Medicine and Health Sciences Commons^™

Frequently Used Antiemetic Agent Dexamethasone Enhances The Metastatic Behaviour Of Select Breast Cancer Cells, Martin Crozier, Janice Tubman, Bre Anne Fifield, Rosa Maria Ferraiuolo, Jenna Ritchie, Katie Zuccato, Emily Mailloux, Indrajit Sinha, Caroline Hamm, Lisa A. Porter

Biomedical Publications

Glucocorticoids, such as dexamethasone (Dex), are used to prevent common side effects induced by chemotherapy and are heavily prescribed for solid cancers such as breast cancer. There is substantial pre-clinical data to support that Dex activation of the glucocorticoid receptor overrides chemotherapy-induced apoptosis in breast cancer cell lines. These findings are compounded by a recent study demonstrating that increased glucocorticoid receptor activation by endogenous stress hormones increased breast cancer heterogeneity and metastasis. Our study is the first to use both in vitro and in vivo models to thoroughly compare the Dex response on the migration of multiple estrogen receptor negative …

Addressing The Barriers To Clinical Trials Accrual In Community Cancer Centres Using A National Clinical Trials Navigator:A Cross-Sectional Analysis, Caroline Hamm, Dora Cavallo-Medved, Devinder Moudgil, Lee Mcgrath, John Huang, Yueyang Li, Tyler W. Stratton, Tyler Robinson, Krista Naccarato, Stephen Sundquist, Janet Dancey

Biomedical Publications

Introduction: Clinical trials, although academically accepted as the most effective treatment available for cancer patients, poor accrual to clinical trials remains a significant problem. A clinical trials navigator (CTN) program was piloted where patients and/or their healthcare professionals could request a search and provide a list of potential cancer clinical trials in which a patient may be eligible based on their current status and disease. Objectives: This study examined the outcomes of a pilot program to try to improve clinical trials accrual with a focus on patients at medium to small sized cancer programs. Outcomes examined included patient disposition (referral …

Wound Management Provided By Advanced Practice Nurses: A Scoping Review Protocol., Sherry Morrell, Gina Pittman, Adam Mulcaster

Nursing Publications

OBJECTIVE: The objective of this review is to examine the current state of the literature regarding wound care provided by advanced practice nurses globally. Specifically, this review will examine the similarities and differences in the wound care practice of advanced practice nurses, including nurse practitioners, clinical nurse specialists, and advanced practice registered nurses.

INTRODUCTION: Advanced practice nurses have graduate education and advanced scope of practice. The addition of advanced wound care training provides unique opportunities for advanced practice nurses to provide wound care.

INCLUSION CRITERIA: This review will consider advanced practice nurses who are nurse practitioners or registered nurses with …

Fitted Filtration Efficiency And Breathability Of 2-Ply Cotton Masks: Identification Of Cotton Consumer Categories Acceptable For Homemade Cloth Mask Construction, Ken G. Drouillard, Amanda Tomkins, Sharon Lackie, Scott Laengert, Allison Baker, Catherine M. Clase, Charles F. De Lannoy, Dora Cavallo-Medved, Lisa A. Porter, Rebecca S. Rudman

Biomedical Publications

The objective of this study was to characterize commercially-available cotton fabrics to determine their suitability as materials for construction of cloth masks for personal and public use to reduce infectious disease spread. The study focused on cottons because of their widespread availability, moderate performance and they are recommended for inclusion in home-made masks by international health authorities. Fifty-two cottons were analyzed by electron microscopy to determine fabric characteristics and fabric weights. Sixteen fabrics were selected to test for breathability and to construct 2-ply cotton masks of a standard design to use in quantitative fit testing on a human participant. Cotton …

35ci Solid-State Nmr Characterization Of Polymorphs And Cocrystals Of Xylazine Hci, Louae M. Abdulla

Electronic Theses and Dissertations

Xylazine HCl (X), a common veterinary analgesic, has four reported polymorphs that are stable under ambient conditions, Form A (Xa), Form X (Xx), Form Z (Xz), and Form M (Xm), and one monohydrate (Xh). A commercial sample of X was found to contain mixtures of polymorphs and previous synthetic approaches proved unreliable and/or unsuccessful for the production of pure phases in high yields. Herein, we report methods for the reliable preparation and interconversion of polymorphs of X (including mechanochemical synthetic pathways), the discovery of a novel polymorph (Xy), and synthesis of three novel cocrystals with coformers containing amide and carboxylic …

Virtual Versus Face-To-Face Cognitive Behavioral Treatment Of Depression: Meta-Analytic Test Of A Noninferiority Hypothesis And Men’S Mental Health Inequities, Carly M. Charron, Kevin M. Gorey

Social Work Publications

Global rates of depression have increased significantly since the beginning of the COVID-19 pandemic. It is unclear how the recent shift of many mental health services to virtual platforms has impacted service users, especially for the male population which are significantly more likely to complete suicide than women. This paper presents the findings of a rapid meta-analytic research synthesis of 17 randomized controlled trials on the relative efficacy of virtual versus traditional face-to-face cognitive behavioral therapy (CBT) in mitigating symptoms of depression. Participants’ aggregated depression scores were compared upon completion of the therapy (posttest) and longest follow-up measurement. The results …

Exploring Bscn Recent Graduates’ Perceived Readiness To Practice, Robyn Marie Lapuz

Electronic Theses and Dissertations

Assessing BScN recent graduates and their readiness to practice is of vital importance in the climate of high nursing turnover and nursing migration. The literature confirms that readiness to practice is a longstanding issue in nursing and the practice-education gap remains an issue to date. The purpose of this research was to explore BScN recent graduates’ perceived readiness to practice in nursing and make recommendations for nursing practice, education, and future research. A cross-sectional descriptive correlational mixed-methods research design was used for this research. The results confirm that the majority of BScN recent graduates from this study reported feeling ready …

The Experience Of Transitioning For The Transgender Person: An Appreciative Inquiry Approach To Advance Gender Affirming Care, Shelley Evans

Electronic Theses and Dissertations

Background. The process of transitioning has a significant impact on improving quality of life among transgender and nonbinary people (Johansson et al., 2010). Transitioning is the act of moving towards a gender identity that feels more aligned with internal identity (Rankin & Beemyn, 2012). However, despite promising research that supports the benefits of medical, social and/or legal transitioning, the understanding of the experience has not been fully explored (Evans et al., 2021), and it is a barrier to advancing the delivery of gender affirming care among nurses, other health care providers, and health care organizations. There is a need to …

Studies Of Chemosensory Responses In The Pharynx Of The Sea Lamprey (Petromyzon Marinus), Hasan Huseyin Polat

Electronic Theses and Dissertations

The sea lamprey is a basal vertebrate, and the oldest extant species with taste buds. The objective of this thesis was to study the chemosensory responses from the sea lamprey’s pharynx, which is located caudal to oral cavity and medial to seven lateral brachiopores. The pharynx contains taste buds that detect and respond to tastants to inform lampreys about gustatory factors in the environment. The location of these taste buds along the lateral surface of the pharynx was first determined using scanning electron microscopy. Then using electrophysiology, our recordings from these pharyngeal regions containing taste buds picked up responses from …

A Kinematic Analysis Of Joint Angle And Center Of Mass Kinematics In Automotive Manufacturing Tasks, Jarrod Smith

Electronic Theses and Dissertations

This research aimed to determine if participants of varying anthropometrics (i.e., height) would perform automotive manufacturing tasks significantly differently based on joint angle and center of mass (COM) data. Twenty-four participants between the ages of 18 and 65 (¯x = 24.1 years, SD = 7.3) completed 14 manufacturing tasks, and their motions were recorded using two inertial motion capture (IMC) systems. Participants were chosen based on their measured height, including the 5th percentile female (Group 1-5F), 50th percentile female (Group 2-50F), or 95th percentile male (Group 3-95M) (Fryar, Gu, Ogden & Flegal, 2016). The tasks used for this study were …