Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medical Sciences (2)
- Alternative and Complementary Medicine (1)
- Biochemical Phenomena, Metabolism, and Nutrition (1)
- Biochemical and Biomolecular Engineering (1)
- Cancer Biology (1)
-
- Cell and Developmental Biology (1)
- Chemical Engineering (1)
- Chemical and Pharmacologic Phenomena (1)
- Diseases (1)
- Engineering (1)
- Life Sciences (1)
- Medical Nutrition (1)
- Molecular, Genetic, and Biochemical Nutrition (1)
- Nanomedicine (1)
- Nanotechnology (1)
- Nutrition (1)
- Nutritional and Metabolic Diseases (1)
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Pkm2 Influences The Metabolic Fate Of Butyrate In Colorectal Cancer Cells, Megan Louise Pence
Pkm2 Influences The Metabolic Fate Of Butyrate In Colorectal Cancer Cells, Megan Louise Pence
Chancellor’s Honors Program Projects
No abstract provided.
Elucidating The Effects Of Metabolic State On Nanoparticle Distribution In Mice And In Vitro Uptake, Kevin James Quigley
Elucidating The Effects Of Metabolic State On Nanoparticle Distribution In Mice And In Vitro Uptake, Kevin James Quigley
Doctoral Dissertations
Since almost 70% of the U.S. population over 20 years old is overweight and 30% is obese, with much of the western world following suit, many patients that will potentially be administered circulating nanoparticles designed to localize to tumors and avoid non-target areas will have significant amounts of white adipose tissue (WAT), enlarged livers, and additional metabolic complications such as type 2 diabetes. However, studies on nanoparticle biodistribution and efficacy take place almost without exception in lean rodents with healthy metabolic states. In this work, I determined the biodistribution of model nanoparticles – neutral filomicelles and polystyrene spheres both carrying …
Identification Of Novel Molecular Targets Of Resveratrol In Colorectal Carcinogenesis, Nichelle Chantil Whitlock
Identification Of Novel Molecular Targets Of Resveratrol In Colorectal Carcinogenesis, Nichelle Chantil Whitlock
Doctoral Dissertations
Current research suggests resveratrol, a phytoalexin found predominately in grapes, may function as a chemopreventive and/or chemotherapeutic agent for various cancers, including colorectal cancer. However, the underlying mechanism(s) involved in these activities remain elusive. Thus, the objective of the studies discussed here sought to investigate the effect of resveratrol treatment on gene modulation in human colorectal cancer cells in order to identify and characterize novel molecular targets that contribute to the observed anticancer activities of resveratrol. Here, we identify activating transcription factor 3 (ATF3) and early growth response-1 (Egr-1) as novel targets of resveratrol and provide data to elucidate the …