Medicine and Health Sciences Commons^™

Ethical Issues In Graduate Research, William J. Frey

Ethics in Science and Engineering National Clearinghouse

(Caution! This module is being published in an incomplete, preliminary version. Later edited and fuller versions will follow.) "Graduate Education in Research Ethics for Scientists and Engineers" is a project funded by the National Science Foundation (SES 0629377) to design a pilot program in research ethics for graduate students in science and engineering. This project is built around three workshops: (1) a Graduate Awareness Workshop introduces students to fundamental ethical issues in research, (2) a Moral Deliberation Workshop acquaints students with the skills of moral deliberation, (3) a Case Analysis Workshop uses realistic scenarios to allow students to practice decision-making …

Effects Of Sex And Social Status On Neuromuscular Differentiation In The Eusocial Naked Mole-Rat (Heterocephalus Glaber), Marianne Louise Seney

Open Access Dissertations

Naked mole-rats live in large colonies and exhibit a strict reproductive hierarchy. Each colony has 1 breeding female and 1-3 breeding males; all other individuals are non-reproductive subordinates. Subordinates show a remarkable lack of sex differences in behavior and anatomy, but can become reproductive if removed from the colony. The striated perineal muscles and their innervating motoneurons, which are sexually dimorphic in all other mammals examined, are not dimorphic in subordinate naked mole-rats. Here I asked whether sexual differentiation of this neuromuscular system occurs when subordinates become breeders. Sex differences in perineal motoneurons were not observed, regardless of social status. …

Molecular Changes Following Skeletal Muscle Disuse In Humans, Kimberly A. Reich

Open Access Dissertations

The purpose of this dissertation was to investigate the molecular events associated with the onset of skeletal muscle disuse in humans. Study I examined global gene expression changes in vastus lateralis muscle following 48h unloading (UL) and 24h reloading (RL) in humans. Results showed that functions related to protein degradation and oxidative stress were enriched following UL and that these global gene expression patterns were not readily reversed following RL, thus indicating that molecular events associated with short-term disuse may persist beyond the duration of the stimulus. In contrast to previous work in IM, collagen gene expression increased in this …

Professional Ethics-Responsible Conduct Of Research Training: Making Sense Of Complex Problems, Michael D. Mumford, Shane Connelly, Ryan P. Brown, Lynn D. Devenport, Stephen T. Murphy, Alison L. Antes

Ethics in Science and Engineering National Clearinghouse

General Course Abstract

This two-day seminar format course exposes students to the complexities involved in real-world ethical decision-making. It provides students with strategies, or tools, for understanding and thinking through ethical problems to arrive at a decision. Students practice working with these strategies by applying them to realistic, complex cases.

Day 1 Abstract

During the first day of the course, guidelines and principles for ethical research practices are discussed. It is emphasized that students must apply guidelines in a context to arrive at a decision, and the course provides guidance on this decision-making process. Next, students learn about the personal …

Federal Register: National Science Foundation, Responsible Conduct Of Research, National Science Foundation

Ethics in Science and Engineering National Clearinghouse

The National Science Foundation (NSF) is announcing its implementation of Section 7009 of the America Creating Opportunities to Meaningfully Promote Excellence in Technology, Education, and Science (COMPETES) Act (42 U.S.C. 1862o–1). This section of the Act requires that ‘‘each institution that applies for financial assistance from the Foundation for science and engineering research or education describe in its grant proposal a plan to provide appropriate training and oversight in the responsible and ethical conduct of research to undergraduate students, graduate students, and postdoctoral researchers participating in the proposed research project.’’

[Abstract by author]

Enduring Influences Of Peripubertal/Adolescent Stressors On Behavioral Response To Estradiol And Progesterone In Adult Female Mice, Julie Laroche, Lauren Gasbarro, James P. Herman, Jeffrey D. Blaustein

Jeffrey D. Blaustein

Exposure to stressors during particular stages of development leads to acute and long-term physiological and behavioral changes. We have reported that shipping mice during the peripubertal/adolescent period results in decreased induction of feminine sexual behavior by estradiol and progesterone in adult female mice. To study further the factors involved in this decreased behavioral response, female mice were exposed to a variety of experimental stressors when 6 wk old. Effects of peripubertal/adolescent exposure to these stressors on acute plasma corticosterone levels and changes in body weight and adult behavioral response to estradiol and progesterone were assessed. Although restraint for three daily …

Dietary Intakes Of Α-Linolenic And Linoleic Acids Are Inversely Associated With Serum C-Reactive Protein Levels Among Japanese Men, Kalpana Poudel-Tandukar, Akiko Nanri, Yumi Matsushita, Satoshi Sasaki, Masanori Ohta, Masao Sato, Tetsuya Mizoue

Elaine Marieb College of Nursing Faculty Publication Series

Investigations suggest a protective role of n-3 polyunsaturated fatty acids (PUFA) but opposing roles of n-6 PUFA in inflammation, but the effects in vivo the human are not clear. We therefore tested the hypothesis that higher intakes of n-3 PUFA and n-6 PUFA are associated with lower levels of inflammation among a population consuming a diet high in PUFA. This study aimed to assess theassociation between PUFA intake and serum C-reactive protein (CRP) concentrations in a group of Japanese employees. The study subjects were 300 men and 211 women aged 21 to 67 years workingin 2 municipal offices of Japan. …

Feasibility Of Family Participation In A Delirium Prevention Program For The Older Hospitalized Adult, Deborah Rosenbloom-Brunton

Open Access Dissertations

Objective . To examine the feasibility of family participation in a nurse-supported, multicomponent intervention program for delirium prevention in the older hospitalized adult. Background . Delirium is the leading complication of hospitalization for older adults and is associated with important consequences including increased morbidity and mortality, increased use of health care resources, and increased caregiver burden. The potential role that family caregivers could play in delirium prevention and how nurses could facilitate family participation has been largely unexplored. The Calgary Family Intervention Model (CFIM), operating on the assumptions of a family-centered care philosophy, provided a framework for understanding the feasibility …

The Role Of Human And Social Capital In The Perpetuation Of Leader Development, Jeffrey W. Mott

Open Access Dissertations

This dissertation examined the critical role of human and social capital in the evolution of the NCAA Division I men's collegiate basketball product over time. Specifically, it sought to understand the characteristics of coaching networks that were consistently successful in perpetuating leader development over time, thereby theoretically replicating positive performance outcomes over long time spans. Interviews, content analyses and a literature search were performed to evaluate factors such as the processes of identification and selection of assistant coaches, the learning systems associated with their leader development, the strategies for their career advancement and growth, and the support structures of ongoing …

An Investigation Of Temporal Resolution Abilities In School-Aged Children With And Without Dyslexia, Elena Zaidan

Open Access Dissertations

Dyslexia is a clinical diagnosis often associated with phonological processing deficits. There are, however, other areas of concern, such as the presence of auditory temporal processing (ATP) disorders. One method of investigating ATP is the gap detection (GD) paradigm. This study investigated GD performance using the Gaps-in-Noise © (GIN) test in three groups of 30 children, aged 8 to 9 years. GD thresholds and gap identification scores (%) were determined for each participant. The three groups of participants included (Group I) children with dyslexia and phonological deficits, (Group II) children with dyslexia and no significant phonological deficits, and (Group III) …

Modifiable Risk Factors For Hypertensive Disorders Of Pregnancy Among Latina Women, Shannon Renee Turzanski Fortner

Open Access Dissertations

Hypertensive disorders of pregnancy affect approximately 8% of pregnancies, and can lead to serious complications for both mother and child. While Latinas are at two-fold increased risk of preeclampsia relative to non-Latina white women, little research on hypertension in pregnancy has been conducted in this population. Furthermore, there are few modifiable risk factors for hypertensive pregnancy. Therefore, we examined associations between psychosocial stress, physical activity, and pre-pregnancy BMI and gestational weight gain and hypertensive disorders of pregnancy using data from the Latina GDM Study, a prospective cohort study of 1,231 women. The first study evaluated the association between perceived stress …

Detrimental Effects Of Inactivity On Insulin Action, Brooke Rene Stephens

Open Access Dissertations

Inactivity reduces insulin action. Energy surplus causes similar reductions to insulin action. Unless energy intake is reduced to match low energy expenditure during inactivity, a concurrent energy surplus may account for the lower insulin action. This study evaluated the effect of inactivity (sitting) with and without energy surplus on insulin action. Fourteen young (26.1 ± 4.5 years (M ± SD)), lean (23.7 ± 7.1% fat), fit (VO 2peak = 49.1 ± 3.3 ml*kg -1 *min -1 ) men (n=7) and women (n=7) completed each of 3, 24-hour conditions: an active condition (i.e. high energy expenditure with energy intake matched to …

The Adoption Of Shamanic Healing Into The Biomedical Health Care System In The United States, Lori L. Thayer

Open Access Dissertations

Following cultural anthropological inquiry, this dissertation examines the adoption of shamanic healing techniques into Western medicine and the resultant hybrid modality of health care fostered by two disparate healing traditions. As the U.S. populace increasingly turns to alternative forms of healing in conjunction with, or in lieu of, conventional Western medicine, shamanic healing has been added to the list of recognized non-conventional therapies. Shamanism, once prevalent throughout most of the world in various cultural forms, is purported to be the oldest healing modality, dating back to the Upper Paleolithic in Siberia. Historical excoriation and extermination from religious and political dogma …

Role-Play Scenarios For Teaching Responsible Conduct Of Research: Assessment Of Outcomes, Stephanie N. Seiler, Michael C. Loui, Kerri L. Kristich, Kyoung Jin Kim, C. K. Gunsalus, Bradley J. Brummel

Ethics in Science and Engineering National Clearinghouse

No abstract provided.

Responsible Conduct Of Research Role-Plays: Conflict Of Interest, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This faculty adviser in this role-play has a major conflict of interest, which puts the student in an awkward situation. If the conflict oversight committee hasn’t contacted the student already (an unfortunately common situation), they should have. In an ideal situation, every student affected by a potential conflict of interest should have some written guidance about what to expect and how to get advice if concerns arise.

One useful step is to find out if there are any written policies or guidelines about what students can expect in situations like this: for example, is there a meeting annually or every …

Reduced Behavioral Response To Gonadal Hormones In Mice Shipped During The Peripubertal/Adolescent Period, Julie Laroche, Lauren Gasbarro, James P. Herman, Jeffrey D. Blaustein

Jeffrey D. Blaustein

Animals shipped from commercial suppliers to laboratories are exposed to a wide variety of stressors. Female C57Bl6/J mice shipped during the peripubertal/adolescent period (6 wk old) display lower levels of female sexual behavior in response to estradiol and progesterone injections after ovariectomy when tested in adulthood than female mice shipped in adulthood (12 wk old). These shipping-induced reductions in female sexual behavior appear to be limited to a vulnerable period around the time of puberty. Likewise, male mice shipped at 6 wk of age express lower levels of masculine sexual behavior in response to testosterone treatment as adults than do …

Federal Register: National Science Foundation, Responsible Conduct Of Research, National Science Foundation

Ethics in Science and Engineering National Clearinghouse

The National Science Foundation (NSF) is soliciting public comment on the agency’s proposed implementation of Section 7009 of the America Creating Opportunities to Meaningfully Promote Excellence in Technology, Education, and Science (COMPETES) Act (42 U.S.C. 1862o–1). This section of the Act requires that ‘‘each institution that applies for financial assistance from the Foundation for science and engineering research or education describe in its grant proposal a plan to provide appropriate training and oversight in the responsible and ethical conduct of research to undergraduate students, graduate students, and postdoctoral researchers participating in the proposed research project.’’

[Abstract by author]

Ethical Issues In Peer Review Of Research, Michael C. Loui

Ethics in Science and Engineering National Clearinghouse

No abstract provided.

Quantification Of Hormesis In Anticancer-Agent Dose-Responses, Marc A. Nascarella, Edward J. Stanek, George R. Hoffmann, Edward J. Calabrese

Edward J. Stanek

Quantitative features of dose responses were analyzed for 2,189 candidate anticancer agents in 13 strains of yeast (Saccharomyces cerevisiae). The agents represent a diverse class of chemical compounds including mustards, other alkylating agents, and antimetabolites, inter alia. Previous analyses have shown that the responses below the toxic threshold were stimulatory and poorly predicted by a threshold dose-response model, while better explained by a hormetic dose-response model. We determined the quantitative features of the hormetic concentration-responses (n = 4,548) using previously published entry and evaluative criteria. The quantitative features that are described are: (1) the width of the concentration range showing …

Physical Activity And Maternal/Fetal Outcomes In A Pregnant Latina Population, Audra L Gollenberg

Doctoral Dissertations 1896 - February 2014

Physical activity guidelines encouraging activity among healthy pregnant women have been issued by the Centers for Disease Control and Prevention, yet Latina women remain more sedentary than non-Latina white women. Latina women are also at higher risk for gestational diabetes mellitus and, among Latina women, Puerto Rican women have the highest rates of low birth weight and preterm-related infant death. This dissertation utilized data from the Latina GDM study, a prospective cohort study of 1,231 Latina women recruited early in pregnancy and followed through delivery. Participants were interviewed in early and mid pregnancy for assessment of sociodemographics, acculturation, medical, and …

Responsible Conduct Of Research Role-Plays: Whistleblowing Data Management, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This role-play involves data mismanagement in a research lab. The graduate students suspects that the post-doc fabricated experimental results, which is a form of research misconduct. The realization or suspicion that someone has engaged in research misconduct is one of the most difficult situations researchers face. However, someone who has witnessed misconduct has an obligation to act and report this behavior. Reporting the misconduct, which also known as whistle-blowing, should be done in a cautious and responsible way. Ideally, whistle-blowers should never be afraid to come forward with questions of misconduct, as they should be supported by their institutions and …

Responsible Conduct Of Research Role-Plays: Hazardous Substances, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This role-play focuses on the dilemmas in balancing regulatory requirements, personal relationships and a natural reluctance to “cause trouble.” These dilemmas arise in many settings, and can be particularly acute in laboratories that handle hazardous substances because of the serious safety implications of violations. In addition, violations can carry fines and penalties for laboratories and universities where they occur. The worries of the graduate student in the role-play about potential laboratory shut-downs and corresponding research delays are all too real. Specifics of regulations vary according to the materials being handled. The underlying principles regarding human and environmental safety stay the …

Responsible Conduct Of Research Role-Plays: Human Subjects, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This role-play addresses issues involved with human subject research and working with an Institutional Review Board (IRB).

The Belmont Report (1979) identifies three basic ethical principles that underlie all human subject research. These principles are Respect for persons, Beneficence, and Justice. Respect for persons requires us to treat individuals as autonomous human beings and not to use people as a means to an end. We must allow people to choose for themselves and provide extra protection to those with limited ability to choose, such as children. Rules derived from the principle of respect for persons include the requirements to obtain …

Responsible Conduct Of Research Role-Plays: Peer Review, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This scenario is based on “What is Responsible Peer Review?” http://ccnmtl.columbia.edu/projects/rcr/rcr_authorship/case/index.html#2, which is based on the “Confidentiality vs. Mentor Responsibilities: A Conflict of Obligations” scenario, http://onlineethics.org/reseth/appe/vol3/conflictobligations.html, which is based on a real incident.

This scenario highlights several issues in the peer review of manuscripts submitted for publication:

• Conflict of interest in the role of the reviewer

• Confidentiality of information in the manuscript

• Role of the adviser in the professional development of a graduate student

Although this scenario is not based on a single actual incident, each of the scenario’s elements occurs frequently in research in science and …

Responsible Conduct Of Research Role-Plays: Animals, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This scenario highlights ethical issues in reporting violations in a situation where extensive federal regulations and guidance apply. Specifically, the lab was using animals in ways that violated its own protocol and included making unauthorized purchases of animals.

The driving issue in this scenario is how to handle the discovery that another lab might have violated these regulations. Labs often have a great deal of autonomy and faculty members may feel uncomfortable questioning the conduct of their colleagues. Professor Prenlen appears to be violating animal care regulations, and involving students in those violations. This creates a difficult situation for the …

Responsible Conduct Of Research Role-Plays: Whistle-Blowing And Professional Relationships, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This role-play focuses on a whistle-blowing scenario involving data management issues in a research lab, complicated by uncomfortable personal relationships. Whistle-blowing involves raising concerns or allegations of wrongdoing or misconduct. There is an obligation for whistle-blowers to do so in good faith, which means based on reasonable belief or facts. Suspecting that someone has engaged in research misconduct is one of the most difficult situations researchers face. This is especially true when relationships are strained for other reasons.

If you have the suspicion of research misconduct, the possible consequences for all involved can be serious. To handle the situation responsibly …

Responsible Conduct Of Research Role-Plays: Authorship, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This role-play deals with issues concerning authorship credit. Concerns about authorship raise the ethical principle of fairness because people should receive credit for their contributions. Authors of a scientific work must have made substantial or significant contributions to the project because they are taking public responsibility for its content. Authors must also be willing and able to respond to questions about the work. The hard part of authorship is deciding what kind of intellectual contribution counts as substantial or significant and therefore warrants authorship. Despite the availability of guidelines, there are differences of opinions within and between scientific disciplines. Broad …

Responsible Conduct Of Research Role-Plays: Mentoring, C. K. Gunsalus, M. C. Loui, C. K. Gunsalus, M. C. Loui, And Their Students At The University Of Illinois At Urbana-Champaign

Ethics in Science and Engineering National Clearinghouse

This scenario highlights the mismatch of expectations that can arise in a mentoring relationship between a graduate student and a research adviser. The adviser wants a solely professional relationship, but the student seeks a more personal relationship. Their inconsistent desires lead to inconsistent expectations about how long they should meet and what they should discuss, and subsequently to misunderstandings about the preliminary results.

Some of the problems in this scenario could have been avoided had the adviser and student negotiated mutual expectations and responsibilities when they first began working together. In general, a professor and student should agree on expectations, …

Do Metabolic And Psychosocial Responses To Exercise Explain Ethnic/Racial Disparities In Insulin Resistance?, Rebecca E Hasson

Doctoral Dissertations 1896 - February 2014

Introduction . Non-Hispanic blacks (blacks) are more insulin resistant compared to non-Hispanic whites (whites), increasing their risk for Type 2 diabetes. The role played by ethnic/racial disparities in the response to physical activity in mediating those higher rates of insulin resistance in blacks is unknown. Because the beneficial effects of exercise are transient and require subsequent doses of exercise to maintain the effect; the metabolic and psychosocial responses to single exercise bouts have strong implications for both opposing insulin resistance and raising the probability that an individual will continue to exercise. Purpose . To compare the metabolic and psychosocial responses …

Approaches To Estimation Of Haplotype Frequencies And Haplotype-Trait Associations, Xiaohong Li

Doctoral Dissertations 1896 - February 2014

Characterizing the genetic contributors to complex disease traits will inevitably require consideration of haplotypic phase, the specific alignment of alleles on a single homologous chromosome. In population based studies, however, phase is generally unobservable as standard genotyping techniques provide investigators only with data on unphased genotypes. Several statistical methods have been described for estimating haplotype frequencies and their association with a trait in the context of phase ambiguity. These methods are limited, however, to diploid populations in which individuals have exactly two homologous chromosomes each and are thus not suitable for more general infectious disease settings. Specifically, in the context …