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Articles 1 - 9 of 9
Full-Text Articles in Medicine and Health Sciences
The Role Of The Circadian Clock In The Intestinal Epithelium During Health, Regeneration, And Tumourigenesis, Kyle Stokes
The Role Of The Circadian Clock In The Intestinal Epithelium During Health, Regeneration, And Tumourigenesis, Kyle Stokes
Electronic Theses and Dissertations
The Earth’s axial rotation subjects its surface to constant periods of light and dark, this is known as photoperiod. Many organisms have adapted their physiology in accordance with this environmental constant by generating 24h rhythms in their physiological functions; these are known as circadian rhythms. Circadian rhythms are controlled by an endogenous time-keeping mechanism known as the circadian clock. Over 40% of the genome in mice and over 80% of the genome in primates has been shown to have 24h rhythms in transcription. The disruption of circadian rhythms through shiftwork, jetlag, or exposure to light at night is associated with …
Physiological State Determinants Of Maternal Cortisol Signaling And Its Impact On Offspring Quality And Fitness, Sydney Currier
Physiological State Determinants Of Maternal Cortisol Signaling And Its Impact On Offspring Quality And Fitness, Sydney Currier
Electronic Theses and Dissertations
Assessing the intergenerational effects of maternal stress is important for predicting how offspring will respond to changing environments. The overall aim of my thesis was to quantify the effects of maternal state on maternally derived egg cortisol and determine whether this variation in egg cortisol impacts Chinook salmon offspring performance and fitness in a sex-specific way. I quantified within-female changes in maternal energetics and reproductive metrics that I linked to egg quality and ultimately embryo survival. I found egg cortisol increases with increasing maternal plasma cortisol, and increases further as plasma cortisol levels rise with each day that eggs are …
Exploring The Role Of Nkr-P1b:Clr-B Interaction In Mouse Mammary Tumour Immunosurveillance, Raghd Al Olabi
Exploring The Role Of Nkr-P1b:Clr-B Interaction In Mouse Mammary Tumour Immunosurveillance, Raghd Al Olabi
Electronic Theses and Dissertations
Natural killer (NK) cells are large, granular, and cytotoxic innate lymphocytes which do not require prior antigenic exposure to target cancerous and virally infected cells. NK cells possess activating and inhibitory receptors which may activate or inhibit NK cell activity, respectively. In mice, the inhibitory NKR-P1B receptor on NK cells recognizes the C-type lectin-related protein-b (Clr-b) ligand expressed on most autologous cells but downregulated on many tumour cell lines. In B cell lymphoma models, the disruption of NKR-P1B:Clr-b interaction results in delayed tumour development and progression, suggesting that blockage of inhibitory signals from NKR-P1B augments NK cell activity against lymphoma …
The Effects Of Acute Hyperthermia On The Neurovascular Unit, Brooke Renee Shepley
The Effects Of Acute Hyperthermia On The Neurovascular Unit, Brooke Renee Shepley
Electronic Theses and Dissertations
With growing use for hyperthermia as a cardiovascular therapeutic, there is surprisingly little information regarding the acute effects it may have on the integrity of the neurovascular unit (NVU). Indeed, relying on animal data would suggest hyperthermia comparable to levels attained in thermal therapy will disrupt the blood- brain barrier (BBB) and damage the cerebral parenchymal cells. We sought to address the hypothesis that controlled passive hyperthermia is not sufficient to damage the NVU in healthy adults. Eleven young men (age 23 ± 3 years) underwent acute passive heating until +2°C or absolute esophageal temperature of 39.5°C. The presence of …
The Role Of The Nkr-P1b:Clr-B Inhibitory Axis In Nk Cell-Mediated Tumour Immunosurveillance, Abd El Aziz Hendy
The Role Of The Nkr-P1b:Clr-B Inhibitory Axis In Nk Cell-Mediated Tumour Immunosurveillance, Abd El Aziz Hendy
Electronic Theses and Dissertations
Natural killer (NK) cells are lymphocytes of the innate immune system which do not require prior priming to target infected or altered-self cells, such as tumour cells. The basic functions of NK cells include cytotoxicity and cytokine production. These cells possess numerous activating and inhibitory receptors which regulate their function based on a signalling balance. In mice, NK cells possess NKR-P1B inhibitory receptors which recognize the C-type lectin-related protein-b (Clr-b) ligand. This ligand is present on healthy self cells and may be used by cancer cells to evade NK cell effector functions. The disruption of the NKR-P1B:Clr-b axis has been …
An Enhancement To Cnn Approach With Synthesized Image Data For Disease Subtype Classification, Narider Pal Singh
An Enhancement To Cnn Approach With Synthesized Image Data For Disease Subtype Classification, Narider Pal Singh
Electronic Theses and Dissertations
The introduction of genetic testing has profoundly enhanced the prospects of early detection of diseases and techniques to suggest precision medicines. The subtyping of critical diseases has proven to be an essential part of the development of individualized therapies and has led to deeper insights into the heterogeneity of the disease. Studies suggest that variants in particular genes have significant effects on certain types of immune system cells and are also involved in the risk of certain critical illnesses like cancer. By analyzing the genetic sequence of a patient, disease types and subtypes can be predicted. Recent research work has …
A Program Evaluation Of Nutrition-Based Educational Modules Designed For The University Of Windsor Lancers Varsity Athletics, Justine Van Herk
A Program Evaluation Of Nutrition-Based Educational Modules Designed For The University Of Windsor Lancers Varsity Athletics, Justine Van Herk
Electronic Theses and Dissertations
The purpose of this program evaluation was to develop nutrition-based educational modules for the coaches and student-athletes at the University of Windsor and to investigate their effectiveness, usefulness, and applicability. The nutrition-based educational modules were a collaborative effort between the Community Health, Environment, and Wellness (CHEW) lab and the Centre for Human Performance and Health (CHPH). Eight teams voluntarily participated in the 6-week implementation period with the nutrition-based educational modules. Following this implementation period, nine participants (n = 2 coaches, n = 7 student-athletes) volunteered to provide feedback during one-on-one semi-structured virtual interviews. The interview guide was divided into …
Nurse Practitioner Opioid Prescribing And Safety Measure Utilization Patterns In Ontario: An Explanatory Sequential Mixed Methods Study, Gina Pittman
Electronic Theses and Dissertations
Background. There has been a rise in opioid-related hospitalizations, emergency department visits, and mortality due to opioid poisoning across Canada. There is a gap in research related to Nurse practitioner (NP) opioid prescribing and safety measure utilization patterns and sparse literature related to physician opioid prescribing (Pittman et al., 2020). Purpose. A mixed methods approach, specifically an explanatory sequential three-phase study, was undertaken to explore this topic. The initial phase was development of the quantitative survey, followed by collection and analysis of the quantitative data. A final qualitative phase added insight into the quantitative results. There were four objectives for …
A Network-Based Approach For Computational Drug Repurposing On Cancer Data, Ann Reba Thomas Alexander
A Network-Based Approach For Computational Drug Repurposing On Cancer Data, Ann Reba Thomas Alexander
Electronic Theses and Dissertations
In this thesis, we are interested in finding the best drugs that can be repurposed for the disease and able to find the adverse effects such drugs that are FDA-Approved. Developing an effective drug can be a time-consuming and expensive crucible method. Network-based machine learning methods are used for predicting a given drug for A that can be used for B. It aims at finding new indications for already existing drugs and therefore increases the available therapeutic choices at a fraction of the cost of new drug development. The perturbation gene expression data corresponding to the MCF7 cell line was …