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Degenerative Suspensory Ligament Desmitis|Peruvian Paso|whole genome scan|connective tissue diseases|linkage disequilibrium
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The Use Of A Whole Genome Scan To Find A Genetic Marker For Degenerative Suspensory Ligament Desmitis In The Peruvian Paso Horse, Diane I. Strong
The Use Of A Whole Genome Scan To Find A Genetic Marker For Degenerative Suspensory Ligament Desmitis In The Peruvian Paso Horse, Diane I. Strong
University of Kentucky Master's Theses
Degenerative suspensory ligament desmitis (DSLD) is a debilitating disease of connective tissues seen in many breeds but has become prevalent in the Peruvian Pasohorse. DSLD is believed to be a genetic disorder caused by one primary founder and most likely has a recessive mode of inheritance although a dominant or co-dominant mode of inheritance has not been ruled out.
A genome scan using 259 microsatellite markers was used to test for linkage disequilibrium between one or more markers and DSLD. Two groups of Peruvian Pasohorses were selected from one population including the US and Canada. The only difference between the …