Medicine and Health Sciences Commons^™

Maternal Obesity Is Associated With The Formation Of Small Dense Ldl And Hypoadiponectinemia In The Third Trimester, Barbara J. Meyer, Frances M. Stewart, Elizabeth A. Brown, Josephine Cooney, Solveig Nilsson, Gunilla Olivecrona, Jane E. Ramsay, Bruce A. Griffin, Muriel J. Caslake, Dilys J. Freeman

Faculty of Science, Medicine and Health - Papers: part A

CONTEXT: Maternal obesity is associated with high plasma triglyceride, poor vascular function, and an increased risk for pregnancy complications. In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density lipoprotein (LDL). HYPOTHESIS: In obese pregnancy, increased plasma triglyceride concentrations result in triglyceride enrichment of very low-density lipoprotein-1 particles and formation of small dense LDL via lipoprotein lipase. DESIGN: Women (n = 55) of body mass index of 18-46 kg/m(2) were sampled longitudinally at 12, 26, and 35 weeks' gestation and 4 months postnatally. SETTING: Women were recruited at hospital antenatal appointments, and study visits were in a …

Mouse Strain-Dependent Variation In Obesity And Glucose Homeostasis In Response To High-Fat Feeding, M K. Montgomery, N L. Hallahan, S H. Brown, M Liu, T W. Mitchell, G J. Cooney, N Turner

Illawarra Health and Medical Research Institute

Aims/hypothesis: Metabolic disorders are commonly investigated using knockout and transgenic mouse models. A variety of mouse strains have been used for this purpose. However, mouse strains can differ in their inherent propensities to develop metabolic disease, which may affect the experimental outcomes of metabolic studies. We have investigated strain-dependent differences in the susceptibility to diet-induced obesity and insulin resistance in five commonly used inbred mouse strains (C57BL/6J, 129X1/SvJ, BALB/c, DBA/2 and FVB/N). Methods: Mice were fed either a low-fat or a high-fat diet (HFD) for 8 weeks. Whole-body energy expenditure and body composition were then determined. Tissues were used to …

Segregation Of A Latent High Adiposity Phenotype In Families With A History Of Type 2 Diabetes Mellitus Implicates Rare Obesity-Susceptibility Genetic Variants With Large Effects In Diabetes-Related Obesity, Arthur B. Jenkins, Marijka Batterham, Dorit Samocha-Bonet, Katherine Tonks, Jerry R. Greenfield, Lesley V. Campbell

Faculty of Science, Medicine and Health - Papers: part A

Background We recently reported significantly greater weight gain in non-diabetic healthy subjects with a 1st degree family history (FH+) of type 2 diabetes mellitus (T2DM) than in a matched control group without such history (FH−) during voluntary overfeeding, implying co-inheritance of susceptibilities to T2DM and obesity. We have estimated the extent and mode of inheritance of susceptibility to increased adiposity in FH+.

Methods Normoglycaemic participants were categorised either FH+ (≥1 1st degree relative with T2DM, 50F/30M, age 45±14 (SD) yr) or FH− (71F/51M, age 43±14 yr). Log-transformed anthropometric measurements (height, hip and waist circumferences) and lean, bone and fat mass …

A Proposed Approach To Monitor Private-Sector Policies And Practices Related To Food Environments, Obesity And Non-Communicable Disease Prevention, G Sacks, B Swinburn, V Kraak, S Downs, C Walker, S Barquera, S Friel, C Hawkes, B Kelly, S Kumanyika, M L'Abbe, A Lee, T Lobstein, J Ma, J Macmullan, S Mohan, C Monteiro, B Neal, M Rayner, D Sanders, W Snowdon, S Vandevijvere

Faculty of Science, Medicine and Health - Papers: part A

Private-sector organizations play a critical role in shaping the food environments of individuals and populations. However, there is currently very limited independent monitoring of private-sector actions related to food environments. This paper reviews previous efforts to monitor the private sector in this area, and outlines a proposed approach to monitor private-sector policies and practices related to food environments, and their influence on obesity and non-communicable disease (NCD) prevention. A step-wise approach to data collection is recommended, in which the first ('minimal') step is the collation of publicly available food and nutrition-related policies of selected private-sector organizations. The second ('expanded') step …

Does Food Addiction Heighten The Propensity Towards Obesity In Schizophrenia?, N Pai, S I. Vella

Faculty of Science, Medicine and Health - Papers: part A

Abstract of poster that presented at the 15th ISAM Annual Meeting: Managing Addiction through Evidence-Based Medical and Psychosocial Interventions, 21-23 November 2013, Kuala Lumpur, Malaysia.