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Full-Text Articles in Medicine and Health Sciences
Role Of Chronic Inflammation On Liver Function During Cachexia Progression In The ApcMin/+ Mouse Model, Aditi Narsale
Role Of Chronic Inflammation On Liver Function During Cachexia Progression In The ApcMin/+ Mouse Model, Aditi Narsale
Theses and Dissertations
Cachexia is a multifactorial syndrome that manifests during the advanced stage of chronic diseases and is characterized by a progressive loss of body mass sustained by underlying inflammation. The ApcMin/+ mouse is an established model of cachexia that exhibits a gradual loss of body mass correlating with increasing tumor burden and plasma IL – 6 levels. Moreover it also mimics other secondary characteristics observed in cachectic patients like splenomegaly, elevated plasma endotoxin levels, gut barrier dysfunction, hypogonadism and an overall hypermetabolic state. Liver controls the energy metabolism in the body by regulating glucose and lipid metabolism, glycogen storage, filtration of …
The Regulation Of Skeletal Muscle Mass And Mitochondrial Biogenesis By Gp130/Stat3 Signaling During Cancer Cachexia, Melissa Puppa
The Regulation Of Skeletal Muscle Mass And Mitochondrial Biogenesis By Gp130/Stat3 Signaling During Cancer Cachexia, Melissa Puppa
Theses and Dissertations
Cachexia affects nearly 70% of all cancer patients depending on the cancer, and decreases cancer survival. Cachexia is associated with muscle mass loss that is accompanied by a loss in muscle oxidative capacity, a decrease in protein synthesis and an increase in protein degradation. While progress has been made in understanding some of the mechanisms underlying the cachectic condition, there are currently no approved pharmaceutical interventions to slow or stop cachexia progression. The purpose this study was to determine the role of skeletal muscle gp130 and STAT3 signaling in the regulation of cachexia induced muscle atrophy and mitochondrial loss. Specific …