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Lack Of Effect Of Induction Of Hypothermia After Acute Brain Injury, Guy L. Clifton, Emmy R. Miller, Sung C. Choi, Harvey S. Levin, Stephen Mccauley, Kenneth R. Smith, J. Paul Muizerlaar, Franklin C. Wagner, Donald W. Marion, Thomas G. Luerssen, Randall M. Chesnut, Michael Schwartz
Lack Of Effect Of Induction Of Hypothermia After Acute Brain Injury, Guy L. Clifton, Emmy R. Miller, Sung C. Choi, Harvey S. Levin, Stephen Mccauley, Kenneth R. Smith, J. Paul Muizerlaar, Franklin C. Wagner, Donald W. Marion, Thomas G. Luerssen, Randall M. Chesnut, Michael Schwartz
Biostatistics Publications
Background
Induction of hypothermia in patients with brain injury was shown to improve outcomes in small clinical studies, but the results were not definitive. To study this issue, we conducted a multicenter trial comparing the effects of hypothermia with those of normothermia in patients with acute brain injury.
Methods
The study subjects were 392 patients 16 to 65 years of age with coma after sustaining closed head injuries who were randomly assigned to be treated with hypothermia (body temperature, 33°C), which was initiated within 6 hours after injury and maintained for 48 hours by means of surface cooling, or normothermia. …