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Adiposity And The Development Of Premenstrual Syndrome, Elizabeth Bertone-Johnson, Susan Hankinson, Walter Willett, Susan Johnson, Joann Manson
Adiposity And The Development Of Premenstrual Syndrome, Elizabeth Bertone-Johnson, Susan Hankinson, Walter Willett, Susan Johnson, Joann Manson
Elizabeth R. Bertone-Johnson
Background Moderate to severe premenstrual syndrome (PMS) affects 8%–20% of premenopausal women and causes substantial levels of impairment, but few modifiable risk factors for PMS have been identified. Adiposity may impact risk through the complex interaction of hormonal and neurochemical factors, but it is not known if adiposity increases a woman's risk of developing PMS. We have addressed these issues in a prospective study nested within the Nurses' Health Study 2. Methods Participants were a subset of women aged 27–44 and free from PMS at baseline, including 1057 women who developed PMS over 10 years of follow-up and 1968 controls. …