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A Novel Role For Neurotensin In Regulation Of Stem Cell Function In The Small Intestine, Stephanie Rock
A Novel Role For Neurotensin In Regulation Of Stem Cell Function In The Small Intestine, Stephanie Rock
Theses and Dissertations--Toxicology and Cancer Biology
Neurotensin (NT) is a nutrient-regulated gut hormone that plays important roles in lipid absorption, obesity, metabolic disorders, and normal and neoplastic growth in the intestine. In this study, we 1) elucidate the mechanisms regulating NT release from endocrine cells, 2) examine the role of NT on proliferation and stem cell function in the small intestine and 3) define the effects of NT on colorectal cancer stem cells. We report that NT release from endocrine cells is enhanced by the MAPK scaffold protein Kinase Suppressor of Ras 1 (KSR1) and the exocyst complex component 70 (Exo70). Moreover, free fatty acid stimulated …