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Full-Text Articles in Medicine and Health Sciences
Mechanisms Of Therapeutic Resistance In Castration Resistant Prostate Cancer, Sarah Katherine Martin
Mechanisms Of Therapeutic Resistance In Castration Resistant Prostate Cancer, Sarah Katherine Martin
Theses and Dissertations--Molecular and Cellular Biochemistry
Taxane based chemotherapy is an effective treatment for castration-resistant prostate cancer (CRPC) via stabilization of microtubules. Progression to castration-resistant prostate cancer is characterized by increased androgen receptor (AR), elevated intra-prostatic androgens and activated AR signaling despite castrate levels of androgens.
Previous studies identified that the inhibitory effect of microtubule targeting chemotherapy on AR activity was conferred by interfering with AR intracellular trafficking. The N-terminal domain (NTD) of AR was identified as a tubulin interacting domain that can be effectively targeted by the novel small molecular inhibitor, EPI. Taken together, this evidence provided the rationale that targeting AR nuclear translocation and …
The Psychological Well-Being Of Men Diagnosed With Prostate Cancer, Lee A. Walmsley
The Psychological Well-Being Of Men Diagnosed With Prostate Cancer, Lee A. Walmsley
Theses and Dissertations--Nursing
Prostate cancer (PC) affects one in eight men in North America and continues to be the most common site of cancer in males, especially among older men in Europe and the United States, and the second most common cancer worldwide. Prostate cancer is, after lung cancer, the most common cause of cancer-related deaths among men with an estimated 27,540 deaths in 2015.
The well-being of patients diagnosed with PC is a largely unexplored research area. Numerous factors likely impact men’s psychological well-being as they progress through the experience of managing PC. Among the various factors that may predict psychological well-being …