan G. Sherman Jan 2018

Contraceptive Utilization Among New Exotic Dancers: A Cross-Sectional Study, Mishka Terplan, Caitlin E. Martin, Jennifer Nail, Susan G. Sherman

Obstetrics and Gynecology Publications

Background
Female exotic dancers are a population at high risk of unintended pregnancy. The objective of this study is to describe the reproductive health needs and contraceptive utilization of exotic dancers.

Methods
New exotic dancers (< 6 months dancing) from 26 clubs in Baltimore City/County completed a one-time survey.

Results
Of 117 participants, 96 (82%) had current contraceptive need. The mean age was 24 years, and 55% were black. Sex work (45%), alcohol use disorder (73%), illicit (44%; e.g., heroin, crack, cocaine), and injection drug use (8%) were common. The majority (66%) reported contraception use in the prior 6 months. Condoms were reported by 46% whereas 45% reported non-barrier methods, most commonly hormonal …


Wses Worldwide Emergency General Surgery Formation And Evaluation Project, Federico Coccolini, Yoram Kluger, Luca Ansaloni, Ernest E. Moore, Raul Coimbra, Gustavo P. Fraga, Andrew Kirkpatrick, Andrew Peitzman, Ron Maier, Gianluca Baiocchi, Vanni Agnoletti, Emiliano Gamberini, Ari Leppaniemi, Rao Ivatury, Michael Sugrue, Massimo Sartelli, Salomone Di Saverio, Walt Biffl, Fausto Catena Jan 2018

Wses Worldwide Emergency General Surgery Formation And Evaluation Project, Federico Coccolini, Yoram Kluger, Luca Ansaloni, Ernest E. Moore, Raul Coimbra, Gustavo P. Fraga, Andrew Kirkpatrick, Andrew Peitzman, Ron Maier, Gianluca Baiocchi, Vanni Agnoletti, Emiliano Gamberini, Ari Leppaniemi, Rao Ivatury, Michael Sugrue, Massimo Sartelli, Salomone Di Saverio, Walt Biffl, Fausto Catena

Surgery Publications

Optimal management of emergency surgical patients represents one of the major health challenges worldwide. Emergency general surgery (EGS) was identified as multidisciplinary surgery performed for traumatic and nontraumatic acute conditions during the same admission in the hospital. EGS represents the easiest viable way to provide affordable and high-quality level of care to emergency surgical and trauma patients. It may result from the association of different physicians with other specialties in a cooperative model. The World Society of Emergency Surgery (WSES) has been working on the EGS organization and implementation since its foundation believing in the need of common benchmarks for …


Circulation First – The Time Has Come To Question The Sequencing Of Care In The Abcs Of Trauma; An American Association For The Surgery Of Trauma Multicenter Trial, Paula Ferrada, Rachael A. Callcut, David J. Skarupa, Therese M. Duane, Alberto Garcia, Kenji Inaba, Desmond Khor, Vincent Anto, Jason Sperry, David Turay, Rachel M. Nygaard, Martin A. Schreiber, Toby Enniss, Michelle Mcnutt, Herb Phelan, Kira Smith, Forrest O. Moore, Irene Tabas, Joseph Dubose, Aast Multi-Institutional Trials Committee Jan 2018

Circulation First – The Time Has Come To Question The Sequencing Of Care In The Abcs Of Trauma; An American Association For The Surgery Of Trauma Multicenter Trial, Paula Ferrada, Rachael A. Callcut, David J. Skarupa, Therese M. Duane, Alberto Garcia, Kenji Inaba, Desmond Khor, Vincent Anto, Jason Sperry, David Turay, Rachel M. Nygaard, Martin A. Schreiber, Toby Enniss, Michelle Mcnutt, Herb Phelan, Kira Smith, Forrest O. Moore, Irene Tabas, Joseph Dubose, Aast Multi-Institutional Trials Committee

Surgery Publications

Background

The traditional sequence of trauma care: Airway, Breathing, Circulation (ABC) has been practiced for many years. It became the standard of care despite the lack of scientific evidence. We hypothesized that patients in hypovolemic shock would have comparable outcomes with initiation of bleeding treatment (transfusion) prior to intubation (CAB), compared to those patients treated with the traditional ABC sequence.

Methods

This study was sponsored by the American Association for the Surgery of Trauma multicenter trials committee. We performed a retrospective analysis of all patients that presented to trauma centers with presumptive hypovolemic shock indicated by pre-hospital or emergency department …


Low Nt-Probnp Levels In Overweight And Obese Patients Do Not Rule Out A Diagnosis Of Heart Failure With Preserved Ejection Fraction, Leo F. Buckley, Justin M. Canada, Marco G. Del Buono, Salvatore Carbone, Cory R. Trankle, Hayley Billingsley, Dinesh Kadariya, Ross Arena, Benjamin W. Van Tassell, Antonio Abbate Jan 2018

Low Nt-Probnp Levels In Overweight And Obese Patients Do Not Rule Out A Diagnosis Of Heart Failure With Preserved Ejection Fraction, Leo F. Buckley, Justin M. Canada, Marco G. Del Buono, Salvatore Carbone, Cory R. Trankle, Hayley Billingsley, Dinesh Kadariya, Ross Arena, Benjamin W. Van Tassell, Antonio Abbate

Internal Medicine Publications

Background Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome that presents clinicians with a diagnostic challenge. The use of natriuretic peptides to exclude a diagnosis of HFpEF has been proposed. We sought to compare HFpEF patients with N-terminal pro-brain natriuretic peptide (NT-proBNP) level above and below the proposed cut-off.

Methods Stable patients (n = 30) with left ventricular (LV) ejection fraction ≥ 50% were eligible if they had a diagnosis of HF according to the European Society of Cardiology diagnostic criteria. Characteristics of patients with NT-proBNP below (≤125 pg/mL) and above (>125 pg/mL) the diagnostic …


Intestine‐Specific Expression Of Human Chimeric Intestinal Alkaline Phosphatase Attenuates Western Diet‐Induced Barrier Dysfunction And Glucose Intolerance, Siddhartha S. Ghosh, Hongliang He, Jing Wang, William Korzun, Paul J. Yannie, Shobha Ghosh Jan 2018

Intestine‐Specific Expression Of Human Chimeric Intestinal Alkaline Phosphatase Attenuates Western Diet‐Induced Barrier Dysfunction And Glucose Intolerance, Siddhartha S. Ghosh, Hongliang He, Jing Wang, William Korzun, Paul J. Yannie, Shobha Ghosh

Internal Medicine Publications

Intestinal epithelial cell derived alkaline phosphatase (IAP) dephosphorylates/detoxifies bacterial endotoxin lipopolysaccharide (LPS) in the gut lumen. We have earlier demonstrated that consumption of high‐fat high‐cholesterol containing western type‐diet (WD) significantly reduces IAP activity, increases intestinal permeability leading to increased plasma levels of LPS and glucose intolerance. Furthermore, oral supplementation with curcumin that increased IAP activity improved intestinal barrier function as well as glucose tolerance. To directly test the hypothesis that targeted increase in IAP would protect against WD‐induced metabolic consequences, we developed intestine‐specific IAP transgenic mice where expression of human chimeric IAP is under the control of intestine‐specific villin promoter. …


Autophagy-Deficient Breast Cancer Shows Early Tumor Recurrence And Escape From Dormancy, Masoud H. Manjili Jan 2018

Autophagy-Deficient Breast Cancer Shows Early Tumor Recurrence And Escape From Dormancy, Masoud H. Manjili

Massey Comprehensive Cancer Center Publications

Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse earlier than others. In addition, some tumor clones respond to immunotherapy while others do not. We investigated how autophagy plays a role in accelerating or delaying recurrence of neu-overexpressing mouse mammary carcinoma (MMC) following adriamycin (ADR) treatment, and in affecting response to immunotherapy. We explored two strategies: 1) transient blockade of autophagy with chloroquine (CQ), which blocks fusion of autophagosomes …


Determining The Quantitative Principles Of T Cell Response To Antigenic Disparity In Stem Cell Transplantation, Ali Salman, Vishal Koparde, Charles E. Hall, Max Jameson-Lee, Catherine Roberts, Myrna Serrano, Badar Abdulrazzaq, Jeremy Meier, Caleb Kennedy, Masoud H. Manjili, Stephen R. Spellman, Dayanjan Wijesinghe, Shahrukh Hashmi, Greg Buck, Rehan Qayyum, Michael Neale, Jason Reed, Amir A. Toor Jan 2018

Determining The Quantitative Principles Of T Cell Response To Antigenic Disparity In Stem Cell Transplantation, Ali Salman, Vishal Koparde, Charles E. Hall, Max Jameson-Lee, Catherine Roberts, Myrna Serrano, Badar Abdulrazzaq, Jeremy Meier, Caleb Kennedy, Masoud H. Manjili, Stephen R. Spellman, Dayanjan Wijesinghe, Shahrukh Hashmi, Greg Buck, Rehan Qayyum, Michael Neale, Jason Reed, Amir A. Toor

Massey Comprehensive Cancer Center Publications

Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA matching of donors and recipients. This has its origin in the variation between the exomes of the two, which provides the basis for minor histocompatibility antigens (mHA). The mHA presented on the HLA class I and II molecules and the ensuing T cell response to these antigens results in graft vs. host disease. In this paper, results of a whole exome sequencing study are presented, with resulting alloreactive polymorphic peptides and their HLA class I and HLA class II (DRB1) binding affinity quantified. Large libraries of potentially alloreactive …


Exploring Resilience Models In A Sample Of Combat-Exposed Military Service Members And Veterans: A Comparison And Commentary, Christina M. Sheerin, Kelcey J. Stratton, Ananda B. Amstadter, The Va Mid-Atlantic Mental Illness Research, Education, Clinical Center (Mirecc) Workgroup, Scott D. Mcdonald Jan 2018

Exploring Resilience Models In A Sample Of Combat-Exposed Military Service Members And Veterans: A Comparison And Commentary, Christina M. Sheerin, Kelcey J. Stratton, Ananda B. Amstadter, The Va Mid-Atlantic Mental Illness Research, Education, Clinical Center (Mirecc) Workgroup, Scott D. Mcdonald

Psychiatry Publications

Background: The term resilience is applied in numerous ways in the mental health field, leading to different perspectives of what constitutes a resilient response and disparate findings regarding its prevalence following trauma.

Objective: illustrate the impact of various definitions on our understanding and prevalence of resilience, we compared various resilience definitions (absence of PTSD, absence of current mental health diagnosis, absence of generalized psychological distress, and an alternative trauma load–resilience discrepancy model of the difference between actual and predicted distress given lifetime trauma exposure) within a combat-exposed military personnel and veteran sample.

Method: In this combat-trauma exposed …


Supporting Play Exploration And Early Developmental Intervention Versus Usual Care To Enhance Development Outcomes During The Transition From The Neonatal Intensive Care Unit To Home: A Pilot Randomized Controlled Trial, Stacey C. Dusing, Tanya Tripathi, Emily C. Marcinowski, Leroy R. Thacke, Lisa F. Brown, Karen D. Hendricks-Muñoz Jan 2018

Supporting Play Exploration And Early Developmental Intervention Versus Usual Care To Enhance Development Outcomes During The Transition From The Neonatal Intensive Care Unit To Home: A Pilot Randomized Controlled Trial, Stacey C. Dusing, Tanya Tripathi, Emily C. Marcinowski, Leroy R. Thacke, Lisa F. Brown, Karen D. Hendricks-Muñoz

Physical Therapy Publications

Background

While therapy services may start in the Neonatal Intensive Care Unit (NICU) there is often a gap in therapy after discharge. Supporting Play Exploration and Early Development Intervention (SPEEDI) supports parents, helping them build capacity to provide developmentally supportive opportunities starting in the NICU and continuing at home. The purpose of this single blinded randomized pilot clinical trial was to evaluate the initial efficacy of SPEEDI to improve early reaching and exploratory problem solving behaviors.

Methods

Fourteen infants born very preterm or with neonatal brain injury were randomly assigned to SPEEDI or Usual Care. The SPEEDI group participated in …


Improving Temporal Accuracy Of Human Metabolic Chambers For Dynamic Metabolic Studies, Shanshan Chen, Erica Wohlers, Eric Ruud, Jon Moon, Bin Ni, Francesco S. Celi Jan 2018

Improving Temporal Accuracy Of Human Metabolic Chambers For Dynamic Metabolic Studies, Shanshan Chen, Erica Wohlers, Eric Ruud, Jon Moon, Bin Ni, Francesco S. Celi

Biostatistics Publications

Metabolic chambers are powerful tools for assessing human energy expenditure, providing flexibility and comfort for the subjects in a near free-living environment. However, the flexibility offered by the large living room size creates challenges in the assessment of dynamic human metabolic signals—such as those generated during high-intensity interval training and short-term involuntary physical activities—with sufficient temporal accuracy. Therefore, this paper presents methods to improve the temporal accuracy of metabolic chambers. The proposed methods include 1) adopting a shortest possible step size, here one minute, to compute the finite derivative terms for the metabolic rate calculation, and 2) applying a robust …


Is Counseling Integral To Buprenorphine-Assisted Opioid Addiction Treatment? Examining Counseling Participation And Treatment Retention At A Richmond, Virginia Clinic, John R. Gyourko, Hilary Colin King Jan 2018

Is Counseling Integral To Buprenorphine-Assisted Opioid Addiction Treatment? Examining Counseling Participation And Treatment Retention At A Richmond, Virginia Clinic, John R. Gyourko, Hilary Colin King

Social Work Student Works

Treatment providers in Virginia are required by law to offer counseling or referrals to all clients receiving medication-assisted opioid use disorder (OUD) treatment (American Society of Addiction Medicine, 2016; Medical Society of Virginia, 2018). Prescribing physicians widely regard counseling as a critical component of medication-assisted OUD treatment (Lin, Lofwall, Walsh, & Knudsen, 2019), and clients perceive counseling to be among the most important factors promoting recovery from opioid dependence (Hay, Huhn, Tompkins, & Dunn, 2019). Research investigating the efficacy of counseling as an OUD treatment component, however, has been equivocal to date (Brown, 2018; Dugosh et al., 2016). The current …


Toward Competitive Employment For Persons With Intellectual And Developmental Disabilities: What Progress Have We Made And Where Do We Need To Go, Paul Wehman, Joshua Taylor, Valerie Brooke, Lauren Avellone, Holly N. Whittenburg, Whitney Ham, Alissa Molinelli Brooke, Staci Carr Jan 2018

Toward Competitive Employment For Persons With Intellectual And Developmental Disabilities: What Progress Have We Made And Where Do We Need To Go, Paul Wehman, Joshua Taylor, Valerie Brooke, Lauren Avellone, Holly N. Whittenburg, Whitney Ham, Alissa Molinelli Brooke, Staci Carr

Physical Medicine and Rehabilitation Publications

Progress toward competitive integrated employment (CIE) for people with intellectual and developmental disabilities (IDD) over the last 40 years has been mixed. Despite evidence showing that supported employment interventions can enable adults with IDD to effectively get and keep jobs, national rates of integrated employment remain below a third of the working-age population. Progress is being made to improve these outcomes. Pathways have been identified that lead to CIE through supported employment, customized employment, internship experiences, and postsecondary education. The recent passage of the Workforce Innovation and Opportunity Act (WIOA) has created fresh momentum and increased the onus on interagency …


The Relationship Between Body Mass Index, Binge Eating Disorder And Suicidality, Kristal Lyn Brown, Jessica Gokee Larose, Briana Mezuk Jan 2018

The Relationship Between Body Mass Index, Binge Eating Disorder And Suicidality, Kristal Lyn Brown, Jessica Gokee Larose, Briana Mezuk

Health Behavior and Policy Publications

Background
While restrictive and compensatory eating disorders (e.g. anorexia and bulimia) are associated with elevated risk of suicide, less is known about binge eating disorder (BED). There is suggestive evidence of a U-shaped relationship between body mass index (BMI) and completed suicide, but fewer studies on suicidal ideation or attempts. This study examined the association between BED, BMI, and suicidality, and assessed whether these relationships varied by gender.

Methods
Data come from the Collaborative Psychiatric Epidemiologic Surveys (N = 14,497). Binge episodes and BED were assessed using the Composite International Diagnostic Inventory (CIDI). BMI was calculated from self-reported height …


Pharmacy Staff Perspectives On Alcohol And Medication Interaction Prevention Among Older Rural Adults, Faika Zanjani, Hannah Allen, Rachel Vickers Smith, Demetra Antimisiaris, Nancy Schoenberg, Catherine Martin, Richard Clayton Jan 2018

Pharmacy Staff Perspectives On Alcohol And Medication Interaction Prevention Among Older Rural Adults, Faika Zanjani, Hannah Allen, Rachel Vickers Smith, Demetra Antimisiaris, Nancy Schoenberg, Catherine Martin, Richard Clayton

Gerontology Publications

Older adults are at high risk for alcohol and medication interactions (AMI). Pharmacies have the potential to act as ideal locations for AMI education, as pharmacy staff play an important role in the community. This study examined the perspectives of pharmacy staff on AMI prevention programming messaging, potential barriers to and facilitators of older adult participation in such programming, and dissemination methods for AMI prevention information. Flyers, telephone calls, and site visits were used to recruit 31 pharmacy staff members who participated in semistructured interviews. A content analysis of interview transcriptions was conducted to identify major themes, categories, and subcategories. …


Improving Resident Understanding Of Healthcare Business And Policy Through The Development Of A High-Yield And Dynamic Educational Series, John Legge Jan 2018

Improving Resident Understanding Of Healthcare Business And Policy Through The Development Of A High-Yield And Dynamic Educational Series, John Legge

Health Sciences Education Symposium

Objective: Residents have a strong desire to be engaged in and learn about the financial and societal impact of health care delivery and reform initiatives1,2. In order to address this need, a Business and Health Policy Educational Series was developed, with positive feedback from participating residents. Background: During the Program Evaluation Committee (PEC) meeting, as part of the annual review of the ACGME education curriculum for the Virginia Commonwealth University Neurology Residency Program, a deficiency was identified with regard to resident self-perception of understanding of the business and policy of healthcare and reform initiatives. This deficiency is one shared at …