Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Impact Of Time-Varying And Time-Invariant Measures Of Adherence To Secondary Prevention Therapies Post-Acute Myocardial Infarction: An Application Of Marginal Structural Models (Msms), Tasneem Taher Lokhandwala
Impact Of Time-Varying And Time-Invariant Measures Of Adherence To Secondary Prevention Therapies Post-Acute Myocardial Infarction: An Application Of Marginal Structural Models (Msms), Tasneem Taher Lokhandwala
Electronic Theses and Dissertations
The purpose of the study was to explore the relationship between patient adherence to secondary prevention therapies post an initial episode of acute myocardial infarction (AMI) and subsequent risk of cardiovascular events by using time-invariant and time-varying measures of adherence. The effectiveness of both measures in predicting a (i) recurrent AMI, and (ii) mortality using various mathematical models and statistical techniques was compared. Time dependent confounding was accounted for by using marginal structural models (MSMs). A longitudinal cohort observational study design was employed using the retrospective Medicare 5% random national sample claims data from January 1st, 2006 to December 31st, …