Medicine and Health Sciences Commons^™

Genetic Control Of Eye Development, A Case Study Focused On The Murine Mutation Belly Spot And Tail (Bst), Qing Tang

Theses and Dissertations (ETD)

Development of the eye is controlled by a network of genes, often conserved, that regulate the timing and location of cellular differentiation. One approach to understanding this network of genes and their interaction is to focus on mutations, spontaneous or induced, that predictably disrupt the proper function of such networks, and by examining the effect of such disruption on the function of other genes.

The Belly spot and tail (Bst) semi-dominant mutation, mapped to mouse Chromosome 16, leads to developmental defects of the eye, skeleton, and coat pigmentation. In the eye, the mutant phenotype is characterized by the presence of …

Portal Imaging Using A Csi (Tl) Scintillator Coupled To A Cooled Ccd Camera, Amit Sawant

Theses and Dissertations (ETD)

The purpose of this research was to design a high performance digital portal imaging
system, using a transparent x-ray scintillator coupled to a cooled CCD camera. Theoretical
analysis using Monte Carlo simulation was performed to calculate the QDE, SNR and DQE of
the system. A prototype electronic portal imaging device (EPID) was built, using a 12.7 mm
thick, 20.32 cm diameter, CsI (Tl) scintillator, coupled to an Astromed ® liquid nitrogen cooled
CCD TV camera. The system geometry of the prototype EPID was optimized to achieve high
spatial resolution. Experimental evaluation of the prototype EPID was performed, by
determining its …

Characterizing Erythrocyte Motions In Flowing Blood, Markos Leggas

Theses and Dissertations (ETD)

Characterizing the probabilistic motions of cells is a prerequisite for the development of a general model of transport and surface deposition of white cells and platelets (WBC/P). These phenomena differ greatly when red blood cells (RBC) are present at normal levels, but follow convective diffusion in dilute suspensions. A critical need is to understand and characterize dispersion and diffusion as they apply to red cells in suspension flow. The dispersive motions of
0.5-micrometer beads and fluorescently labeled human RBC flowing in dilute (0.003%) and concentrated (25%) RBC suspensions, respectively, were characterized using fluorescence videomicroscopy methods, and times for individual tracer …

Late Effects Of Ionizing Radiation On Normal Microvascular Networks, Vinh Nguyen

Theses and Dissertations (ETD)

Therapeutic doses of ionizing radiation result in changes in the structure and function of microvascular networks in normal tissue. Previously, we reported on the early effects of ionizing radiation on microvascular networks at 3, 7, and 30 days post-irradiation [1-3]. Data from the early time points suggested that ionizing radiation significantly alters the structure and function of microvascular networks and interferes with the normal processes of vessel maturation. Here, we
present our findings on the late effects of ionizing radiation on normal tissue microvasculature at 60, 120, and 180 days post-irradiation. The cremaster muscle of Golden Syrian hamster was locally …