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- Health and Kinesiology Faculty Publications and Presentations (3)
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Articles 1 - 11 of 11
Full-Text Articles in Medicine and Health Sciences
Transcription Factor Runx3 Is Induced By Influenza A Virus And Double-Strand Rna And Mediates Airway Epithelial Cell Apoptosis, Huachen Gan, Qin Hao, Steven Idell, Hua Tang
Transcription Factor Runx3 Is Induced By Influenza A Virus And Double-Strand Rna And Mediates Airway Epithelial Cell Apoptosis, Huachen Gan, Qin Hao, Steven Idell, Hua Tang
School of Medicine Faculty Publications and Presentations
Influenza A virus (IAV) targets airway epithelial cells and exploits the host cell machinery to replicate, causing respiratory illness in annual epidemics and pandemics of variable severity. The high rate of antigenic drift (viral mutation) and the putative antigenic shift (reassortant strains) have raised the need to find the host cell inducible factors modulating IAV replication and its pathogenesis to develop more effective antiviral treatment. In this study, we found for the first time that transcription factor Runx3, a developmental regulator and tumor suppressor, was induced by IAV H1N1 and H3N2, viral RNA, a synthetic analog of viral double-stranded RNA …
Effects Of Light On Riboflavin And Ascorbic Acid In Freshly Expressed Human Milk, Jimi Francis, Darby Dickton
Effects Of Light On Riboflavin And Ascorbic Acid In Freshly Expressed Human Milk, Jimi Francis, Darby Dickton
Health and Kinesiology Faculty Publications and Presentations
Millions of dollars each year is spent funding dairy research to better understand every aspect of milk processing, storage, handling, and shelf life. The dairy industry has shown that in animal milks vitamin C is photo-oxidized when exposed to light, which can cause a cascade of other nutrients that may be affected. Expressed human breast milk has had limited research published, mainly recommendations for storage duration secondary to bacterial growth, with scant research on nutrient quality during handling compared to the animal models. In this study, freshly expressed human milk was placed in containers of varying color/UV sensitivity and exposed …
College Undergraduate Students’ Self-Rating Of Their Physical Activity Involvement Over A 7-Day Period, Wycliffe W. Njororai Simiyu, Fletcher J. Njororai
College Undergraduate Students’ Self-Rating Of Their Physical Activity Involvement Over A 7-Day Period, Wycliffe W. Njororai Simiyu, Fletcher J. Njororai
Health and Kinesiology Faculty Publications and Presentations
Purpose: To establish the college undergraduate students’ self-rated physical activity involvement over a 7-day period. Methodology: The study utilized the survey method using the International Physical Activity Short Version of the Questionnaire (IPAQ). The purpose of the questionnaires is to provide a common instrument that can be used to obtain internationally comparable data on health-related physical activity. The study was undertaken at a medium sized campus in the South Western part of U.S.A., with respondents drawn from the College of Nursing and Health Sciences. Results: A total of 220 students responded to the questionnaire. Most of the respondents, 182 (82.73%) …
Health Literacy Impact On National Healthcare Utilization And Expenditure, Rafia S. Rasu, Walter Agbor Bawa, Richard Suminski, Kathleen Snella, Bradley Warady
Health Literacy Impact On National Healthcare Utilization And Expenditure, Rafia S. Rasu, Walter Agbor Bawa, Richard Suminski, Kathleen Snella, Bradley Warady
Pharmacy Faculty Publications and Presentations
Background: Health literacy presents an enormous challenge in the delivery of effective healthcare and quality outcomes. We evaluated the impact of low health literacy (LHL) on healthcare utilization and healthcare expenditure. Methods: Database analysis used Medical Expenditure Panel Survey (MEPS) from 2005-2008 which provides nationally representative estimates of healthcare utilization and expenditure. Health literacy scores (HLSs) were calculated based on a validated, predictive model and were scored according to the National Assessment of Adult Literacy (NAAL). HLS ranged from 0-500. Health literacy level (HLL) and categorized in 2 groups: Below basic or basic (HLS <226) and above basic (HLS ≥226). Healthcare utilization expressed as a physician, nonphysician, or emergency room (ER) visits and healthcare spending. Expenditures were adjusted to 2010 rates using the Consumer Price Index (CPI). A P value of 0.05 or less was the criterion for statistical significance in all analyses. Multivariate regression models assessed the impact of the predicted HLLs on outpatient healthcare utilization and expenditures. All analyses were performed with SAS and STATA® 11.0 statistical software. Results: The study evaluated 22 599 samples representing 503 374 648 weighted individuals nationally from 2005- 2008. The cohort had an average age of 49 years and included more females (57%). Caucasian were the predominant racial ethnic group (83%) and 37% of the cohort were from the South region of the United States of America. The proportion of the cohort with basic or below basic health literacy was 22.4%. Annual predicted values of physician visits, nonphysician visits, and ER visits were 6.6, 4.8, and 0.2, respectively, for basic or below basic compared to 4.4, 2.6, and 0.1 for above basic. Predicted values of office and ER visits expenditures were $1284 and $151, respectively, for basic or below basic and $719 and $100 for above basic (P<.05). The extrapolated national estimates show that the annual costs for prescription alone for adults with LHL possibly associated with basic and below basic health literacy could potentially reach about $172 billion. Conclusion: Health literacy is inversely associated with healthcare utilization and expenditure. Individuals with below basic or basic HLL have greater healthcare utilization and expenditures spending more on prescriptions compared to individuals with above basic HLL. Public health strategies promoting appropriate education among individuals with LHL may help to improve health outcomes and reduce unnecessary healthcare visits and costs.
Faculty Experience Of Flipping The Classroom: Lessons Learned, Melinda Hermanns, Jerri L. Post, Belinda Deal
Faculty Experience Of Flipping The Classroom: Lessons Learned, Melinda Hermanns, Jerri L. Post, Belinda Deal
Nursing Faculty Publications and Presentations
"Flipping the classroom" is gaining in popularity. The flipped classroom permits active learning and student engagement whereby the traditional class time is transformed into an active learning experience in which students can apply knowledge and interact with their peers and perform "hands-on" activities. This descriptive phenomenological study focused on the lived experiences of nursing faculty implementing a flipped classroom into the medical/surgical curriculum. The faculty's experience with implementing and adapting to non-traditional teaching learning methods of the "flipped"classroom in their medical/surgical classes is shared. The themes expressed by faculty are presented in the two overall categories of: Faculty concerns and …
Genes Regulating Epithelial Polarity Are Critical Suppressors Of Esophageal Oncogenesis, Xiu-Min Li, Hui Wang, Li-Li Zhu, Run-Zhen Zhao, Hong-Long Ji
Genes Regulating Epithelial Polarity Are Critical Suppressors Of Esophageal Oncogenesis, Xiu-Min Li, Hui Wang, Li-Li Zhu, Run-Zhen Zhao, Hong-Long Ji
Cellular and Molecular Biology Faculty Publications and Presentations
Esophageal cancer is an aggressive disease featured by early lymphatic and hematogenous dissemination, and is the sixth leading cause of cancer-related deaths worldwide. The proper formation of apicobasal polarity is essential for normal epithelium physiology and tissue homeostasis, while loss of polarity is a hallmark of cancer development including esophageal oncogenesis. In this review, we summarized the stages of esophageal cancer development associated with the loss or deregulation of epithelial cell apicobasal polarity. Loss of epithelial apicobasal polarity exerts an indispensable role in the initiation of esophageal oncogenesis, tumor progression, and the advancement of tumors from benign to malignant. In …
Successful Strategies For Recruiting Minority Participants In Clinical Research, Danice B. Greer
Successful Strategies For Recruiting Minority Participants In Clinical Research, Danice B. Greer
Nursing Faculty Publications and Presentations
This presentation discusses the history of and successful strategies for recruiting minorities in participating in clinical research.
Walkable Scores For Selected Three East Texas Counties: Physical Activity And Policy Implications, Wycliffe W. Njororai Simiyu, Fletcher J. Njororai, Billystrom Aronya Jivetti
Walkable Scores For Selected Three East Texas Counties: Physical Activity And Policy Implications, Wycliffe W. Njororai Simiyu, Fletcher J. Njororai, Billystrom Aronya Jivetti
Health and Kinesiology Faculty Publications and Presentations
Introduction: Physical activity has become an important intervention against overweight and obesity cases in the USA and worldwide. One key aspect of physical activity is walking, which has been identified as a component that can easily be incorporated into one’s lifestyle. Recent studies on physical activity have focused on promoting walking as a health enhancing endeavor. In 2010, the proportion of Texas adults who reported no participation in leisure time activity (26.7%) was significantly higher than the national average (24.4%). However, many Texans, like most Americans, are sedentary. Purpose: This study examined the walkability of the environments in selected counties …
Binding Of Cxcl8/Il-8 To Mycobacterium Tuberculosis Modulates The Innate Immune Response, Agnieszka Krupa, Marek Fol, Bozena R. Dziadek, Ewa Kepka, Dominika Wojciechowska, Anna Brzostek, Agnieszka Torzewska, Jaroslaw Dziadek, Robert P. Baughman, David Griffith, Anna K. Kurdowska
Binding Of Cxcl8/Il-8 To Mycobacterium Tuberculosis Modulates The Innate Immune Response, Agnieszka Krupa, Marek Fol, Bozena R. Dziadek, Ewa Kepka, Dominika Wojciechowska, Anna Brzostek, Agnieszka Torzewska, Jaroslaw Dziadek, Robert P. Baughman, David Griffith, Anna K. Kurdowska
Cellular and Molecular Biology Faculty Publications and Presentations
Interleukin-8 (IL-8) has been implicated in the pathogenesis of several human respiratory diseases, including tuberculosis (TB). Importantly and in direct relevance to the objectives of this report quite a few findings suggest that the presence of IL-8 may be beneficial for the host. IL-8 may aid with mounting an adequate response during infection with Mycobacterium tuberculosis (M. tb); however, the underlying mechanism remains largely unknown. The major goal of our study was to investigate the contribution of IL-8 to the inflammatory processes that are typically elicited in patients with TB. We have shown for the first time that IL-8 can …
Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali
Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali
Technology Faculty Publications and Presentations
The dry powder inhaler (DPI) is a popular, effective and convenient drug delivery device for inhalation therapy to treat asthma. However, a large quantity (approximately 54%) of inhaled aerosols deposit in the oropharyngeal region. Deposition in this region is undesirable because it provides minimum therapeutic benefits and has adverse localized or systemic side effects. This study reports a method of examining electrostatic charge effects on deposition of three DPI aerosols (Spiriva™ Handihaler, Advair Diskus™, and Pulmicort™ Turbohaler) in a cadaver-based cast of the human oral-pharyngeal-laryngeal (OPL) regions. Experimental aerosols were generated from the three commercially available …
Pharmacologic Activities Of 3’-Hydroxypterostilbene: Cytotoxic, Anti- Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase And Sirtuin 1 Inhibitory Activity, Jody K. Takemoto, Connie M. Remsberg, Neal M. Davies
Pharmacologic Activities Of 3’-Hydroxypterostilbene: Cytotoxic, Anti- Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase And Sirtuin 1 Inhibitory Activity, Jody K. Takemoto, Connie M. Remsberg, Neal M. Davies
Pharmacy Faculty Publications and Presentations
Purpose: Delineate the selected pharmacodynamics of a naturally occurring stilbene 3’- Hydroxypterostilbene. Objective: Characterize for the first time the pharmacodynamics bioactivity in several in-vitro assays with relevant roles in heart disease, inflammation, cancer, and diabetes etiology and pathophysiology. Methods: 3’-Hydroxypterostilbene was studied in in-vitro assays to identify possible bioactivity. Results: 3’-Hydroxypterostilbene demonstrated anti-oxidant, anti-inflammatory, cytotoxic, antiadipogenic, histone deacetylase, and sirtuin-1 inhibitory activity. Conclusions: The importance of understanding individual stilbene pharmacologic activities were delineated. Small changes in chemical structure of stilbene compounds result in significant pharmacodynamic differences.