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Efficacy Of Combined 5-Fluorouracil And Photodynamic Therapy In Glioma Spheroids, Karanjit Singh
Efficacy Of Combined 5-Fluorouracil And Photodynamic Therapy In Glioma Spheroids, Karanjit Singh
UNLV Theses, Dissertations, Professional Papers, and Capstones
Standard treatment regimens consisting of surgery, radiation and chemotherapy have proven ineffective for the treatment of high-grade gliomas such as glioblastoma multiforme (GBM). An effective cure requires elimination of nests of tumor cells that have migrated from the resection margin and infiltrated normal brain. A number of localized therapies, including light-based approaches such as photodynamic therapy (PDT) and photochemical internalization (PCI) are currently under investigation for the management of GBM patients.
Several studies have demonstrated a high degree of synergy between PDT and bleomycin, via the PCI mechanism, in a variety of in vitro and in vivo models, including glioma …