Medicine and Health Sciences Commons^™

Determinants Of The New Entry Of Hmos Into A Medicare Risk Contract: A Resource Dependence-Diversification Model, Chih-Wen Pai

Theses and Dissertations

The purpose of this study is to examine the determinants of the new entry of an HMO into a Medicare risk contract using a resource dependence—diversification model. This study is conducted through a non-experimental, panel design With one year time lag. An HMO’s market is defined as the service area. The primary sample for this study is composed of 440 HMOS that do not have a Medicare risk contract as of January 1994.

Data for the variables are extracted from the 1994 and 1995 InterStudy and Group Health Association of America (GHAA) directories, the 1996 Area Resource File, the 1994 …

Physical And Chemical Stability Of Spray Dried Sugars And Protein-Sugar Molecuiar Mixtures For Inhalation, Venkatesh Naini

Theses and Dissertations

The feasibility of producing inhalable microparticles of sugars and protein-sugar molecular mixtures using spray drying was investigated as an alternative to conventional micronization techniques. Four sugars; lactose (L), trehalose (T), sucrose (S) and mannitol (M) were spray dried using a commercial bench-top spray dryer and their physicochemical stability, with respect to particle size, moisture uptake and crystallinity changes, investigated after storage at 23%, 52%, 75% and 93% relative humidity (RH) and 25 °C for 30 days. Two crystalline size fractions (“coarse” = 125-212 μm and “fine” = 44-74 μm) of each sugar, were also characterized, as possible replacements for lactose …

Computer Modeling Of Anatomical Structure: A Representative Example Of Modeling The Inguinal Canal, Jason Michael Highsmith

Theses and Dissertations

As computers become an increasingly important part of medical education, a proper understanding of the techniques and applications of computer aided modeling is vital. An initial overview of medical imaging and the techniques of computer modeling is presented. Construction of three-dimensional models of anatomical structures is then discussed in great detail with specific focus on modeling structures like the inguinal canal. The inguinal canal is one region where computer modeling efforts should be directed because it presents a special challenge. Understanding the walls, borders and layering of the inguinal canal is especially difficult but vital to accurate clinical diagnoses of …

Pharmacokinetics And Pharmacodynamics Of Ethanol In Healthy Volunteers: Effects Of Input-Rate And Degree Of Ethanol Exposure On Subjective And Objective Measures Of Impairment, Vijay A. Ramchandani

Theses and Dissertations

The goal of this project was to investigate the effect of input-rate (oral and intravenous) and degree of exposure on the pharmacokinetics of ethanol and on subjective and objective measures of impairment, as well as on the development of acute tolerance to the effects of ethanol in young, healthy volunteers.

The primary objective of this research was to test the following hypotheses: 1) the rate and degree of ethanol exposure (oral and intravenous) in normal healthy males and females affect the pharrnacokinetics (PK) and pharmacodynarnics (PD) of ethanol in a non-linear fashion; 2) the EEG changes after ethanol administration correlate …

Evaluation Of Cannabinoid Receptor Interaction Of Anandamide, The Endogenous Cannabinoid Receptor Ligand, Irma Bateman Adams

Theses and Dissertations

Recent evidence implicates anandamide as the endogenous ligand for the cannabinoid receptor. One purpose of this study was to determine the structural requirements for anandamide's receptor interaction and the influence of phenylmethylsulfonyl fluoride (PMSF), an enzyme inhibitor, on receptor affinity. A second objective was evaluation of the correlation between affinities of the analogs and in vivo pharmacological activities. The ability of anandamide and analogs to displace [3H]- CP 55,940 was determined by a filtration assay. Displacement curves for anandamide in the presence of PMSF produced a Ki of 89 ± 10 nM; without PMSF the Ki increased to 5400 ± …