Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Effects Of Cellular Heterogeneity And Immune Cells In Angiotensin Ii-Infused Hemorrhaged Ascending Aortas, Kyung Sik Jung
Effects Of Cellular Heterogeneity And Immune Cells In Angiotensin Ii-Infused Hemorrhaged Ascending Aortas, Kyung Sik Jung
Theses and Dissertations--Toxicology and Cancer Biology
A previous thoracic aortic aneurysm time course study from our laboratory determined that ascending aortic dilation was significantly increased by day 5, and reached a plateau by day 28 of angiotensin II (AngII) infusion. We also found that mice had hemorrhage localized to the ascending aortas by day 5 of AngII infusion. The purpose of these studies was to provide mechanistic insight into the development of AngII-induced ascending aortic hemorrhage.
Male C57BL/6 mice fed normal diet were subcutaneously infused with either AngII (1000 ng/kg/min) or saline for 5 days. To examine cellular heterogeneity, hemorrhaged ascending aortas were collected and sectioned …