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Genetic Variability In Igf-1 And Igfbp-3 And Body Size In Early Life, Elizabeth Poole, Shelley Tworoger, Susan Hankinson, Heather Baer
Genetic Variability In Igf-1 And Igfbp-3 And Body Size In Early Life, Elizabeth Poole, Shelley Tworoger, Susan Hankinson, Heather Baer
Susan E. Hankinson
Background Early life body size and circulating levels of IGF-1 and IGFBP-3 have been linked to increased risks of breast and other cancers, but it is unclear whether these exposures act through a common mechanism. Previous studies have examined the role of IGF-1 and IGFBP-3 genetic variation in relation to adult height and body size, but few studies have examined associations with birthweight and childhood size. Methods We examined whether htSNPs in IGF-1 and the IGFBP-1/IGFBP-3 gene region are associated with the self-reported outcomes of birthweight, body fatness at ages 5 and 10, and body mass index (BMI) at age …